Navigation Links
New substance may allow successful transplantation of 'marginal' livers
Date:6/1/2011

New research raises the possibility that the critically short supply of livers for organ donation could be expanded by treating so-called "marginal" livers with a substance that protects them from damage after being connected to recipients' blood supplies. The report appears in ACS' journal Molecular Pharmaceutics.

Ram Mahato and colleagues note that the need for liver transplants has grown over the years, though the number of available livers has not. Currently, more than 16,000 people are waiting for a liver in the U.S., but less than 7,000 liver transplants were performed during the entire year of 2010. This shortage has led organ transplant teams to consider using marginal, or damaged, livers, such as those with cholestasis a build-up of bile. But transplanting a damaged liver has risks, including a higher risk that the organ will fail. To overcome this challenge, the researchers utilized a hedgehog-signaling inhibitor to increase the odds of a successful liver transplant.

They found that a compound called cyclopamine prevented further injury to cholestatic livers after the blood supply was cut off then returned a situation similar to what transplanted livers undergo. The research was performed in rats, which are stand-ins for humans in the laboratory. It provided "convincing evidence" that cyclopamine may protect cholestatic livers from additional damage after a transplant procedure and improve clinical outcomes for the patients.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. UI researchers find potentially toxic substance present in Chicago air
2. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
3. Airway cells use tasting mechanism to detect and clear harmful substances
4. Can an over-the-counter vitamin-like substance slow the progression of Parkinsons disease?
5. Heat forms potentially harmful substance in high-fructose corn syrup
6. Exposure to alkaline substances can result in damaged teeth
7. Pathological gambling may be successfully treated with medications for substance addiction
8. Smokeless tobacco called moist snuff is contaminated with harmful substances
9. Invasive fish and mussels team up to transfer toxic substances into Great Lakes walleyes
10. Healing haze: Substances in smoke left over from forest fires speed plant growth
11. Substance in breast milk kills cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... WINSTON-SALEM, N.C. , March 12, 2015 ... afternoon at Brenner Children,s Hospital, part of Wake Forest ... an outreach initiative for the 2015 ACC Men,s Basketball ... taking pictures with them and getting their autographs. ... Wake Forest Baptist. It is the only children,s hospital ...
(Date:3/11/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ) has ... by Product, Application & By Geography - Global Forecast ... , This report predicts that the access ... 2020, with an estimated CAGR of 10.6%. ... such as contact cards & readers, contactless cards & ...
(Date:3/10/2015)... Colo. , March 10, 2015 ... Flight "Personalized Medicine in Human Space ... and Thomas J. Goodwin , Ph.D. was recently ... of the past two years. Specifically, "Personalized ... most downloaded scientific papers published in 2013 and 2014 ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2
... when cooks in France and elsewhere will be slipping bits ... for a luxurious flavor, scientists are revealing the secrets that ... Their study, which could lead to better ways to determine ... ACS, Journal of Proteome Research . Mark ...
... The astonishing success of the alien invasive harlequin ladybird in ... to investigate a key ecological theory the Enemy Release ... new alien species arrives into a country or region it ... Writing in the latest issue of the ...
... of how cancer cells evolve could help scientists design ... , Researchers at Fred Hutchinson Cancer Research Center studying ... than resulting from a steady accumulation of small genetic ... to undergo large, drastic mutations. This insight could help ...
Cached Biology News:Scientists unearth secrets of Périgord truffles, the culinary 'black diamond' 2Harlequin ladybirds escape enemies while native species succumb 2New insights into cancer evolution help define screening window of opportunity 2New insights into cancer evolution help define screening window of opportunity 3
(Date:3/25/2015)... 25, 2015 Laboratory workers can ... and Analytical Balances to get best-performing features while ... weighing balances from the trusted brand include: , ... increase your efficiency by providing a large weighing ... Weighing modes include parts counting, percent weighing, checkweighing, ...
(Date:3/25/2015)... CAMBRIDGE, Mass. and REYKJAVIK, Iceland ... provides comprehensive capabilities for using the genome to create better ... publication of the largest studies of whole-genome data yet undertaken. ... Nature Genetics – are built around ... authored by a team of deCODE scientists led by ...
(Date:3/25/2015)... 2015  Point-of-Care Partners, a leading health information ... launched the ePrescribing State Law Capsule -- a ... regulatory requirements in all 50 states and DC.  ... to change rapidly, so we have evolved our ... ultimately patients, need," said Tony Schueth , ...
(Date:3/25/2015)... Having added two International locations in ... 2014, ITRA Global proudly announced recently the organization’s expansion ... Alliance, based in the United States, is one of ... of commercial real estate. , Saltwood International ... that exclusively advises occupiers of office space, ensuring that ...
Breaking Biology Technology:New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Point-of-Care Partners Launches the ePrescribing State Law Capsule 2International Organization Expands its Global Reach to Warsaw, Poland 2
... group of Master of Science in Biotechnology students ... University of Wisconsin-Madison this weekend. For the past two years ... from last year's pilot class of 10, to get deeper ... ,"There is an interdependence in the program: business, science and ...
... to use a $75,000 grant to make the financial relationships ... available online. , ,The grant came from the Joyce ... policy. , ,All the information is already available, but ... is charged with keeping track of the financial relationships of ...
... been written, said, and even adjudicated about peer-to-peer music sharing ... service promising to legitimize song sharing. Yet Mercora ... million people who have downloaded the software since its quiet ... IM Radio the IM stands for Individual Modulation ...
Cached Biology Technology:New UW master's program ramps up to fill demand for biotech skills 2New UW master's program ramps up to fill demand for biotech skills 3Ethics Board to put financial disclosures online with new grant 2Mercora gets music sharing right 2Mercora gets music sharing right 3
...
...
Physical Form: powder Color: white Removes FLAG peptide from N-terminal and Met-N-terminal fusion proteins. Supplied with optimized enterokinase buffer....
... The Universal Vacuum System UVS400 is ... system. The UVS400 combines a refrigerated vapor ... in a single integrated unit. The easy-to-use, ... recovered solvent into single jar for easy ...
Biology Products: