Navigation Links
New technique for cancer screening
Date:2/23/2009

Graz, Austria Current research suggests that a new technique to determine tumor methylation status can be used in archived tissue samples. The related report by Balic et al, "High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis," appears in the March 2009 issue of The Journal of Molecular Diagnostics.

DNA in tumors is often altered compared with DNA in normal tissues. One common DNA alteration in cancerous tissue is hypermethylation, which results in loss of gene expression. The difference in methylation between normal and cancerous tissues can be used as a biomarker for early cancer diagnosis, risk assessment, and response to therapy.

Archival tissues, or tissues that are formalin-fixed and paraffin-embedded for long-term storage, are difficult to screen for cancer biomarkers due to the low quality of their DNA. It is therefore important to develop new techniques to screen for DNA methylation that can be used in archival tissues.

Balic and colleagues examined the ability of high-resolution melting analysis (HRM) to detect methylation on archival tissues from colorectal cancer patients. They found that HRM provided similar results between archival and fresh tissues. In addition, they validated the results using the widely used MethyLight assay.

The results by Balic et al "add substantial information on the HRM-based DNA methylation analysis and demonstrate its applicability for analysis of archival tissues." This assay can be used to establish risk stratification of patients based on methylation status of specific markers and, due to its high sensitivity may have the potential to detect low amounts of methylated cells within the tumor, or even to detect low numbers of tumor cells in the background of non-tumor cells in lymph nodes and other organs. Most importantly, because formalin fixation and paraffin embedding are
'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2

Related biology news :

1. New technique images tumor vessel leakiness to predict breast cancer chemotherapy outcome
2. U of T technique put to use to test clean up of contaminated groundwater
3. New satellite techniques for looking at climate change
4. New computational technique allows comparison of whole genomes as easily as whole books
5. Novel technique changes lymph node biopsy, reduces radiation exposure
6. Novel technique changes lymph node biopsy, reduces radiaiton exposure
7. New technique is quantum leap forward in understanding proteins
8. New edition of laboratory manual includes cutting-edge techniques to study gene regulation
9. Novel technique for fluorescence tomography of tumors in living animals
10. These shells dont clam up: Innovative technique to record human impact on coastal waters
11. Einstein researchers develop technique to count messages made by single genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... is a complex congenital central nervous system disease ... the neural tubes during the embryonic phase. Many ... fecal incontinence and neurocognitive retardation. Such problems decrease ... life. Researchers at Ankara Physical Medicine and Rehabilitation ... performance in children with SB, using the Pediatric ...
(Date:7/25/2014)... girls reach puberty is influenced by ,imprinted genes,a subset of ... gene. This is the first evidence that imprinted genes ... of this study were published today in the journal ... menarche, is a marker for the timing of puberty in ... varies between girls, is an inherited trait, and is linked ...
(Date:7/25/2014)... a molecular testing panel developed at UPMC greatly ... surgery for patients with thyroid nodules and cancer, ... Institute (UPCI), partner with UPMC CancerCenter., The test, ... other diagnostic testing agencies, improved the chances of ... percent, according to the study published this month ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3
... European College of Neuropsychopharmacology (ECNP) is pleased to ... 2009 ECNP Neuropsychopharmacology Award in Basic Science Research ... into the neurochemical basis of substance addiction. ... in the field of neuropsychopharmacology and its closely ...
... Researchers have made significant advances in the treatment of metastatic ... treat successfully once it has started to spread according ... congress, ECCO 15 ESMO 34 [1], in Berlin on ... seen rapid and dramatic shrinking of metastatic tumours in patients ...
... research team at the National Institute of Standards and ... possible cancer therapy has uncovered a delicate balancing act ... says they should be. Just like individuals in a ... because they get close together, but not too close. ...
Cached Biology News:Trial of new treatment for advanced melanoma shows rapid shrinking of tumors 2Trial of new treatment for advanced melanoma shows rapid shrinking of tumors 3Therapeutic nanoparticles give new meaning to sugar-coating medicine 2
(Date:7/25/2014)... 25, 2014 Lawrence Livermore scientists Charles ... Reuters list of " The World's Most Influential Scientific ... the 3,000 researchers who were identified by analyzing citation ... who published the highest-impact work (2002-2012 and 2012-2013). The ... combustion modeling . , "This recognition is a ...
(Date:7/25/2014)... July 25, 2014 Sinovac Biotech Ltd. (Nasdaq: ... China , today announced that it will ... June 30, 2014, after market close on Thursday, August 14, ... to the market opening on Friday, August 15, 2014, at ... China Standard Time) to review the Company,s financial results and ...
(Date:7/24/2014)... , July 24, 2014  Now available is ... home. Rehealth Regenerative Therapies , located in ... other physically active people a new health option: ... Regardless of age, countless patients suffer from joint and ... such as muscle tears, torn rotator cuff, tennis elbow, ...
(Date:7/24/2014)... A research team led by group leader Yung-Eun ... technology to synthesize sulfur-doped and nitrogen-doped graphenes which ... secondary batteries and fuel cells. Yung-Eun Sung is ... Nanoparticle Research at Institute for Basic Science* (IBS) ... , This achievement has great significance with regards ...
Breaking Biology Technology:Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3
... Researcher Appreciation Event ... ... PHOENIX, Oct. 3 ThirdBiotech Inc., http://www.thirdbiotech.com, a biotechnology incubator ... Appreciation Event to be held on Thursday, October 23rd, 2008,between noon and ...
... http://www.amdl.com ),AMDL, Inc. (Amex: ADL ), a leading ... the US, today announced that the,Company will present at ... on Tuesday, October 7, 2008 at 10:30 a.m. ET. ... York Hotel in the Morosco Room., The Maxim ...
... Support R&D Efforts and Clinical Trials Advancing,the ... Oct. 3 Micromet, Inc. (Nasdaq:,MITI) ("Micromet" ... proprietary antibodies for the treatment of cancer, ... has closed its previously,announced $40 million private ...
Cached Biology Technology:First Annual Arizona Biotech Day Announced for October 23rd 2008 2First Annual Arizona Biotech Day Announced for October 23rd 2008 3AMDL, Inc. to Present at Maxim Group Growth Conference October 7, 2008 2AMDL, Inc. to Present at Maxim Group Growth Conference October 7, 2008 3Micromet Closes $40 Million Private Equity Placement 2Micromet Closes $40 Million Private Equity Placement 3Micromet Closes $40 Million Private Equity Placement 4
... 75 x ... recommended for immunohistochemistry of paraffin-embedded sections, ... at one end, markings ... normal procedures, precleaned, ...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Donor feline serum and plasma...
Request Info...
Biology Products: