Navigation Links
New technique allows targeted inactivation of genes in research model
Date:5/27/2008

WORCESTER, Mass. Researchers at the University of Massachusetts Medical School (UMMS) report today on a new technique that improves the ability of scientists to target individual genes for inactivationa technique with broad potential implications for both basic science research and human disease. Two scientific teams at UMMS, one led by Scot A. Wolfe, PhD, an assistant professor in the Program in Gene Function & Expression and the Department of Biochemistry & Molecular Pharmacology, and the other by Nathan D. Lawson, PhD, an associate professor in the Program in Gene Function and Expression and the Program in Molecular Medicine, working with a small fishthe zebrafishcommonly used as a model organism in biomedical research, developed a method to create and deliver a tailor-made restriction enzyme that inactivates a specific gene in a zebrafish embryo.

The paper, Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases appears as an Advance Online Publication of the journal Nature Biotechnology (25 May, 2008; http://dx.doi.org/10.1038/nbt1398 ), and was supported by grants from the National Heart, Lung and Blood Institute and the National Institute of General Medical Sciences.

The best way to figure out what a gene does in an organism is to replace it with a non-functional version, breed the individual, and then look at the offspring to see whats wrong with them, said Laurie Tompkins, Ph.D., who oversees genetic mechanisms grants at the National Institute of General Medical Sciences, The problem is that its hard to swap in non-functional genes that are inherited by the offspring. These investigators have devised a way to do this, which will enable many scientists to answer questions that were previously out of reach.

We believe that this work will fundamentally change how researchers make knockoutsresearch organisms in which one or more genes have been genetically engineered to be turned offin many model organisms
'/>"/>

Contact: Office of Public Affairs
public.affairs@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
7. New X-ray technique targets terrorists and tumors
8. Technique controls nanoparticle size, makes large numbers
9. New technique could dramatically lower costs of DNA sequencing
10. New techniques create butanol
11. New radar satellite technique sheds light on ocean current dynamics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... By tracing nearly 3,000 genes to the earliest ... Florida scientists have created an extensive "Tree of ... next-generation DNA sequencing. , Among the study,s ... to small moths than to large ones, which ... The study also found that some insects once ...
(Date:7/31/2014)... many of the roughly 156,000 gas stations across ... in parts of underground gas storage tankscorrosion that ... groundwater, a source of drinking water. In recent ... many rapidly corroding gas storage tank components such ... with use of gasoline-ethanol blends and the presence ...
(Date:7/31/2014)... Neb., July 31, 2014 -- Do people make a ... mothers raise them that way? Is it a matter ... Nebraska-Lincoln and a colleague from Rice University say that ... some people lean left while others lean right. , ... and deep-seated psychology are at the core of political ...
Breaking Biology News(10 mins):UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3NIST corrosion lab tests suggest need for underground gas tank retrofits 2Scientists find growing consensus: Political attitudes derive from body and mind 2
... , SAN DIEGO, Dec. 10 ... of an existing building (Keen Hall), including a previously unused ... for the University of California, Riverside. Ken Kornberg, president ... project element was to ensure that although the facility was ...
... WASHINGTON, Dec. 10, 2009 Arup K. SenGupta, Ph.D., ... Lehigh University in Bethlehem, Pa., has been chosen to ... administered by the American Chemical Society, is given to ... improve public health through their work in the chemical ...
... the University of California, Riverside will receive more than $1 ... Antenna Research Center ( PARC ), to be headquartered at ... to better understand natural photosynthetic systems and design more durable ... cells during the past 15 years has failed to appreciably ...
Cached Biology News:Kornberg Associates | Architects Completes UC Riverside Stem Cell Core Facility Project 2Copying mother nature's designs 2
(Date:7/31/2014)... the entire body to visualize long-range connections between cells ... long-time dream of biologists. A study published by ... Cell has now made that dream a reality, ... human tissue biopsies transparent, while keeping the cellular structures ... for a better understanding of brain-body interactions, more accurate ...
(Date:7/31/2014)... 2014 The SNIS Foundation recognized its ... fund a translational research project.  The first award ... was presented at the Society of NeuroInterventional Surgery ... Colorado Springs, CO. ... neurovascular conditions, SNIS formed the SNIS Foundation, in ...
(Date:7/31/2014)... Graphite Metallizing Corporation announces GRAPHALLOY® ... bearings are uniquely suited to prevent loss of lubrication ... the high temperatures . , Recently, a manufacturer ... engineers at Graphite Metallizing to overcome problems with movement ... operation, pans containing blocks of powder mixture are loaded ...
(Date:7/31/2014)... -- Research and Markets has announced the ... report to their offering. ... the genetic material or genomes of an organism. It ... discovery and development of diagnostic and therapeutic solutions for ... is supported by three major product segments: Instruments, Consumables, ...
Breaking Biology Technology:See-through organs and bodies will accelerate biomedical discoveries 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 3Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... Oxygen Biotherapeutics, Inc. (OTC Bulletin Board: ... development and commercial supply agreement with Hospira ... business unit to manufacture clinical-grade Oxycyte(R). Oxycyte ... carrier. Oxycyte will be manufactured at Hospira,s ...
... on the 1918 Spanish Influenza Strain Protected Mice and ... Bird FluROCKVILLE, Md., April 14 ... NVAX ) today reported preclinical study results ... based on the 1918 Spanish influenza strain protected against ...
... - BioMS Medical Corp. (TSX: MS), a leading developer ... that the independent Data Safety Monitoring Board (DSMB) for ... dirucotide in patients with secondary progressive MS has completed ... as per the protocol. , This was the fourth ...
Cached Biology Technology:Oxygen Biotherapeutics, Inc. Signs Supply Agreement for Clinical-Grade Oxycyte for Clinical Trials and Future Needs 2NOVAVAX Announces Publication of a Preclinical Study Demonstrating that a Virus-like Particle Vaccine Provided Protection Against Highly Pathogenic H1N1 and H5N1 Influenza Strains 2NOVAVAX Announces Publication of a Preclinical Study Demonstrating that a Virus-like Particle Vaccine Provided Protection Against Highly Pathogenic H1N1 and H5N1 Influenza Strains 3NOVAVAX Announces Publication of a Preclinical Study Demonstrating that a Virus-like Particle Vaccine Provided Protection Against Highly Pathogenic H1N1 and H5N1 Influenza Strains 4NOVAVAX Announces Publication of a Preclinical Study Demonstrating that a Virus-like Particle Vaccine Provided Protection Against Highly Pathogenic H1N1 and H5N1 Influenza Strains 5BioMS Medical's phase III U.S. multiple sclerosis trial receives positive safety review from Data Safety Monitoring Board 2
...
The Holten Horizontal series of laminar airflow work benches offers comfort and ease of use....
... Rotor designed for use in the ... Centra-MP4/MP4R*. A translucent lid is included ... rotor design provides excellent chemical resistance ... Polypropylene rotors are fully compatible with ...
Medium bottle for hybridization 250 x 35mm...
Biology Products: