Navigation Links
New substance effectively combats multi-resistant bacteria
Date:10/29/2013

MULTI-RESISTANCE: In Europe alone, more than 25,000 people die each year from infections caused by multi-resistant bacteria. Researchers from University of Copenhagen have now developed and characterized a substance that quickly and effectively kills the virulent bacteria. The substance employs a multifunctional mechanism that reduces the risk of antibiotic resistance. The findings have recently been published in the scientific journal Chemistry & Biology.

Since WWII, antibiotics have made it possible to cure lethal bacterial infections. However, in recent years the efficacy of antibiotics has been drastically reduced due to increasing bacterial resistance. Today, bacteria resistant to nearly all known antibiotics are prevalent in many parts of the world.

"We have succeeded in preparing and characterizing a very stable substance that kills multi-resistant bacteria extremely quickly and effectively. The most interesting aspect is that the bacteria are attacked using a multifunctional mechanism that drastically reduces the risk of resistance development compared with traditional antibiotics," says Rasmus Jahnsen.

Jahnsen conducted the research into the development of substances against multi-resistant bacteria at the Department of Drug Design and Pharmacology, University of Copenhagen.

The recently developed substance is called HDM-4, which stands for Host Defence Peptidomimetic 4. The findings are the result of collaboration between University of Copenhagen and the University of British Columbia in Canada.

Boosts the innate immune response

For a number of years, a group of researchers led by Associate Professor Henrik Franzyk at the Faculty of Health and Medical Sciences have worked on the optimization of a unique class of antibacterial substances. All plants, animals and humans produce the important antimicrobial peptides that form part of the innate immune system the body's first line of defence against bacterial attack.

"The killing mechanism involves destabilising the bacterial membrane and binding onto the bacteria's DNA, which in both cases results in the death of the bacteria. We have also shown that the substance can activate the human body's own immune cells, strengthening its defence against bacteria during infection," says Rasmus Jahnsen.

Pharmaceutical industry lacks interest in antibiotics

The researchers have tested the new substance on bacteria-infected tissue and the results show that it possesses several characteristics that make it highly attractive in connection with the possible development of new antibiotics.

"It's the first step to developing a new drug. We hope that in collaboration with partners we can conduct a series of tests in the near future to show that the substance can actually combat an infection in a mammal. If we achieve the same results in animals, we will have a potential sensation on our hands," adds Rasmus Jahnsen.

Jahnsen believes the pharmaceutical industry needs to become more actively involved.

"Only a tiny fraction of the pharmaceutical research is devoted to development of new antibiotics partly because research into cancer and chronic diseases such as diabetes and cardiovascular diseases are seen as better long-term investments. This leaves us in the extremely unfortunate situation where infectious diseases once again pose extremely serious threats to human health as the efficacy of medical drugs continues to be undermined by bacterial resistance. It is therefore important to conduct more research into new antibiotics," concludes Rasmus Jahnsen.


'/>"/>

Contact: Rasmus Jahnsen
rasmus.jahnsen@sund.ku.dk
45-26-27-88-04
University of Copenhagen
Source:Eurekalert

Related biology news :

1. Using cell phones to detect harmful airborne substances
2. On the safe side: Contact-free analysis of chemical substances
3. Hopes that new substance will induce cancer cell suicide
4. Colorful wall hangings contain toxic substances
5. Scientists sniff out the substances behind the aroma in the king of fruits
6. Substances from African medicinal plants could help stop tumor growth
7. Vinyl flooring linked to potentially harmful substances at schools and daycare centers
8. Ecosystems cope with stress more effectively the greater the biodiversity
9. Food industrys high-quality co-streams used effectively as raw material for new products
10. Immunohistochemistry effectively detects ALK rearrangement
11. Largest therapy trial worldwide: Psychotherapy treats anorexia effectively
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... -- Aware, Inc. (NASDAQ: AWRE ), a leading supplier of ... quarter and year ended December 31, 2015.  ... 2015 was $6.9 million, an increase of 61% compared to $4.3 ... fourth quarter of 2015 was $2.6 million compared to $0.2 million ... --> Higher revenue and operating income in the ...
(Date:2/3/2016)... 4, 2016 --> --> ... M (105.0), up 1,187% compared with fourth quarter of 2014. ... 517.6 M (loss: 30.0). Earnings per share increased to SEK ... 537.4 M (neg: 74.7). , --> ... to SEK 2,900.5 M (233.6), up 1,142% compared with 2014. ...
(Date:2/2/2016)... This BCC Research report provides a ... the recent advances in high throughput ‘omic platforms ... forward. Includes forecast through 2019. Use ... opportunities that exist in the bioinformatic market. Analyze ... well as IT and bioinformatics service providers. Analyze ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... Inc. (NASDAQ: NBIX ) today announced its financial results for ... --> --> For the fourth quarter of ... $0.34 loss per share, compared to a net loss of $19.4 ... 2014. For the year ended December 31, 2015, the Company reported ... as compared to a net loss of $60.5 million, or $0.81 ...
(Date:2/11/2016)... International, a not-for-profit organization focused on the ethics and governance ... to patients around the world, today announced that the editors ... the Good Pharma Scorecard an ,Editors, Pick, ... of BMJ Open ,s ,Most Popular Articles, which includes ... read. Ed Sucksmith , assistant editor of ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... information focused on the development and manufacture of biopharmaceuticals and therapeutics, announces ... of the 2016 BioProcess International Awards – Recognizing Excellence in the People, ...
(Date:2/11/2016)... --  BioInformant announces the February 2016 release of ... Tools, and Technologies – Market Size, Segments, Trends, and ... The first and only market research ... has more than a decade of historical information on ... cell type. This powerful 175 page global strategic report ...
Breaking Biology Technology: