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New technique uses 'simulated' human heart to screen drugs
Date:7/21/2014

f a million pound investment from Warwickshire-based technology investment firm Mercia Fund Management.

Dr Maddock, who spent almost ten years developing the technique, said:

"I'm delighted that our research is at a stage where we can confidently say the work-loop assay we've created is the world's only clinically relevant in vitro human model of cardiac contractility. It has the potential to shave years off the development of successful drugs for a range of treatments.

"Both the pharma industry and regulators recognise that existing methods of assessing the contractility of the heart are fraught with problems, so we're incredibly excited to be able to introduce a new way to accurately determine the safety of drugs in respect of the heart without the need to test on humans or animals."

Mark Payton, managing director of Mercia Fund Management, added:

"InoCardia benefits from a proprietary approach following many years of investigation by Helen and her team, and offers the potential for early screening of compounds in development without the initial need for extensive animal trials. Through a markedly accelerated drug development process, this will decrease timelines to drug development, and as a consequence greatly reduce the cost of new drug development. The end beneficiary will, of course, be patients receiving novel treatments sooner."

Dr Maddock and InoCardia Ltd are already in discussions with a multinational biopharmaceutical company with a view to applying the assay in industry.


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Contact: Alex Roache
alex.roache@coventry.ac.uk
44-024-776-55050
Coventry University
Source:Eurekalert  

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