Navigation Links
New technique reveals subtle force-induced changes in biomolecule's conformation
Date:10/16/2007

ed laser beam locks onto a microsphere attached to one end of the molecule to be studied. The optical trap can then pull on the molecule like a pair of tweezers.

The project is funded by the Physics and Molecular and Cellular Biosciences divisions at the National Science Foundation (NSF) through a CAREER award for the development and utilization of advanced single-molecule techniques to study the fundamentals of DNA-protein interactions.

Past techniques, such as X-ray crystallography and nuclear magnetic resonance, have provided a vast amount of structural detail for biological molecules, but the data is largely limited to a static view. Single molecule approaches make it possible to study dynamic interactions at the single molecule level. The ability to follow bioprocesses as they actually occur in real time transforms the way we visualize and ultimately understand the complex dynamics of living systems.

"The two NSF divisions supporting this project have been working closely together for several years to foster this research and other similar approaches," said NSF Program Manager Denise Caldwell. "These results highlight the importance of fostering a cross-disciplinary approach to understanding complex living systems because input from both directions is essential to the success of the project." She added that "a lot of junior scientists are migrating into fields like this one because the science is intellectually exciting."


'/>"/>

Contact: Diane Banegas
dbanegas@nsf.gov
703-292-4489
National Science Foundation
Source:Eurekalert

Page: 1 2

Related biology news :

1. New Technique for Tracking Gene Regulators
2. Live Recombinant Adenovirus Vaccine Technique Explored
3. New lab technique identifies high levels of pathogens in therapy pool
4. Brain-mapping technique aids understanding of sleep, wakefulness
5. Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
6. Study reveals new technique for fingerprinting environmental samples
7. Researchers Find New Technique To Identify Fetal Genetic Material From Amniotic Fluid
8. Researchers pioneer new gene therapy technique using natural repair process
9. Newer imaging techniques may lead to over-treatment
10. Gene silencing technique offers new strategy for treating, curing disease
11. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... about what they eat, the Food and Drug Administration ... Nutrition Facts label found on nearly every food product ... Engineering News (C&EN), the weekly news magazine of ... and the fight that has ensued. , Britt Erickson, ... the Nutrition Facts label has remained largely the same ...
(Date:7/30/2014)... major interest in neuroscience. A large number of ... of Wallerian degeneration: transcription factor activation, immune response, ... responses in the distal segment of the sciatic ... in gene expression between the proximal and distal ... from Nantong University, China used microarrays to analyze ...
(Date:7/30/2014)... Calif. , July 30, 2014 ... with the United States Air Force Research Laboratory ... by Binghamton University to ... performance monitoring (HPM). The $425,000 project, with contributions ... packaging firm i3 Electronics, Inc. ( Endicott, ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 3
... Nature Genetics, is based on data from more than ... but also discovered ten new genes. Altogether they explain ... The analysis produced some biologically insightful findings. Several ... let-7, which affects the regulation of other genes. This ...
... University of Leicester engineer has won a share of ... cancer. In an unusual move, Dr. Declan Bates, ... the University of Leicester, is co-recipient of 1,068,000 in ... the Engineering and Physical Sciences Research Council (EPSRC) and ...
... to determine if global warming threatens the polar bear population ... listing the polar bear as an endangered species, according to ... journal of the Institute for Operations Research and the Management ... ordered the Interior Department to decide by May 15 whether ...
Cached Biology News:How body size is regulated 2Engineer to spearhead research into cell metabolism and medical injuries 2Federal polar bear research critically flawed, says study in INFORMS journal 2
(Date:7/30/2014)... and PARIS , July ... Sanofi (EURONEXT: SAN and NYSE: SNY) today announced that ... Drug Administration (FDA) rare pediatric disease priority review voucher ... for alirocumab.  The priority review voucher entitles the holder ... for an expedited 6-month review from the filing date ...
(Date:7/30/2014)... 30, 2014 A study presented at ... and efficacy of CSL Behring,s C1 Inhibitor (C1-INH) ... in highly sensitized patients. C1-INH is a human ... system. The study shows that post-transplant ... the levels of complement components 3 and 4, ...
(Date:7/30/2014)... July 30, 2014 While administrative ... health services research for a relatively long period ... interest regarding the use of these ‘big data’ ... , By combining today’s powerful computer technology with ... era, ‘big data’ holds significant promise for identifying ...
(Date:7/30/2014)... 30, 2014   Wyle has been ... Lifecycle Mission Support Services (FILMSS) contract awarded by ... the terms of the contract, Wyle will provide ... Field, Calif. In particular, Wyle will provide program ... projects on the International Space Station and collaborative ...
Breaking Biology Technology:Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2
... 26 Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: OXBO) today ... the addition of two new members. Appointed to the company,s ... Chatfield. With their addition, the company board now has eight ... of the U. S. Selective Service System from November of ...
... Pa., Oct. 26 Cadient Group , ... today announced that it has been recognized as one of ... the Greater Philadelphia region for the second consecutive year. ... during the five year period from 2004-2008. Cadient Group ...
... , ... blue dye test alternative using innovative laser technology has been installed at ... processes. Bayer China has acquired Sepha ’s ‘BlisterScan’ machines for non-destructive leak testing ... ...
Cached Biology Technology:Oxygen Biotherapeutics, Inc. Expands Board of Directors 2Cadient Group Ranks as Deloitte Fast 50 Company for Greater Philadelphia Region for Second Consecutive Year 2Blue Dye Test Alternative Installed at Bayer China for Packaging Quality Assurance Process 2Blue Dye Test Alternative Installed at Bayer China for Packaging Quality Assurance Process 3
... is an aqueous solution that contains a ... chemicals in a saline solution, pH 6.5 ... 0.02% methylisothiazolone and 0.02% bromonitrodioxane as a ... diluent and stabilizer for biologically active components ...
... clarification reagent; Ideal for clarifying many ... proteins, nucleic acids, & proteoglycans; Contains ... improves downstream processing; Utilizes a reagent ... supplied as a suspension in saline; ...
... StabilGuard Biomolecule Stabilizer is a bovine ... It is an aqueous solution that contains ... buffered saline), pH 6.6 - 7.2, and ... product maintains the activity of antibodies and ...
A simple, sensitive and reliable method for determining free sulfhydryl content in peptides, protein...
Biology Products: