Navigation Links
New substance may allow successful transplantation of 'marginal' livers
Date:6/1/2011

New research raises the possibility that the critically short supply of livers for organ donation could be expanded by treating so-called "marginal" livers with a substance that protects them from damage after being connected to recipients' blood supplies. The report appears in ACS' journal Molecular Pharmaceutics.

Ram Mahato and colleagues note that the need for liver transplants has grown over the years, though the number of available livers has not. Currently, more than 16,000 people are waiting for a liver in the U.S., but less than 7,000 liver transplants were performed during the entire year of 2010. This shortage has led organ transplant teams to consider using marginal, or damaged, livers, such as those with cholestasis a build-up of bile. But transplanting a damaged liver has risks, including a higher risk that the organ will fail. To overcome this challenge, the researchers utilized a hedgehog-signaling inhibitor to increase the odds of a successful liver transplant.

They found that a compound called cyclopamine prevented further injury to cholestatic livers after the blood supply was cut off then returned a situation similar to what transplanted livers undergo. The research was performed in rats, which are stand-ins for humans in the laboratory. It provided "convincing evidence" that cyclopamine may protect cholestatic livers from additional damage after a transplant procedure and improve clinical outcomes for the patients.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. UI researchers find potentially toxic substance present in Chicago air
2. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
3. Airway cells use tasting mechanism to detect and clear harmful substances
4. Can an over-the-counter vitamin-like substance slow the progression of Parkinsons disease?
5. Heat forms potentially harmful substance in high-fructose corn syrup
6. Exposure to alkaline substances can result in damaged teeth
7. Pathological gambling may be successfully treated with medications for substance addiction
8. Smokeless tobacco called moist snuff is contaminated with harmful substances
9. Invasive fish and mussels team up to transfer toxic substances into Great Lakes walleyes
10. Healing haze: Substances in smoke left over from forest fires speed plant growth
11. Substance in breast milk kills cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... 27. Februar 2017  EyeLock LLC, ein marktführendes Unternehmen ... erstklassige biometrische Lösung zur Iris-Erkennung auf der ... LTE auf dem Mobile World Congress 2017 ... in Halle 3, Stand 3E10, vorstellen. ... Qualcomm Haven™ – eine Kombination aus Hardware, ...
(Date:2/24/2017)...  EyeLock LLC, a leader of iris-based identity ... biometric solution on the latest Qualcomm® Snapdragon™ 835 ... World Congress 2017 (February 27 – March ... 3, Stand 3E10. The Snapdragon ... platform—a combination of hardware, software and biometrics ...
(Date:2/21/2017)... Der weltweite Biobanking-Sektor wird bis zum Jahr 2018 ... mehr als 50 Vertretern aus verschiedenen Branchen wurde aber klar, ... Prognose zu realisieren. ... Zu den Schwierigkeiten für Biobanking-Profis ... die Biobank, die Implementierung Zeit sparender Technologien, ein besseres ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... ... Franz Inc ., the leading supplier of Semantic Graph Database technology, ... by Bloor Research in its recent Graph Database Market Update report. ... Gruff, it was rated as the easiest product to use.” – Bloor Research , ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... time members of the Modular Building Institute (MBI), an international modular trade organization, ... the permanent modular category for the Pagliuca Life Lab at Harvard University. The ...
(Date:3/28/2017)... , Belgium , March 28, 2017 ... VolitionRx Limited (NYSE MKT: VNRX), today announced the engagement of ... DVD Associates, LLC, as a strategic consultant. Dr. Vollmer ... identifying and securing non-dilutive funding in the State ... United States . Dr. Vollmer Dahlke has ...
(Date:3/28/2017)... SACRAMENTO, Calif. , March 28, 2017 /PRNewswire/ ... Officer of international life sciences corporation Anpac ... company set a new, international record, processing and ... proprietary, "Cancer Differentiation Analysis" (CDA) liquid ... in World Nobel Prize Laureate Summit publications, Anpac ...
Breaking Biology Technology: