Navigation Links
New technology detect cellular memory
Date:2/24/2014

Cells in our body are constantly dividing to maintain our body functions. At each division, our DNA code and a whole machinery of supporting components has to be faithfully duplicated to maintain the cell's memory of its own identity. Researchers at BRIC, University of Copenhagen, have developed a new technology that has revealed the dynamic events of this duplication process and the secrets of cellular memory. The results are published in Nature Cell Biology.

In 2009, two women at BRIC, University of Copenhagen joined forces to develop a new technology that could elucidate the mystery behind cellular memory. Today, they are celebrating their first big discovery using this technology.

"Our technology can isolate the small molecular building blocks that bind to our DNA strand and organize it into a stringent architecture. Importantly, our technology can follow the dynamic duplication processes in our cells and can therefore reveal the life cycle of these DNA-complexes", says postdoc Constance Alabert who has been leading the laboratory work.

The molecular building blocks that our DNA is wrapped around are called histones and together, the DNA strand and the histones form a stringent structure called chromatin. When our cells divide during development and throughout life to maintain our body functions, the DNA code has to be faithfully duplicated and so do the chromatin and its architecture. Chromatin contains crucial information that tells our genes when to be active and when to be silent. For example, information stored in the chromatin silence liver specific genes in heart cells and vice versa. Therefore, the entire chromatin structure has to be duplicated at each cell division to maintain a cell's memory of its own identity.

It is no longer debated that the chromatin structure is crucial to maintain cell identity, but the how remains. As only hypothesis driven approaches has been available to study the dynamic event of chromatin duplication, only few molecular factors have been linked to the process.

"With our new technology, we have identified 100 new molecular components that appear to be involved in the tightly regulated process of chromatin duplication and thereby maintenance of cell memory. Thus, we provide a robust technology and the first comprehensive resource to address fundamental questions regarding maintenance of cell identity", says associate professor Anja Groth, who is heading the laboratory.

Understanding the fundamental principles of how chromatin is faithfully duplicated is essential to understand how our organism is developed and maintained, and also how diseases such as cancer arise. If cells lose their chromatin memory, they can potentially develop into cancer cells and form tumours. Such a loss of what is also called 'epigenetic' memory is now known to be involved in almost all cancer types. The next step for the researchers will be to decipher the mode of action of the 100 new chromatin factors.


'/>"/>

Contact: Katrine Sonne-Hansen
katrine.sonne@bric.ku.dk
45-35-32-56-48
University of Copenhagen
Source:Eurekalert  

Related biology news :

1. US lead in science and technology shrinking
2. Engineer brings new twist to sodium-ion battery technology
3. Symposia highlight smarter plant breeding for food and fuel, and nanotechnology for renewable energy
4. Vapor Corp. Unveils E-Cigarette Industrys First Biometric Technology
5. SensoMotoric Instruments Unveils SMI RED-n Consumer Eye Control Technology for Gaming and Computing
6. Imaging technology to improve survival of ischemic disease patients
7. Imaging technology could unlock mysteries of a childhood disease
8. Survey reveals regulatory agencies viewed as unprepared for nanotechnology
9. New energy harvesting technology set to reduce number of open-heart surgeries
10. Markets Poised for Healthy 2014 as Biometrics Makes Strides in Technology Sector - Company Strengthens Board with Industrys Top Leaders
11. Unique industry-academia networks in industrial biotechnology and bioenergy launched
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New technology detect cellular memory
(Date:11/15/2016)... 2016  Synthetic Biologics, Inc. (NYSE MKT: SYN), ... the gut microbiome, today announced the pricing of ... its common stock and warrants to purchase 50,000,000 ... to the public of $1.00 per share and ... the offering, excluding the proceeds, if any from ...
(Date:6/27/2016)... Research and Markets has announced the addition ... to their offering. The report ... to grow at a CAGR of 12.28% during the period 2016-2020. ... in-depth market analysis with inputs from industry experts. The report covers ... The report also includes a discussion of the key vendors operating ...
(Date:6/21/2016)... 21, 2016 NuData Security announced today that ... of principal product architect and that Jon ... customer development. Both will report directly to ... moves reflect NuData,s strategic growth in its product ... customer demand and customer focus values. ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... -- AskLinkerReports.com has published a report on Amyloglucosidase ... 2016 Market Research Report. From a basic outline of the ... all covered in the report. This report projects investment feasibility ... the Amyloglucosidase industry. ... , Complete report ...
(Date:12/8/2016)... ... December 08, 2016 , ... Opal Kelly, ... essential device-to-computer interconnect using USB or PCI Express, announced the FOMD-ACV-A4, the company's ... is a small, thin, SODIMM-style module that fits a standard 204-pin SODIMM socket ...
(Date:12/8/2016)... , ... December 08, 2016 ... ... the commercial launch of flexible packaging for their exceptionally efficient human mesenchymal ... system extends RoosterBio’s portfolio of bioprocess media products engineered to radically streamline ...
(Date:12/8/2016)... TAMPA, Fla. , Dec. 8, 2016 /PRNewswire/ ... biopharmaceutical company that discovers, develops and plans to ... today that its shares of common stock were approved ... stock will begin trading on the OTCQX, effective ... To qualify for the OTCQX market, companies must ...
Breaking Biology Technology: