Navigation Links
New technology offers insight into cholesterol
Date:8/14/2014

Researchers from the Copenhagen Center for Glycomics at the University of Copenhagen have studied an important receptor protein called LDLR using new, groundbreaking techniques. The protein plays an important role in the absorption of the bad cholesterol, LDL.

The findings have just been published in the Journal of Biological Chemistry.

The key to major discoveries within the fields of health and diseases is not just hidden in the human DNA code. The proteins encoded by the genes also play an important role, not least the attached sugar chains which give the proteins an identity and handle important functions in the human organism. Researchers have now studied how LDLR is decorated with sugar molecules, so-called glycosylation modifications.

- We have not previously had a simple method for studying where glycosylation modifications are located on proteins in the body, because the sugars are very complicated and appear in different combinations. By removing the Cosmc protein, which is necessary for extending the sugar modifications, we have created cells with simplified glycosylations, which we call SimpleCells. The technique has enabled us to see 20 times as many sugar modifications on our proteins as were previously known, says PhD Nis Borbye Pedersen, formerly postdoc at the Copenhagen Center for Glycomics, now postdoc at the Department of Biology, University of Copenhagen.

A surprising finding

An interesting finding of the study, characterised as a regular breakthrough by Nis Borbye Pedersen, is the discovery of which of the 20 almost identical enzymes is responsible for the so-called O-glycosylation, where the GalNAc sugar molecule is bound to the amino acids serine and threonine.

- So far, we have not really understood why the body has produced 20 more or less identical enzymes. We have now found out that only one of them seems to be involved in precisely these sugar modifications: GalNAc-T11. So the study provides us with an understanding of which tasks the 20 enzymes perform, he says.

Sugar the key to cholesterol

The researchers from the Copenhagen Center for Glycomics are now conducting new studies which indicate that the presence or not of sugar modifications on the receptor protein LDLR does have a functional impact. The new results may play a role in the future treatment of cholesterol.

- We are currently studying whether glycosylation affects the receptor protein's ability to bind and remove cholesterol from the blood. It has long been known that the receptor protein LDLR plays a key role, at the molecular level, to getting rid of the bad cholesterol and thus improving our health, and so understanding the regulation of this important receptor protein is very valuable. At best, it may improve the strategy for treating high blood cholesterol levels, says Nis Borbye Pedersen.


'/>"/>

Contact: Nis Borbye Pedersen
nis.pedersen@bio.ku.dk
45-35-33-04-51
University of Copenhagen The Faculty of Health and Medical Sciences
Source:Eurekalert

Related biology news :

1. Introducing SentiBotics Mobile Robotics Development Kit from Neurotechnology
2. Fruit flies going high-tech: How touchscreen technology helps to understand eating habits
3. Smart Technology Consumers Interest in Mobile Payment Products Grows - Company Secures Deal with Major Airline to Display Advertisements in Flight for its Next Generation Smart Wallet
4. Wyss Institutes technology translation engine launches Organs-on-Chips company
5. Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency
6. Global Next Generation Biometric Market by Technology, Function, Application & by Geography - Forecasts & Analysis to 2020
7. Rutgers chemists develop technology to produce clean-burning hydrogen fuel
8. International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019
9. New technology reveals insights into mechanisms underlying amyloid diseases
10. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
11. Nanotechnology for a sustainable future, new book offers insights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , Apr. 11, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global eye tracking market to grow at a CAGR ... Global Eye Tracking Market 2017-2021, has been prepared based on an ... the market landscape and its growth prospects over the coming years. ...
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... Palo Alto, CA (PRWEB) , ... September 20, ... ... and public interest organization focused on molecular manufacturing and other transformative technologies, announced ... categories, one for Experiment and the other for Theory in nanotechnology/molecular manufacturing. , ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... automates the most dangerous step of sample prep for metals digestion—the addition of ... automation at an affordable price. The system is ideal for any laboratory performing ...
(Date:9/19/2017)... ... September 19, 2017 , ... A best-selling author and an ... “Grit” author Angela Duckworth and her team at Character Lab have joined Philadelphia’s ... international law firm with decades of experience supporting high-growth companies in the technology ...
(Date:9/19/2017)... ... 19, 2017 , ... The new and improved Oakton® pocket testers, from Cole-Parmer, ... upright with a new cap design that is versatile, functional and leakproof. They are ... to test water quality. , The Oakton pocket testers have many user-friendly and functional ...
Breaking Biology Technology: