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New technique is quantum leap forward in understanding proteins
Date:12/23/2008

teract with themselves, there were 23 correct pairings identified before a first false positive.

"Based on test models so far, it appears that the method is absolutely, astonishingly accurate," says Szurmant.

The next step, already under way, is to use the message passing in the drug discovery process. The two-component signaling system is responsible for countless essential functions in bacterial cells including adjustment to growth conditions, and can control virulence. That means interruption of strategic direct interactions can kill pathogenic bacteria. Though many direct interactions in the system had been identified, the message-passing work has also identified new ones.

The message-passing technique is dependant on the availability of extensive genomic data, and some 800 or so bacterial genomes have been fully sequenced. But applying message passing to animals will have to wait until a similar volume of genomic data is available for them. Ultimately, some form of the technique could identify important protein interactions in humans, which would open a wealth of new drug targeting possibilities.


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Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

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