Navigation Links
New technique identifies pathogens in patient samples faster, in great detail
Date:12/2/2013

A team of Danish investigators has shown how to identify pathogens faster, directly from clinical samples. The research, published online ahead of print in the Journal of Clinical Microbiology appears in the journal's January 2014 issue.

The investigators used a technique known as whole genome sequencing to identify and completely characterize bacteria causing urinary tract infections. In just 18 hours, they identified the culprit microorganisms, characterized the pathogens' patterns of antibiotic susceptibility, and identified specific strains.

"Using conventional methodologies this would have taken several days to weeks, and even using whole genome sequencing on cultured bacteria would have taken an extra day," says Frank M. Aarestrup of the Technical University of Denmark, Lyngby, an author on the study.

Their work will help patients heal more quickly and avoid unnecessarily prolonged illness and even death. It will also help prevent outbreaks of hospital-acquired disease, and identify emerging infections.

"Rapid identification of the causative agent, and of any antibiotic resistance is crucial to choosing the correct treatment for individual patients," says Aarestrup. "Choosing the wrong antibiotic will lead to longer infections and in the worst case, deaths."

The investigators also identified bacteria in the patient samples that they did not detect using conventional techniques. "Lactobacillus iners, Gardnerella vaginalis, Prevotella, and A. urinae have all been implicated in [urinary tract infections], even though their precise roles as pathogens and normal colonizers of the genital tract have not been firmly established," write the researchers. They note that by conventional methods A. urinae is rarely identified but frequently misclassified.

The ability to identify strains in patients with repeated infections enables the doctor to know whether the patient's infection is new, or recurrent. And the typing of bacterial strains enables rapid comparison of bacteria from different patients, so that doctors can detect the spread of infections within the hospital, and identify emerging infections.

"Whole genome sequencing may still be too expensive for routine use in most clinical microbial laboratories," the researchers write. But they predict that rapidly falling prices and automation will render it a standard technology for infection detection and control, in and out of the hospital.


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Related biology news :

1. Integrated pest managment techniques can help manage the Bagrada bug
2. New technique for testing drugs to treat cystic fibrosis and epilepsy
3. UT Dallas computer scientists create 3-D technique
4. New technique controls dimensions of gold nanorods while manufacturing on a large scale
5. New technique for developing drugs to treat serious illnesses
6. Novel technique for suturing tissue-engineered collagen graft improves tendon repair
7. EUREKA grant to fund development of new optogenetic technique for mapping neural networks at UMMS
8. Research reveals bottom feeding techniques of tagged humpback whales in Stellwagen Bank Sanctuary
9. New technique for measuring tree growth cuts down on research time
10. New gene repair technique promises advances in regenerative medicine
11. First child born following embryo screening with new genome analysis technique
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... ... September 21, 2017 , ... Executives ... the world’s most progressive pharma and biotech organizations to do more clinical trials ... and biotech events in Q4. , DrugDev will demonstrate DrugDev Spark™, the world’s ...
(Date:9/21/2017)... DIEGO, CALIF. (PRWEB) , ... September 21, 2017 , ... ... earlier this month. The organization, a worldwide society of professional women with high ... venue to hold its annual dinner. , Twelve members began with an ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... appointed Vishwas Paralkar to the role of chief scientific officer. In this role, ... report to Cybrexa’s president and CEO, Per Hellsund. , “I was impressed with ...
(Date:9/20/2017)... ... September 20, 2017 , ... Proscia Inc. ... , a provider of whole slide imaging solutions, are hosting a pre-conference workshop ... entitled “Successfully Deploying a Best-in-Class Strategy for Digital Pathology,” will feature Proscia CEO, ...
Breaking Biology Technology: