Navigation Links
New technology may prolong the life of implanted devices, from pacemakers to chemotherapy ports
Date:8/23/2010

LOUISVILLE, Ky. -- By creating a unique system of blood vessels that is engineered to interact with the tissue surrounding an implanted device, the longevity and function of these devices may be better preserved, according to a study led by researchers in the University of Louisville/ Jewish Hospital's Cardiovascular Innovation Institute (CII).

The study was published early online on August 23, 2010 in the Journal of Biomedical Materials Research and was funded by the National Institutes of Health.

"One of the biggest problems with any kind of implanted device, such as pacemaker, a chemotherapy port or the glucose sensors necessary to monitor blood sugar levels in diabetic patients, is the body's natural reaction to recognize it as foreign and form a scar around it," said Stuart Williams, PhD, scientific director of the CII and a senior investigator on the study. "Scars have very little blood flow and because this connection between the body and the device is compromised, the function of the device over time can decline, threatening health and leading to additional interventions to replace it."

The researchers sought to prevent the formation of scar tissue around an implanted device by "pre-vascularizing" the device just prior to implantation. The investigators call this a microvascular construct (MVC) consisting of tiny blood vessel fragments suspended in a collagen gel. The combination of the MVC, already rich with blood vessels, and the device appears to provide an environment that resists the formation of scar tissue once the device is implanted, Williams said.

"This study built on our earlier work that showed that this material, what we call an MVC, stimulates circulation and prevents scarring when implanted in the body, in animal models," said James Hoying, PhD, director of cardiovascular therapeutics at the CII and a senior investigator on this study. "We wanted to next see if we could maintain that circulation in order to prevent scarring over the long term and thus prolong the function of any number of implanted devices."

The researchers compared the tissue surrounding a bare expanded polytetrafluoroethylene material implanted biomaterial many devices are made of embedded in collagen alone to one embedded in collagen and the MVC, and found that the latter both promoted and maintained circulation in the area around the implant, Williams said. Animal models were used. Collagen is a naturally occurring protein found in the flesh and connective tissue of animals and humans. It has been found to mediate the inflammatory reaction that often occurs when an implanted device interacts with surrounding tissue.

"We found that the presence of the MVCs and collagen altered the way tissue formed around the implants, restricting the formation of scar tissue because there was so much blood vessel activity," Williams said. "The presence of the MVCs and collagen also reduced the number of white blood cells that stimulate inflammation, where the device was implanted. The vessels associated with the implant were seen to be capable of sustainable blood delivery over time."

All of these factors are important in sustaining circulation and suppressing scar formation, he said.

Williams and colleagues are now working to design an operating room-compatible device that could bring this technology to patients.

"This could have implications for patients who have any number of implantable devices, from those on dialysis to patients with devices that help failing hearts to function, to those receiving chemotherapy, catheters and multiple other indications," Williams said.


'/>"/>

Contact: Lauren Williams
lauren.williams@louisville.edu
502-852-7461
University of Louisville
Source:Eurekalert

Related biology news :

1. BIO-key(R) to Showcase Biometric Security Applications at 2008 Biometric Technology Expo
2. Stantum Offering Demo, Evaluation & Development Board Based on Its Patented Resistive Multi-Touch Technology
3. Neurotechnology Releases SentiSight 2.0 SDK Universal Object Recognition Technology
4. Audience Selected as Silver Winner in This Years Wall Street Journal Technology Innovation Awards and Winner of the Semiconductors Category
5. Breakthrough optical technology to assess colon cancer risk, accuracy
6. So-called sandfish could help materials handling and process technology specialists
7. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
8. Human Microbiome Project awards funds for technology development, data analysis and ethical research
9. Europe rallies behind nanotechnology to wean world from fossil fuels
10. Nanotechnology boosts war on superbugs
11. Cost-effective farm waste-to-energy technology focus of research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... News solutions for biometrics, bag drop and New ADA-compliant ... At PTE ... March, Materna will present its complete end-to-end passenger journey, ... real benefit for passengers. To accelerate the whole passenger handling ... solutions to take passengers through the complete integrated process with ...
(Date:2/22/2017)... 22, 2017 With the biometrics market ... identifies four technologies that innovative and agile startups ... share in the changing competitive landscape: multifactor authentication ...   "Companies can no longer afford ... says Dimitrios Pavlakis , Industry Analyst at ...
(Date:2/13/2017)... , Feb. 13, 2017  RSA Conference -- ... platform that is designed to enhance fraud detection ... release in the RSA Fraud & Risk Intelligence ... organizations to leverage additional insights from internal and ... to better protect their customers from targeted cybercrime ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... 2017 MiMedx Group, Inc. (NASDAQ: MDXG), the ... tissue allografts and patent-protected processes to develop and market ... announced today  that it will present at the Needham ... NY.  Parker H. "Pete" Petit, Chairman and CEO, ... M. Cashman , EVP and Chief Commercialization Officer, and ...
(Date:3/24/2017)... , March 24, 2017   Sienna Biopharmaceuticals, Inc. ... company, today announced that Richard Peterson will ... 24.   Peterson, who brings more than two ... Smither , who is retiring at the end of ... advisory capacity. Peterson joins Sienna from Novan, Inc., where ...
(Date:3/23/2017)... 2017  Northwest Biotherapeutics (OTCQB: NWBO) (NW Bio), ... for solid tumor cancers, today announced that yesterday ... announced last Friday, March 17, 2017. ... securities totaling 28,843,692 shares, comprised of 18,843,692 common ... of Class C Warrants pre-funded at the closing ...
(Date:3/23/2017)... 2017 Kineta, Inc., a biotechnology company ... in immuno-oncology, today announced the discovery and characterization ... that activate interferon response factor 3 (IRF3) via ... tumor regression in a murine colon carcinoma mouse ... complete tumor regression to initial drug treatment were ...
Breaking Biology Technology: