Navigation Links
New technique for developing drugs to treat serious illnesses
Date:11/14/2013

An international team of researchers led by the University of Leicester has "harnessed the power of evolution" to create a new drug for possible use against heart disease, inflammation and other illnesses.

Researchers in the Department of Cardiovascular Sciences and Department of Biochemistry at the University of Leicester, together with colleagues in Cambridge, the USA and Italy, have employed a new technique to create protein-based drugs.

According to Professor Nick Brindle, the lead researcher: "This technique harnesses the power of evolution to engineer specific functions into a protein, such as the ability to neutralise a toxin or to activate healing.

"This involves making a particular cell type generate millions of different variants of our protein, selecting the variants that have improved properties and then repeating the cycle until the protein has been changed to a form with the exact properties we want."

To show how the method works, the group took a protein normally found in the body and evolved it into a form that can block a molecule involved in blood vessel growth and inflammation.

This new protein, called a ligand-trap, is now being developed as a potential therapeutic for treating heart disease, inflammation and other illnesses.

Said Professor Brindle: "The idea that you can evolve proteins into forms that do what you want is not new, but it has been very difficult to do this for many of the complex proteins that we want to use as drugs or for other applications.

"This new approach promises to make engineering of such proteins not only possible but relatively easy. In addition to medicine, these specifically evolved 'designer proteins' have a wide range of applications in the chemical, pharmaceutical, and agricultural industries.

"This is a big step forward. We are hoping that, over the next five years or so, this new protein can be developed into a form that could be
'/>"/>

Contact: Nick Brindle
npjb1@mail.cfs.le.ac.uk
01-162-297-170
University of Leicester
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Novel technique for suturing tissue-engineered collagen graft improves tendon repair
2. EUREKA grant to fund development of new optogenetic technique for mapping neural networks at UMMS
3. Research reveals bottom feeding techniques of tagged humpback whales in Stellwagen Bank Sanctuary
4. New technique for measuring tree growth cuts down on research time
5. New gene repair technique promises advances in regenerative medicine
6. First child born following embryo screening with new genome analysis technique
7. New palm-sized microarray technique grows 1,200 individual cultures of microbes
8. UMass Amherst researchers develop powerful new technique to study protein function
9. Computer modeling technique goes viral at Brandeis
10. CLEO: 2013 press luncheon spotlights new techniques in optofluidics, temporal cloaking, cryolasers
11. New screening technique paves the way for protein drugs from bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New technique for developing drugs to treat serious illnesses
(Date:12/17/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) ... Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this ... in biomedical applications. Chemical sensors help in recording ... during surgical procedures. The Global Chemical Sensor market ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ... accuracy is the ultimate driver in long-term mass consumer ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... category for the largest human-designed protein, then a team of ... have designed and successfully synthesized a variant of a protein ... It is more than twice the size of the previous ... of Washington in 2003. The synthetic protein, designated FLR, ...
... A study conducted by researchers at the Johns Hopkins ... patterns of drug resistance in malaria-causing parasites taken from ... in human blood samples showed a high prevalence for ... widely used to treat malaria in the region. However, ...
... CHAPEL HILL, N.C. After a heart attack, the portions ... scar tissue. Researchers have long sought ways to avoid this ... its ability to pump blood throughout the body and eventually ... of North Carolina at Chapel Hill School of Medicine shows ...
Cached Biology News:Creation of the largest human-designed protein boosts protein engineering efforts 2Creation of the largest human-designed protein boosts protein engineering efforts 3Contrasting patterns of malaria drug resistance found between humans and mosquitoes 2Scarring a necessary evil to prevent further damage after heart attack 2
(Date:12/24/2014)... PARIS and NEW YORK ... data from its open-label pilot study of mazindol in ... Design, Development and Therapy in December 2014 . ... of mazindol in children with attention deficit/hyperactivity disorder" ( ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) ...
(Date:12/22/2014)... 2014  Alternative Energy & Environmental Solutions, Inc., ... a letter of intent to acquire BioTechPharma Corporation, ... a nanotechnology-based development platform used to create drug ... on-site collection and testing to identify infectious disease, ... an immediate, non-invasive and cost-effective manner. ...
(Date:12/22/2014)... 22, 2014 ITRA Global, one of ... of commercial real estate, has further expanded its global ... Perth and Brisbane, Western Australia, reports Mylinda Vick, CCIM, ... ITRA Global / ACORPP (Australian Corporate Property and ... company providing property services to a wide range of ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the ... Maroulis, Pharm.D. to the newly created position of Vice ... position, Dr. Maroulis will continue to manage the entire ... multi-site pharmacies as the company expands. Dr. Maroulis has ... he has served in many different capacities in the ...
Breaking Biology Technology:Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3ALNE Announces Intention To Acquire BioTechPharma 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... fight cancer, rheumatoid arthritis, as well as enhance ... CEL-SCI Corporation (NYSE Amex: CVM ) ... 11th annual National Foundation of Infectious Diseases Conference ... L.E.A.P.S.(TM) (Ligand Epitope Antigen Presentation System) vaccine technology ...
... April 27 MannKind Corporation (Nasdaq: MNKD ... on Monday, May 4, 2009.Management of the Company will ... financial results and other Company developments at 4:00 PM ... will be its Chairman and Chief Executive Officer, Alfred ...
... SAN DIEGO, April 27 Cadence Pharmaceuticals, Inc. (Nasdaq: ... clinical trials of its investigational product candidate, Acetavance(TM) (intravenous ... Regional Anesthesia and Pain Medicine (ASRA) 34th Annual Regional ... and at the Society of Hospital Medicine (SHM) Annual ...
Cached Biology Technology:CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease 2CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease 3CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease 4MannKind Corporation to Hold First Quarter Financial Results Conference Call on May 4, 2009 2Cadence Pharmaceuticals Announces Presentations at Upcoming Scientific Conferences 2
... DNA Polymerase is a premium quality recombinant ... thermostable enzyme is suitable for a wide ... highest purity and reproducible performance, each preparation ... quality control assays. NovaTaq DNA Polymerase possesses ...
... cell sorter sets a new standard for ... a revolutionary new design in instrumentation, this ... multicolor analysis. The BD FACSAria instrument is ... fixed-alignment cuvette flow cell. This new ...
Mouse monoclonal antibody raised against a partial recombinant COG2. NCBI Entrez Gene ID = COG2...
Mouse polyclonal antibody raised against a partial recombinant IFNA13. NCBI Entrez Gene ID = 3447...
Biology Products: