Navigation Links
New technology provides first view of DNA damage within entire human genome
Date:1/18/2011

New technology providing the first view of DNA damage throughout the entire human genome developed by Cardiff University scientists could offer a valuable new insight into the development and treatment of conditions like cancer.

Professor Ray Waters, Dr Simon Reed and Dr Yumin Teng from Cardiff University's Department of Genetics, Haematology and Pathology have developed a unique way of measuring DNA damage frequency using tiny microarrays.

Using the new method Cardiff scientists can, for the first time, examine all 28,000 human genes where previous techniques have only allowed scientists to analyse parts of about five human genes.

The new patented technique offers an unprecedented view of DNA damage in humans caused by agents that can create conditions like cancer.

Professor Waters said: "This is really an exciting development and offers us the chance to examine DNA damage in the entire human genome.

"The approach is especially useful to examine the damage to people's DNA that can go on to cause cancer. We can also examine DNA damaging anti-cancer therapeutics and how responses in individual patients vary."

Human DNA can be damaged in many different ways through radiation, chemicals and events in the body itself. Genetic defects in DNA repair can lead to cancer prone conditions, immunity defects, premature ageing and other problems.

In normal individuals there are many examples of DNA damage being linked to cancer, for example through smoking or over exposure to ultra-violet rays.

There is little evidence as to how DNA repair varies amongst the normal population and how normal individuals cope with anti-cancer therapies that damage the DNA in their cancer cells and normal cells.

The novel technology, developed with funding from the Medical Research Council (MRC) and Cancer Research Wales, will have implications for cancer risk assessment, for cancer diagnostics and for developing new cancer therapeutics.

Professor Ray Waters is Head of Cardiff University's Cancer Studies Interdisciplinary Research Group. Consisting of more than 50 researchers, the Group is working together on new cancer therapeutics and diagnostics which can be taken through to the clinic.

He was deputy chair of the UK Government Committee on Medical Aspects of Radiation in the Environment (COMARE) and he drove its 2009 report on the health risks associated with sunbed usage.

Professor Waters added: "The method has some very exciting potential applications. We are already working alongside companies such as Agilent to see if our method can be used by the chemical and pharmaceutical industries for routine genotoxicity testing. Here, determining whether new agents damage DNA is a crucial step in their development

"The technique could also be used for other purposes like examining DNA damage in the skin from sunburn, and we will be looking to develop this application over the coming months and years.

"For future developments input from our current team of Mark Bennett, Yanbo Deng, Katie Evans, Matthew Leadbitter, Dr James Powell and Dr Shirong Yu will be crucial."


'/>"/>

Contact: Ray Waters
watersr1@cardiff.ac.uk
44-292-068-7336
Cardiff University
Source:Eurekalert

Related biology news :

1. BIO-key(R) to Showcase Biometric Security Applications at 2008 Biometric Technology Expo
2. Stantum Offering Demo, Evaluation & Development Board Based on Its Patented Resistive Multi-Touch Technology
3. Neurotechnology Releases SentiSight 2.0 SDK Universal Object Recognition Technology
4. Audience Selected as Silver Winner in This Years Wall Street Journal Technology Innovation Awards and Winner of the Semiconductors Category
5. Breakthrough optical technology to assess colon cancer risk, accuracy
6. So-called sandfish could help materials handling and process technology specialists
7. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
8. Human Microbiome Project awards funds for technology development, data analysis and ethical research
9. Europe rallies behind nanotechnology to wean world from fossil fuels
10. Nanotechnology boosts war on superbugs
11. Cost-effective farm waste-to-energy technology focus of research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... , Jan. 20, 2016   MedNet Solutions ... the entire spectrum of clinical research, is pleased to ... MedNet,s significant achievements are the result of the company,s ... iMedNet eClinical , it,s comprehensive, easy-to-use and ... --> Key MedNet growth achievements in ...
(Date:1/13/2016)... 13, 2016 --> ... new market report titled - Biometric Sensors Market - Global ... - 2023. According to the report, the global biometric sensors market was ... to reach US$1,625.8 mn by 2023, expanding at a ... of volume, the biometric sensors market is expected to ...
(Date:1/8/2016)... MANCHESTER, United Kingdom , Jan. 8, 2016   ... diagnostic products, today announced the closing of a $9 million ... Proceeds from the financing will be used to accelerate the ... for detecting early-stage pressure ulcers. United ... receiving CE Mark approval. The device,s introduction has been met ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... , ... February 11, 2016 , ... ... more than 150 years, continues today to pursue the highest level of accuracy ... analytical instruments: the AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and ...
(Date:2/10/2016)... WASHINGTON , February 10, 2016 Early-career ... , Peru , Uganda ... their life-enhancing work in health and nutrition   Indonesia ... Uganda and Yemen are ... sciences and epidemiology. They are also celebrated for mentoring young women scientists ...
(Date:2/10/2016)... York, New York (PRWEB) , ... ... ... Pharmaceuticals Inc. (NASDAQ: REGN) today announced that it has joined the Human ... and immunotherapies for infectious diseases and cancer. , The Human Vaccines ...
(Date:2/10/2016)... ... February 10, 2016 , ... Benchmark Research, a ... promotion of two long-standing principal investigators (PI) to the roles of Chief Medical ... Development. , Dr. Laurence Chu, a Benchmark Research PI in the Austin office, ...
Breaking Biology Technology: