Navigation Links
New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome
Date:2/1/2009

Chemotherapy is an integral part of modern cancer treatment, but it's not always effective. Successful chemotherapy depends on the ability of anticancer drugs to escape from the bloodstream through the leaky blood vessels that often surround tumors.

Predicting chemotherapy's efficacy could save thousands of individuals from unnecessary toxicity and the often difficult side effects of the treatments.

In a study published in the February issue of the journal Radiology, researchers describe a technique for determining the "leakiness" of tumor blood vessels using a simple digital mammography unit. The researchers designed nanometer-sized capsules containing a contrast agent that could only leak into tumors with blood vessels that were growing and therefore leaky. The digital mammography-based quantification of "leakiness" is closely correlated to the ability of a clinically approved chemotherapy agent to enter the tumor, allowing the researchers to predict the agent's therapeutic efficacy.

"We developed a quantitative way to measure the leakiness of the blood vessels, which is directly linked to the amount of drug that gets to the cancer and in turn determines effectiveness," said Ravi Bellamkonda, a professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. "By simply measuring how much contrast agent reaches the tumor, we can predict how much of a clinically approved chemotherapeutic will reach the tumor, allowing physicians to personalize the dose and predict effectiveness."

In some cases, one chemotherapy drug may not be effective in treating the tumor, but this new technique allows oncologists to investigate other drugs sooner since they know the drug is reaching the tumor. Studies are currently underway to determine if mammography can predict the optimal dose of a wide range of breast cancer chemotherapeutics.

Bellamkonda and Coulter Department postdoc
'/>"/>

Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. U of T technique put to use to test clean up of contaminated groundwater
2. New satellite techniques for looking at climate change
3. New computational technique allows comparison of whole genomes as easily as whole books
4. Novel technique changes lymph node biopsy, reduces radiation exposure
5. Novel technique changes lymph node biopsy, reduces radiaiton exposure
6. New technique is quantum leap forward in understanding proteins
7. New edition of laboratory manual includes cutting-edge techniques to study gene regulation
8. Novel technique for fluorescence tomography of tumors in living animals
9. These shells dont clam up: Innovative technique to record human impact on coastal waters
10. Einstein researchers develop technique to count messages made by single genes
11. These shells dont clam up: Innovative technique to record human impact on coastal waters
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/st5b3m/saudi_arabia ) has ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Arabia Biomedical Sensors market is estimated at $0.23 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
(Date:8/25/2015)... and BELLEVUE, Wash. , ... in advanced robotic systems, announced today it will unveil ... ground vehicle (UGV), at the National Tactical Officers Association ... The Guardian S is the first-ever commercially ... of years of research and in-field trials and is ...
(Date:8/20/2015)... PLEASANTON, Calif. , Aug. 20, 2015 /PRNewswire/ ... focused on consumers that are active and healthy. ... used in the hospital environment to help improve ... released a video from the Wearable Technologies ... MD discussed new applications for wearables in healthcare.    ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3
... , Oct. 15, 2013 Medbox, Inc. (OTC ... industry specific consulting services and patented systems to the ... sheet with a medical marijuana research and development laboratory ... terms, Medbox has been engaged in an ongoing consulting ...
... 2013 Babcock Genetics, Inc., a worldwide supplier of swine ... a new genetic program available to swine producers. ... that would offer a higher level of profitability to our ... . "We are maximizing genetic improvement by selecting lines that ...
... cities is often an overlooked resource. Years of manufacturing or ... scare residents away from using the land. As the local ... desire to grow food in cities with the fear that ... 10:35 am, Kristen McIvor of the Pierce Conservation District will ...
Cached Biology News:Medbox Partners with Licensed Medical Cannabis Laboratory and Cultivation Center in Canada 2Medbox Partners with Licensed Medical Cannabis Laboratory and Cultivation Center in Canada 3Medbox Partners with Licensed Medical Cannabis Laboratory and Cultivation Center in Canada 4Fostering community gardens in an area with historic soil contamination 2
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ) has announced the ... Growth, Trends & Forecasts (2014-2020)" report to their ... market is estimated at $0.20 billion by 2018 at ... The near future will bring biomedical sensors that ... These sensors can be set to trigger alerts when ...
(Date:8/31/2015)... , Aug. 31, 2015  For people with ... brighten their day. The biotechnology company, located in the ... one of the best potential therapies yet for people ... entitled, " Correction of Down syndrome and Edwards syndrome ... journal DNA Research . Elixirgen plans to develop ...
(Date:8/31/2015)... , Aug. 31, 2015  US-Australian drug ... NVGN ) today confirmed its comprehensive scientific review ... technology platforms in areas of unmet patient need. ... the remaining preclinical projects prior to entering into ... compounds. Acting Chief Executive Officer, ...
(Date:8/31/2015)... LabStyle Innovations Corp. (OTCQB: DRIO), developer ... it recently closed a round of funding totaling ... support the global rollout and initial U.S. commercial ... management solution that includes novel software applications combined ... device, and for working capital purposes. The Dario ...
Breaking Biology Technology:Mexico Biomedical Sensors Market Report 2015-2020 2New Down syndrome therapy discovered 2Novogen Announces The Outcome Of A Comprehensive Science Review 2Novogen Announces The Outcome Of A Comprehensive Science Review 3Novogen Announces The Outcome Of A Comprehensive Science Review 4Novogen Announces The Outcome Of A Comprehensive Science Review 5Novogen Announces The Outcome Of A Comprehensive Science Review 6LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 2LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 3LabStyle Innovations Closes $2.5 Million Funding to Support Global Rollout of Dario Diabetes Management Solution 4
... announced that its executives will be speaking at the following,investor conferences, ... Credit Suisse Global Health Care Conference, Phoenix, AZ ... Mountain Time, Piper Jaffray Health Care ... 2, 2008 at 2.00 p.m. Eastern Time Accessing Webcasts, ...
... (Nasdaq: KOOL ), a leading supplier of innovative ... that it will be,participating in the Rodman & Renshaw ... The Company,s presentation by Dr. William Osgood, the Company,s ... am, Pacific Standard,Time), and will be held at the ...
... role in causing asthma. Now, a team of researchers ... noninvasively visualize in real-time eosinophil responses in the lungs ... asthma (experimental allergic airway inflammation); they hope that these ... of treatments (both old and new) for the disease. ...
Cached Biology Technology:Cepheid to Webcast Upcoming Financial Presentations 2ThermoGenesis Presentation at Rodman & Renshaw Conference 2
... 0.7 mm depth • Reusable, press-to-seal gasket ... quickly assembled and disassembled for hybridizing and ... any thickness with up to a 13 ... per slide. Minimize specimen handling, eliminate evaporation ...
Comp Dim: chamber diam. depth 20 2.8 mm chamber maximum volume 720 μL...
...
... direct, simple approach to covalently ... surface of an EIA plate ... its integrity and availability for ... room temperature conditions Open ...
Biology Products: