Navigation Links
New technology for boosting vaccine efficiency
Date:4/24/2008

One of the most pressing biomedical issues is the development of techniques that increase the efficiency of vaccines. In a paper published on April 24, 2008 in the journal Vaccine, a Massachusettss biotechnology company, Cure Lab, Inc. has proposed a new technology for anti-viral vaccination. This technology consists of two major elements. First, each vaccine antigen should be made in two forms. One is easily processed within the organisms cells by an intracellular chopping machine called the proteosome, while another is resistant to the chopping. Thus both these forms of an antigen would be used in combination to elicit a much stronger immune response than either of them would be able to do alone.

Imagine a vaccine that could make a cell within our body produce a viral protein. This is called a recombinant vaccine. Recombinant vaccines give the most hope today as anti-viral and anti-cancer vaccines. They train the immune system to recognize and eliminate first infected or cancerous cells, preventing a disease progression. In order for a recombinant vaccine to be effective, the produced viral protein must be presented by the cell to our immune system. This antigen presentation process is very complex and remains poorly understood.

A few years ago the situation seemed to be simple- said Dr. Alex Shneider, Founder and CEO of Cure Lab, Inc. - Vaccinologists believed that a recombinant vaccine makes the cell able to produce a viral protein. The proteosome cuts this protein into pieces. These pieces are then presented on the cell surface and stimulate immunity. If this was the complete story, life-saving solutions would be so close. A lot of research groups rushed to enhance their vaccines by fusing different viral proteins used in vaccines with specific transport signals directing the proteins to the proteosome. The logic was pretty straightforward. The more protein that would be targeted to a proteosome, the more protein segments generated for
'/>"/>

Contact: Alex Shneider
thoidis@curelab.com
609-841-1201
Cure Lab, Inc.
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related biology news :

1. Yale scientists use nanotechnology to fight E. coli
2. Voice Biometrics Gains Traction as Most Accurate and Convenient Technology to Secure Customer Privacy
3. M2SYS Partners with SecuGen Corporation to Support Market Leading Hamster Plus Fingerprint Reader with Auto-On Technology
4. Silicon Valley Technology Leaders LaserCard Corporation and Tesla Motors Sign LaserPass Secure Access Deal
5. Nanotechnology: Whats that?
6. UCs NIH grant brings technology from outer space to playgrounds
7. BIO-key(R) International to Showcase Deployed Biometric Security Applications at 2007 Biometric Technology Expo
8. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
9. UCLA/VA partners with ASU to advance biosensor technology for urinary tract infections
10. Herr receives Heinz Award for Technology, the Economy and Employment
11. Singapore National Science and Technology Awards

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/1/2009)...09: OptiNose is pleased to announce the publicatio...stigating the efficacy and tolerability of its nov... treatment of chronic rhinosinusitis with nasal po...nternational and European Rhinologic Societies. ,...hronic disease that can significantly reduce a pat...
(Date:12/1/2009)... Ohio State University cancer researchers have de...rain-tumor cells and blocks the growth of new tumo...uses designed to kill cancer cells oncolytic viru...ain tumors if they also carry a gene for a protein..., called vasculostatin, is normally produced in th...
(Date:12/1/2009)...la. Hit-and-run attacks by sharks can be solved w...y the unique chomp they put on their victims, acco...ark expert. , In a method analogous to analyzing...ations by precisely comparing shark bites to the j...ge Burgess, director of the International Shark At...
Breaking Biology News(10 mins):New data on highly effective treatment for chronic rhinosinusitis with nasal polyps 2Tumor-attacking virus strikes with 'one-two punch' 2New forensic technique gives clues about sharks from bite damage 2New forensic technique gives clues about sharks from bite damage 3Supply Chain Council Announces New Board of Directors and Officers 9218 1UK Identity and Passport Service and IBM Sign 7 year National Biometric Identity Service 28NBIS 29 Contract 9215 1UK Identity and Passport Service and IBM Sign 7 year National Biometric Identity Service 28NBIS 29 Contract 9215 2How to De Stress a Recession Riddled Life 51398 1How to De Stress a Recession Riddled Life 51398 2How to De Stress a Recession Riddled Life 51398 3
...mission, in which they are living and working at 6...e species of coral colonies survive transplanting ...colonies die. Coral reefs worldwide are suffering...arming, and increased boat traffic and pollution. ...ity among those who are concerned. Using as a hom...
... depleted. Traditional energy sources, like oil, h...The future, it seems, may depend on renewable ener...ines and commercial opportunities. , Tel Aviv Uni...newable energy a daily reality. , At Israel,s int...th, Tel Aviv University announced it will create a...
...further break-up with an area of about 160 km brea... satellite captured the event the first ever-docu...Shelf, a broad plate of floating ice south of Sout... to two islands, Charcot and Latady. In February 2...e shelf, narrowing the connection down to a 6 km s...
Other Biology News:8-day undersea mission begins experiment to improve coral reef restoration 2TAU announces new 'supercenter' for renewable energy 2TAU announces new 'supercenter' for renewable energy 3Even the Antarctic winter cannot protect Wilkins Ice Shelf 2
(Date:12/2/2009)... CALGARY, Dec. 2 /PRNewswire-FirstCall/ - Oncolyti...SX:ONC; NASDAQ: ONCY ) announced today that in con...g, the underwriters have exercised in full their o...37,500 units. Each unit is comprised of one common... and was sold at a price of US$3.00 per unit. Each...
(Date:12/2/2009)...SINGAPORE, Dec. 2 S*BIO Pte Ltd to... JAK2 inhibitor, SB1518, at The American Society o... New Orleans. ,, Data will be presented on the ...trial of SB1518 detailing its safety, tolerability...le in dose levels ranging from 100 to 600 mg. Thes...
(Date:12/2/2009)... The Scientist, a leading scientific magazi...’ Evolve “Intelligent” EMCCD cam...p 10 Innovations of 2009. , ... EMCCD camera from Photometrics ®, a designe...CD cameras for the life sciences, was ranked fourt...
(Date:12/1/2009)...NEW YORK, Dec. 1 Reportlinker.com ...ilable in its catalogue: ,, Industrial Enzymes...tlinker.com/p0164431/Industrial-Enzymes---A-Global...et is an oligopoly with few strong players and a h...ivities. Keen competition and commoditization char...
Breaking Biology Technology:Oncolytics Biotech(R) Inc. Announces Exercise of Underwriters' Over-Allotment Option 2Oncolytics Biotech(R) Inc. Announces Exercise of Underwriters' Over-Allotment Option 3Oncolytics Biotech(R) Inc. Announces Exercise of Underwriters' Over-Allotment Option 4S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders 2S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders 3S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders 4S*BIO Novel Oral JAK2 Inhibitor SB1518 Demonstrates Safety and Tolerability in Phase 1 Studies for the Treatment of Myeloproliferative and Other Hematological Disorders 5The Scientist Names Photometrics' Evolve EMCCD Camera One of the “Top 10 Innovations” of 2009 2The Scientist Names Photometrics' Evolve EMCCD Camera One of the “Top 10 Innovations” of 2009 3Reportlinker Adds Industrial Enzymes - A Global Market Report 2Reportlinker Adds Industrial Enzymes - A Global Market Report 3Reportlinker Adds Industrial Enzymes - A Global Market Report 4Reportlinker Adds Industrial Enzymes - A Global Market Report 5Reportlinker Adds Industrial Enzymes - A Global Market Report 6Reportlinker Adds Industrial Enzymes - A Global Market Report 7Reportlinker Adds Industrial Enzymes - A Global Market Report 8Reportlinker Adds Industrial Enzymes - A Global Market Report 9Reportlinker Adds Industrial Enzymes - A Global Market Report 10
.... - According to a recent article in Wisconsin T...e all policy that will not only improve Wisconsin,... economic recovery. After all, this strategy of mu...ed Denver from becoming yet another desolate, slee... and all of Colorado reduced to rubble following t...
...Blindness or low vision affects 3.3 million Americ... is projected to reach 5.5 million by the year 202...chives of Ophthalmology . , ,Because of an aging p...y vulnerable to common eye diseases responsible fo...on, glaucoma, cataract, and diabetic retinopathy. ...
...A research consortia comprised of top domestic aut...ery technology for hybrid-electric vehicles (HEVs)...mperatures, and it is counting on a prominent Milw...he U.S. Advanced Battery Consortium , a developer...erating under the FreedomCAR and Fuel Partnership...
Other Biology Technology:Denver prospered because of "dreaded" TABOR 2Denver prospered because of "dreaded" TABOR 3Medical College given funds for eye research 2Johnson Controls partnership wins new contract 2Johnson Controls partnership wins new contract 3
...oltage Clamp, as a Current Clamp or as a Conductan...pplications. Performance in any one mode is as goo...s amazing instrument is made possible by very rece...Processing (DSP) integrated circuit chips. Until v...
... a shutter (controlled via a TTL signal or switch ...gen Light Source combines the continuous spectrum ... a single optical path. The combined-spectrum ligh...15-200 nm. In addition, deep-UV versions of the li...
... expressed in g per ml and is determined from seri... of a 1 mg per ml solution. This activity is the...on of human blood group A erythrocytes after 1 hou... purified by a modification of the method of Hamme...
Agilent MSD Security ChemStation for GC and GC/MS from Agilent Technologies
Biology Products: