Navigation Links
New technique could dramatically lower costs of DNA sequencing
Date:12/12/2007

CHAMPAIGN, Ill. Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip. The technique could lead to a device that would read human genomes quickly and affordably.

Being able to sequence a human genome for $1,000 or less (which is the price most insurance companies are willing to pay) could open a new era in personal medicine, making it possible to precisely diagnose the cause of many diseases and tailor drugs and treatment procedures to the genetic make-up of an individual.

Despite the tremendous interest in using nanopores for sequencing DNA, it was unclear how, exactly, nanopores could be used to read the DNA sequence, said U. of I. physics professor Aleksei Aksimentiev. We now describe one such method.

Aksimentiev and collaborators describe the method in a paper accepted for publication in the journal Nano Letters, and posted on the journals Web site.

Through molecular dynamics simulations, we demonstrate that back-and-forth motion of a DNA molecule in a nanopore capacitor 1 nanometer in diameter produces an electrostatic fingerprint that can be used to read the genetic sequence, said Aksimentiev, who also is a researcher at the Beckman Institute.

In the researchers simulations, performed at the universitys National Center for Supercomputing Applications, the nanopore capacitor consists of two conducting layers of doped silicon, separated by an insulating layer of silicon dioxide.

As DNA passes through the nanopore, the molecules electric field induces sequence-specific electrostatic potentials that can be detected at the top and bottom layers of the capacitor membrane.

A semiconductor device capable of reading the electrostatic potentials and decoding the genetic sequence is within the grasp of current technology, Aksimentiev said.

Nanometer pores in electronic membranes
'/>"/>

Contact: James E. Kloeppel
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert

Page: 1 2

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
7. New X-ray technique targets terrorists and tumors
8. Technique controls nanoparticle size, makes large numbers
9. Newly created cancer stem cells could aid breast cancer research
10. Obesity and lack of exercise could enhance the risk of pancreatic cancer
11. Finding that 1-in-a-billion that could lead to disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... The most comprehensive study to date of the ... to more effective vaccine strategies and reveals surprising ... new results could alter public health strategies to ... worldwide each year. , Genomic analysis of 343 ... from around the world collected over the last ...
(Date:4/23/2014)... technique used to read quickly. It involves visual ... words and/ or sentences. Similarly to humans, biological ... "read" genetic information. Genes that need to be ... the encoding message, the easier it will be ... Gulbenkian de Cincia (IGC, Portugal) and Centre for ...
(Date:4/22/2014)... lead a five-year, $3 million study to determine whether ... transport of dissolved organic matter (DOM) through the Connecticut ... chemical composition and water quality of the watershed and ... Science Foundation,s MacroSystems Biology program, researchers will collect data ... in Canada and runs through five U.S. states, before ...
Breaking Biology News(10 mins):Impact of whooping cough vaccination revealed 2Cell division speed influences gene architecture 2Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3
... of Illinois researchers identified the top pathogens, pests and ... Food Security. Soybean aphid, soybean rust, soybean cyst nematode, ... red leaf blotch, were featured as some of the ... and in the future. "Enormous potential exists to ...
... 2011) The remoteness and resource limitations of spaceflight ... solution is ultrasound. Scientists with the National ... expand the use of ultrasound during spaceflight and on ... include techniques that streamline training and help remote experts ...
... For most people, listening to the ocean means ... a sandy beach. But for researchers studying everything ... mapping to guiding robots trying to repair leaking undersea ... side underwater can reveal volumes of valuable ...
Cached Biology News:New and old threats to soybean production 2Space research gives birth to new ultrasound tools for health care in orbit, on Earth 2Space research gives birth to new ultrasound tools for health care in orbit, on Earth 3Space research gives birth to new ultrasound tools for health care in orbit, on Earth 4'Orca ears' inspire Stanford researchers to develop ultrasensitive undersea microphone 2'Orca ears' inspire Stanford researchers to develop ultrasensitive undersea microphone 3'Orca ears' inspire Stanford researchers to develop ultrasensitive undersea microphone 4
(Date:1/15/2014)... Look inside the new Preferred Solutions® ... lab, from fluid handling to instruments to supplies. Many ... you order. , Preferred Solutions features a full ... L/S® model for precise flow control and dispensing to ...
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... 2014 This webinar will focus on ... safety assessment in biosimilars. , Regulatory frameworks are evolving ... development, however the complex nature of biopharmaceuticals makes the ... efficacy extremely challenging. Based on the specific aspects of ...
(Date:1/15/2014)... Houston, TX (PRWEB) January 15, 2014 ... Alzheimer’s disease, and about 1 in 3 seniors will ... ( source ). These jaw-dropping figures have shocked many ... function and, hopefully, help prevent these tragic age-related cognitive ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2
... America,s Heartland, the,weekly public television series that celebrates the ... season this fall. Twenty-two new half-hour segments will ... middle of the third season,America,s Heartland will have profiled ... 50 states. The program is made possible with ...
... PALO ALTO, Calif., Oct. 3 Alexza,Pharmaceuticals, Inc. ... corporate,presentation will be webcast live during the 4th ... at 4:30 p.m. Eastern Time. The presentation,will be ... may be accessed,under the Investor Relations tab at ...
... to 45%, GURGAON, India, Oct. 3 Ranbaxy ... the,signing of Definitive Agreements, providing for an increase in ... at a price of Rs. 160 per share,aggregating to ... shares from the existing Promoters (b) Preferential Offer ...
Cached Biology Technology:America's Heartland Launches Third Season Highlighting Contributions of American Farmers and Ranchers 2The 4th Annual BIO Investor Forum to Webcast Alexza's Corporate Presentation 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 3
... SPD101B is a no-frills, basic SpeedVac concentrator ... economically priced, this unit still features a ... digitial display of time and heat. It ... and accepts a wide variety of different ...
... to have active, real-time sample temperature monitoring. ... the worlds first, fully modular SpeedVac System. ... together to form an integrated unit or ... also the first SpeedVac to have sample ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
... Acid Resistant SpeedVac Model SPD131DDA , ... , The SPD131DDA is designed to handle the ... a new slim design, digital display, dual independent ... TEFLON coated chamber and vapor pathway. , , ...
Biology Products: