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New technology pinpoints genetic differences between cancer and non-cancer patients
Date:2/22/2011

he clinic. What just came out in our paper is a description of the technology that allows us to very quickly and efficiently and inexpensively measure these two million places using a uniquely designed microarray It's the pattern on that microarray that provides us the information we need."

Watch a video of Garner discussing the research and its implications (http://www.youtube.com/watch?v=I0BOq5b5HnM).

Only a small percentage of microsatellites have been linked to cancer and other diseases because there hasn't been an effective method available for evaluating large numbers of these sequences. This technology is enabling scientists to understand the role of these understudied parts of our genome for the first time and may help explain the difference between the known genetic components in disease and those that have been explained by genomic studies. This tool can be used to identify and better understand genetic changes in many different types of cancer with the potential to serve as a universal cancer biomarker. It has already been instrumental in the discovery of a new biomarker (http://bit.ly/gPcJkC) in the estrogen-related receptor gamma (ERR-γ) gene, which indicates an individual's increased risk for breast cancer. The group is now pursuing a number of these cancer predisposition risk markers in colon, lung, and other cancers.


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Contact: Susan Bland
subland@vbi.vt.edu
540-231-7912
Virginia Tech
Source:Eurekalert

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