Navigation Links
New technique tracks proteins in single HIV particle
Date:5/5/2014

An interdisciplinary team of scientists from KU Leuven in Belgium has developed a new technique to examine how proteins interact with each other at the level of a single HIV viral particle. The technique allows scientists to study the life-threatening virus in detail and makes screening potential anti-HIV drugs quicker and more efficient. The technique can also be used to study other diseases.

Understanding how the human immunodeficiency virus (HIV) reproduces itself is crucial in the effort to fight the disease. Upon entering the bloodstream, HIV viral particles, or virions, 'highjack' individual immune cells. The virion binds to and then penetrates the immune cell. Once inside, the virion reprograms the genetic material of the immune cell to produce more HIV virions. In this way, HIV disables the disease-fighting 'bodyguards' in our blood and turns them into breeding machines for new HIV virions.

Integrase plays a key role throughout this whole process: "Integrase is the HIV protein that causes the genetic material of HIV to link to that of the hijacked cell. It ensures the programming of the human cell upon infection. In our study, we wanted to track integrase during the different stages of infection," explains postdoctoral researcher Jelle Hendrix (Department of Chemistry). The challenge is to do this at the level of a single virion: "HIV has multiple ways of doing the same thing. This is the case for cell penetration, for instance. So it is certainly useful to be able to see exactly how the individual HIV virions are behaving."

To achieve this, the researchers used single-molecule fluorescence imaging. They engineered a genetically modified HIV virion that was capable of infecting the cell but incapable of reproducing inside it. The virion was programmed to produce a fluorescent form of integrase. "This allowed us to examine the interactions of the florescent integrase under the light microscope both in vitro in a single HIV viri
'/>"/>

Contact: Dr. Jelle Hendrix
jelle.hendrix@chem.kuleuven.be
32-016-327-344
KU Leuven
Source:Eurekalert

Page: 1 2

Related biology news :

1. Ground breaking technique offers DNA Sat Nav direct to your ancestors home 1,000 years ago
2. New technique detects microscopic diabetes-related eye damage
3. New technique will accelerate genetic characterization of photosynthesis
4. New technique takes cues from astronomy and ophthalmology to sharpen microscope images
5. Researchers develop novel molecular blood group typing technique
6. New technique brings us closer to HIV and Hepatitis C vaccines
7. New technique sheds light on human neural networks
8. New technique for identifying gene-enhancers
9. Heat-based technique offers new way to measure microscopic particles
10. NIST microanalysis technique makes the most of small nanoparticle samples
11. New technique makes biogasoline from plant waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading ... ways to more fully engage with their communities around ... industry-leading, privacy protected and secure API.  ... enables the most accessible, affordable, and convenient vehicle to ... The API will allow ...
(Date:4/8/2015)... CHARLOTTE, N.C. , April 8, 2015 /PRNewswire/ ... technology solutions and services, and Morpho, a leading ... in partnership to produce the market,s most advanced ... Infinisource,s iSolved NXG time clock is setting ... attendance and labor data for the small and ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... A new study provides support for Darwin,s ... between more closely related species than those distantly ... new study contains the strongest direct experimental evidence ... that species extinction occurred more frequently and more ...
... a better state to recall where you put them at some ... A paper describing the work is published June 13 in the ... "It,s been assumed that the process of retrieving a memory is ... UC Davis Center for Neuroscience and Department of Psychology. "But we ...
... intimate and complex relationship between inflammation and cancer; and it ... attract host cells which drive inflammation and help to support ... Press in the June issue of the journal Cancer ... trafficking of immune cells involved in inflammation. The research ...
Cached Biology News:New study supports Darwin's hypothesis on competition between species 2New study supports Darwin's hypothesis on competition between species 3Brain state affects memory recall 2Blocking common gateway to inflammation suppresses cancer 2
(Date:5/1/2015)... May 1, 2015 According ... Market by Product (Equipment, Consumables), by Type (Monoclonal, Polyclonal), ... Labs, Research Institutes) - Analysis & Global Forecast ... the global Antibody Production Market for the forecast ... expected to reach $2.572 Billion by 2019 from ...
(Date:4/30/2015)... 2015 Spirax Sarco, the leader in ... to announce that for the first time in the ... of a Queen’s Award for Innovation – the UK’s ... manufacture of a unique flowmeter. , The Spirax Sarco ... traditional steam flow measurement. The device provides reliable, ...
(Date:4/30/2015)... , April 30, 2015   Tamir Biotechnology ... today an update on its Ebola antiviral therapy program. ... leading candidates, TMR004, is currently being evaluated and considered ... the battle against Ebola. During the first quarter of ... Leadership Meeting To Accelerate The Evaluation of Potential Treatments ...
(Date:4/30/2015)... /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), an ... has commenced an underwritten public offering of its common ... a 30-day option to purchase up to an additional ... in the public offering. The offering is subject to ... to whether or when the offering may be completed, ...
Breaking Biology Technology:Antibody Production Market worth $2.572 Billion by 2019 2Antibody Production Market worth $2.572 Billion by 2019 3Antibody Production Market worth $2.572 Billion by 2019 4Spirax Sarco Receives a Queen’s Award for Innovation 2Spirax Sarco Receives a Queen’s Award for Innovation 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4BioAmber Inc. Announces Public Offering Of Common Stock 2BioAmber Inc. Announces Public Offering Of Common Stock 3
... April 1, NovaBay Pharmaceuticals, Inc. (NYSE Amex: ... developing first-in-class anti-infective products for the treatment and ... causing resistance, reported today its financial results for ... 31, 2008. The company also announced clinical ...
... Submits Contract Proposal to Further Develop Environmental Biosensor ... Biomedical, Inc., a leader in human embryonic stem ... submitted a Department of Defense contract proposal to ... cell technology. (Logo: ...
... 1 /PRNewswire-Asia-FirstCall/ -- Yongye Biotechnology,International, Inc. (OTC Bulletin ... of nutrients for plants and animals, located in ... named Mr. Sam Yu to be the,Company,s new ... Mr. Yu,replaces Larry Gilmore, who served as the ...
Cached Biology Technology:NovaBay Pharmaceuticals, Inc. Announces Fourth Quarter and Full Year 2008 Financial Results 2NovaBay Pharmaceuticals, Inc. Announces Fourth Quarter and Full Year 2008 Financial Results 3NovaBay Pharmaceuticals, Inc. Announces Fourth Quarter and Full Year 2008 Financial Results 4NovaBay Pharmaceuticals, Inc. Announces Fourth Quarter and Full Year 2008 Financial Results 5NovaBay Pharmaceuticals, Inc. Announces Fourth Quarter and Full Year 2008 Financial Results 6NovaBay Pharmaceuticals, Inc. Announces Fourth Quarter and Full Year 2008 Financial Results 7NovaBay Pharmaceuticals, Inc. Announces Fourth Quarter and Full Year 2008 Financial Results 8NovaBay Pharmaceuticals, Inc. Announces Fourth Quarter and Full Year 2008 Financial Results 9ArunA Biomedical Submits Contract Proposal to Further Develop Environmental Biosensor for National Security 2Yongye Biotechnology Appoints New Chief Financial Officer 2Yongye Biotechnology Appoints New Chief Financial Officer 3
MAb to Desmoplakin I & II Desmoplakin I & II...
BD Biocoat Matrigel Matrix Thin Layer 35 mm Culture Dishes...
... Activation of ICE-family proteases/caspases initiates apoptosis in ... Apoptosis Detection Kit provides a simple and ... by flow cytometry in intact cells. ... two aspartate residues linked to rhodamine 110 ...
... pLivSelect is a direct antibiotic-based selection system ... on colony survival, eliminating the need for ... process provides close to 100% accuracy in ... platform for robot colony picking. This cloning ...
Biology Products: