Navigation Links
New technology provides first view of DNA damage within entire human genome

New technology providing the first view of DNA damage throughout the entire human genome developed by Cardiff University scientists could offer a valuable new insight into the development and treatment of conditions like cancer.

Professor Ray Waters, Dr Simon Reed and Dr Yumin Teng from Cardiff University's Department of Genetics, Haematology and Pathology have developed a unique way of measuring DNA damage frequency using tiny microarrays.

Using the new method Cardiff scientists can, for the first time, examine all 28,000 human genes where previous techniques have only allowed scientists to analyse parts of about five human genes.

The new patented technique offers an unprecedented view of DNA damage in humans caused by agents that can create conditions like cancer.

Professor Waters said: "This is really an exciting development and offers us the chance to examine DNA damage in the entire human genome.

"The approach is especially useful to examine the damage to people's DNA that can go on to cause cancer. We can also examine DNA damaging anti-cancer therapeutics and how responses in individual patients vary."

Human DNA can be damaged in many different ways through radiation, chemicals and events in the body itself. Genetic defects in DNA repair can lead to cancer prone conditions, immunity defects, premature ageing and other problems.

In normal individuals there are many examples of DNA damage being linked to cancer, for example through smoking or over exposure to ultra-violet rays.

There is little evidence as to how DNA repair varies amongst the normal population and how normal individuals cope with anti-cancer therapies that damage the DNA in their cancer cells and normal cells.

The novel technology, developed with funding from the Medical Research Council (MRC) and Cancer Research Wales, will have implications for cancer risk assessment, for cancer diagnostics and for developing new cancer therapeutics.

Professor Ray Waters is Head of Cardiff University's Cancer Studies Interdisciplinary Research Group. Consisting of more than 50 researchers, the Group is working together on new cancer therapeutics and diagnostics which can be taken through to the clinic.

He was deputy chair of the UK Government Committee on Medical Aspects of Radiation in the Environment (COMARE) and he drove its 2009 report on the health risks associated with sunbed usage.

Professor Waters added: "The method has some very exciting potential applications. We are already working alongside companies such as Agilent to see if our method can be used by the chemical and pharmaceutical industries for routine genotoxicity testing. Here, determining whether new agents damage DNA is a crucial step in their development

"The technique could also be used for other purposes like examining DNA damage in the skin from sunburn, and we will be looking to develop this application over the coming months and years.

"For future developments input from our current team of Mark Bennett, Yanbo Deng, Katie Evans, Matthew Leadbitter, Dr James Powell and Dr Shirong Yu will be crucial."


Contact: Ray Waters
Cardiff University

Related biology news :

1. BIO-key(R) to Showcase Biometric Security Applications at 2008 Biometric Technology Expo
2. Stantum Offering Demo, Evaluation & Development Board Based on Its Patented Resistive Multi-Touch Technology
3. Neurotechnology Releases SentiSight 2.0 SDK Universal Object Recognition Technology
4. Audience Selected as Silver Winner in This Years Wall Street Journal Technology Innovation Awards and Winner of the Semiconductors Category
5. Breakthrough optical technology to assess colon cancer risk, accuracy
6. So-called sandfish could help materials handling and process technology specialists
7. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
8. Human Microbiome Project awards funds for technology development, data analysis and ethical research
9. Europe rallies behind nanotechnology to wean world from fossil fuels
10. Nanotechnology boosts war on superbugs
11. Cost-effective farm waste-to-energy technology focus of research
Post Your Comments:
(Date:10/29/2015)... , Oct. 29, 2015   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... Tech Association (MHTA) as one of only three finalists ... "Software – Small and Growing" category. The Tekne Awards honor ... have shown superior technology innovation and leadership. ...
(Date:10/29/2015)... Daon, a global leader in mobile biometric ... new version of its IdentityX Platform , IdentityX ... have already installed IdentityX v4.0 and are ... FIDO UAF certified server component as an option ... features. These customers include some of the largest and ...
(Date:10/29/2015)... , Oct. 29, 2015  Connected health pioneer, ... the explosion of technology-enabled health and wellness, and the ... book, The Internet of Healthy Things ... or smartphones even existed, Dr. Kvedar, vice president, Connected ... health care delivery, moving care from the hospital or ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... InSphero AG, the leading supplier of easy-to-use solutions ... Melanie Aregger to serve as Chief Operating Officer. , Having joined InSphero ... team and was promoted to Head of InSphero Diagnostics in 2014. There ...
(Date:11/24/2015)... QC , Nov. 24, 2015 /CNW Telbec/ - ProMetic ... "Corporation") announced today that Mr. Pierre Laurin , President ... corporate presentation at the upcoming Piper Jaffray 27 th ... Palace Hotel, on December 1-2, 2015. st ... available for one-on-one meetings throughout the day. The presentation will ...
(Date:11/24/2015)... Nov. 24, 2015 HemoShear Therapeutics, LLC, ... drugs for metabolic disorders, announced today the appointment ... Board of Directors (BOD). Mr. Watkins is the ... Genome Sciences (HGS), and also served as the ... Jim Powers , Chairman and CEO of HemoShear ...
(Date:11/24/2015)... NEW YORK , November 24, 2015 /PRNewswire/ ... Bristol-Myers Squibb in a European ... Company in which the companies will work closely together ... other areas of unmet medical need. The collaboration is underpinned ... the latest LSP fund. This is the first investment by ...
Breaking Biology Technology: