Navigation Links
New technique enables high-sensitivity view of cellular functions
Date:11/1/2012

Troy, N.Y. Researchers at Rensselaer Polytechnic Institute have developed an ultrasensitive method for detecting sugar molecules or glycans coming from living organisms, a breakthrough that will make possible a more detailed understanding of cellular functions than either genetic or proteomic (the study of proteins) information can provide. The researchers hope the new technique will revolutionize the study of glycans, which has been hampered by an inability to easily detect and identify minute quantities of these molecules.

"The glycome is richer in information than the genome or the proteome. A cancer cell, for example, might have the same genome as a non-cancer cell, but it produces different sugars," said Robert Linhardt, the Ann and John H. Broadbent Jr. '59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer, and an author of the study. "Until now, the stumbling block in glycomics has been rapid and sensitive determination of the glycans present in a biological sample, and up to now we were very limited by how much we could detect. With this technique that we've developed, Glyco-qPCR, we can detect a very small number of molecules and that should accelerate the growth of the field."

The new technique is discussed in a paper titled "Signal Amplification by Glyco-qPCR for Ultrasensitive Detection of Carbohydrates: Applications in Glycobiology," which was published in the Oct. 16 online edition of Angewandte Chemie International. Linhardt and Jonathan Dordick, director of the Rensselaer Center for Biotechnology and Interdisciplinary Studies (CBIS), vice president for research, and the Howard P. Isermann '42 Professor of Chemical and Biological Engineering, were joined in the research by Seok Joon Kwon, Kyung Bok Lee, Kemal Solakyildirim, Sayaka Masuko, Mellisa Ly, Fuming Zhang, and Lingyn Li.

Linhardt used the analogy of a house to explain the importance of glycans in biology and the pr
'/>"/>

Contact: Mary Martialay
martim12@rpi.edu
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New synthetic biology technique boosts microbial production of diesel fuel
2. New genetic bar code technique establishes ability to derive DNA information from RNA
3. Early detection techniques offer hope for improved outcomes in lung cancer patients
4. Scientists develop new technique that could improve heart attack prediction
5. New rearing system may aid sterile insect technique against mosquitoes
6. Its a trap! New laboratory technique captures microRNA targets
7. New screening technique yields elusive compounds to block immune-regulating enzyme
8. New stem cell technique promises abundance of key heart cells
9. Evaluation of microscopy techniques may help scientists to better understand ancient plants
10. New technique allows simulation of noncrystalline materials
11. Transgenic technique to eliminate a specific neural circuit of the brain in primates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 31, 2015   Guidepoint , a leading global ... Post-Surgical Pain Management TRACKER, part of the Guidepoint ... in the medical device and therapeutics markets. The Post-Surgical ... treatment volumes, market share, and adoption rates across three ... joint surgery. The Post-Surgical Pain Management TRACKER ...
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ... Iris Recognition Market 2015-2019" report to their offering. ... market to grow at a CAGR of 23.5 percent ... the present scenario and the growth prospects of the ... calculate the market size, the report considers the revenue ...
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... Imagine a cellphone battery that stayed charged for more ... dream battery could be closer to reality thanks to Northwestern ... an electrode for lithium-ion batteries -- rechargeable batteries such as ... batteries to hold a charge up to 10 times greater ...
... -- Feeding older mice a lower glycemic index (GI) ... age-related, sight-threatening retinal lesions, according to a new study ... the Jean Mayer USDA Human Nutrition Research Center on ... researchers studied middle-aged and older mice that consumed either ...
... N.C. In a finding that confirms what many ... younger women who undergo hysterectomies face a nearly two-fold ... published in the December issue of the journal ... track over time the actual hormonal impact of woman ...
Cached Biology News:Better batteries 2Better batteries 3AMD-like lesions delayed in mice fed lower glycemic index diet 2AMD-like lesions delayed in mice fed lower glycemic index diet 3Hysterectomy increases risk for earlier menopause among younger women 2
(Date:4/17/2015)... April 17, 2015 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: ... company that develops and commercializes proprietary technologies and ... that it has received approval from the TSX ... outstanding common share purchase warrants ("the Warrants") of ... the Company,s May 2013 private placement financing. ...
(Date:4/17/2015)... TX (PRWEB) April 17, 2015 ... and proteomics technologies, announced today that it is ... system, an innovative multiplex PCR based targeted sequencing ... resolution sequence analysis, that enables accurate detection of ... Relay-PCR™ and Omega-Primer™ technologies. The company will collaborate ...
(Date:4/16/2015)... Mass. (PRWEB) April 16, 2015 ... smart data solutions driven by Semantic Web technology, ... of specialist information and services for the academic ... announced that its joint solution ‘Smart Data Lake ... a finalist for the 2015 Bio-IT ‘Best of ...
(Date:4/16/2015)... 2015  Schulman Associates IRB, Inc., the industry-leading central ... long-term lease on Laboratory Drive in the heart of ... The location will house review board and service staff, ... reviews and customer service to clients. ... in the deal, while Capital Associates Management, LLC represented ...
Breaking Biology Technology:SQI Diagnostics to Extend Warrant Expiry 2SQI Diagnostics to Extend Warrant Expiry 3LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Schulman IRB to Open Office in Research Triangle Park, N.C. 2
... April 22 Transgenomic Inc. (OTC,Bulletin Board: TBIO) announces the following Webcast:, ... Conference Call, ... Eastern, Where: http://www.transgenomic.com/events.asp?id=6 , How: ... web at the ...
... American Oriental,Bioengineering, Inc. (NYSE: AOB ), a leading ... China, today,announced that it plans to release first quarter ... market opens., The Company will hold a conference ... to,discuss its fiscal first quarter 2008 results. Listeners may ...
... - Strong Sales Growth Across All Product Lines ... Sales Growth ... IRVINE, Calif., April 22 Edwards Lifesciences,Corporation (NYSE: EW ... disease, today reported net income for the,quarter ended March 31, 2008 ...
Cached Biology Technology:American Oriental Bioengineering to Report First Quarter 2008 Financial Results 2Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 2Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 3Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 4Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 5Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 6Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 7Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 8Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 9Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 10Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 11Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 12Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 13Edwards Lifesciences Reports Strong First Quarter Results and Raises 2008 Guidance 14
... effect inhibition assays, also known as CPE and ... supernatents; serum from PK studies and delivery formulations. ... as the quantity of interferon required per milliliter ... by 50%. All standards used in ...
HyPro 100, includes 5 x HyPro20 and HyPro Cabinet. 100 slide capacity. Active vibration system, slide rack and humidity chamber. Ideal for microarray and in situ hybridization....
... are cytopathic effect inhibition assays, also known as ... tissue culture supernatents; serum from PK studies and ... is defined as the quantity of interferon required ... viral infection by 50%. All standards ...
Request Info...
Biology Products: