Navigation Links
New technique is quantum leap forward in understanding proteins
Date:12/23/2008

interactions is a statistical method known as covariance, and the Scripps Research-UCSD team's new method relies on this as a foundation. Covariance analysis of proteins involves studying the amino acids found at specific locations on various protein sequences culled from genomics data. Covariance analysis between two proteins identifies residue positions that vary together from residue positions that vary at random.

Covariance has proven quite effective at identifying critical residues that bind directly with other proteins or other spots on the same protein, which is the goal. But, unfortunately, the method also identifies a high percentage of residues that turn out to not be involved in these direct interactions. Research groups have developed various techniques to winnow out such indirect interactions, but with only limited successuntil now.

Outside Help

Years ago, frustrated by the inadequacy of available techniques, Hoch and his colleagues set out to find some means beyond the normal bounds of biology to solve the problem of identifying the directly interacting protein residues without crystallography. The search eventually brought them to Professor Terry Hwa at UCSD and Martin Weigt, an expert in a computational technique known as message passing, in Turin, Italy. This method, used mainly in an area known as spin glass physics, is a computer-intensive means of finding patterns in certain types of data.

For the first test of message passing with proteins, the group focused on the proteins involved in the well-studied two-component signaling system, which is responsible for a range of critical functions in bacteria. The first step of the work was to analyze the countless proteins involved in this system applying standard covariance techniques to available genomics data. The full analysis included about 2,500 different protein pairings and considered the potential interactions between about 100 residues on each protein
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
7. New X-ray technique targets terrorists and tumors
8. Technique controls nanoparticle size, makes large numbers
9. New technique could dramatically lower costs of DNA sequencing
10. New techniques create butanol
11. New radar satellite technique sheds light on ocean current dynamics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market, announces it ... Conference on January 29 th at 10:30 a.m. ... of NXT-ID will present and host a live Q&A ... and its full suite of biometric technologies. Investors can ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ( ... - A Global Market Overview" report to their offering. ... is to ensure that an individual is who she/he is ... make use of a person,s unique physical characteristics, such as ...
(Date:1/22/2015)... Technology Showcase, Hall E -   EyeLock Inc. , ... it will showcase its EyeLock ID technology integrated in a ... Energy,s Oak Ridge National Laboratory (ORNL) at the ... identity authentication technology is being used to validate the driver ...
Breaking Biology News(10 mins):CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3
... CHAMPAIGN, Ill. We all know one, or think we ... his or her actual merits. Popular culture labels these folks ... suggests that some forms of narcissism are at least ... difficult transition to adulthood. The study appears ...
... relatively simple combination of naturally occurring sugars and amino acids ... according to a paper published in Nature Chemistry ... The study, " A Route to Enantiopure RNA Precursors ... to RNA could have formed on Earth before any life ...
... --- Farmers and policymakers should wait before converting Conservation Reserve ... Michigan State University study. The study, which appears ... National Academy of Sciences , focuses on CRP land, a ... than crops, and its role in the production of biofuels. ...
Cached Biology News:Narcissism may benefit the young, researchers report; but older adults? Not so much 2To avoid carbon debt, CRP beats fields of corn, soybeans 2
(Date:2/26/2015)... IRVINE, Calif. , Feb. 26, 2015 /PRNewswire/ ... of age-defying aesthetic products for skin and hair ... Market Relations as agency of record for investor ... continues to improve our distribution, sales and diversification ... activities to current and prospective shareholders," stated Ali ...
(Date:2/26/2015)... (PRWEB) February 26, 2015 The ... -12, at the Ernest N. Morial Convention Center ... (count as of February 19, 2015) displaying products ... industrial, academic, and government labs. The Exposition will ... but not limited to, analytical chemistry; drug discovery; ...
(Date:2/26/2015)... Frederick, MD (PRWEB) February 26, 2015 ... solutions provider, released FreezerPro® version 6.2 – the latest ... The FreezerPro® reputation is that of a quick and ... related work. With the latest version, RURO engineering has ... on import to move large amounts of sample records. ...
(Date:2/26/2015)... Regis Technologies announced new potent ... drug substances. , Regis Technologies is proud to announce ... Compound Suite (PCS) for 2015. , Regis is a ... facility in Morton Grove, Illinois. The PCS addition will ... up to about one kilogram per batch. , ...
Breaking Biology Technology:NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3Pittcon 2015 Announces Exposition Highlights 2RURO Releases FreezerPro® version 6.2 2Regis Extends cGMP Services to Oncology Market 2
... Jan. 8 Substantial progress and,momentum behind its research-and-development ... deliver several new blockbuster products to farmers,by 2012, company ... part of a series of presentations on the company,s ... to see such innovation in the pipeline right now," ...
... would, strengthen Elekta,s offering and accelerate the company,s expansion ... ... Elekta AB (publ) (STO: EKTAb),a world leader in clinical solutions ... exclusive negotiations based on,a Letter of Intent to acquire CMS ...
... and patients of,community-based medical practices in ... partnership between Physicians Practice and Loma ... help local physicians manage their,practices more ... (Logo: http://www.newscom.com/cgi-bin/prnh/20070904/NETU093LOGO ), Under ...
Cached Biology Technology:Monsanto's R&D Pipeline Set to Deliver Valuable Products to Farmers Well Into Next Decade 2Monsanto's R&D Pipeline Set to Deliver Valuable Products to Farmers Well Into Next Decade 3Elekta Negotiates To Acquire CMS 2Elekta Negotiates To Acquire CMS 3Elekta Negotiates To Acquire CMS 4Elekta Negotiates To Acquire CMS 5Physicians Practice, Loma Linda Partner to Improve Patient Care in Southern California 2
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... Yeast Oligo Microarray Kit (V2), 2 ... simultaneously characterize expression of many thousands ... activity during important biological processes. Each ... 6,256 known ORFs from the S288C ...
... an intuitive, easy-to-use operating environment ... data handling, and integration with ... include data acquisition, re-analysis, custom ... both standalone and network environments. ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
Biology Products: