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New substance effectively combats multi-resistant bacteria
Date:10/29/2013

MULTI-RESISTANCE: In Europe alone, more than 25,000 people die each year from infections caused by multi-resistant bacteria. Researchers from University of Copenhagen have now developed and characterized a substance that quickly and effectively kills the virulent bacteria. The substance employs a multifunctional mechanism that reduces the risk of antibiotic resistance. The findings have recently been published in the scientific journal Chemistry & Biology.

Since WWII, antibiotics have made it possible to cure lethal bacterial infections. However, in recent years the efficacy of antibiotics has been drastically reduced due to increasing bacterial resistance. Today, bacteria resistant to nearly all known antibiotics are prevalent in many parts of the world.

"We have succeeded in preparing and characterizing a very stable substance that kills multi-resistant bacteria extremely quickly and effectively. The most interesting aspect is that the bacteria are attacked using a multifunctional mechanism that drastically reduces the risk of resistance development compared with traditional antibiotics," says Rasmus Jahnsen.

Jahnsen conducted the research into the development of substances against multi-resistant bacteria at the Department of Drug Design and Pharmacology, University of Copenhagen.

The recently developed substance is called HDM-4, which stands for Host Defence Peptidomimetic 4. The findings are the result of collaboration between University of Copenhagen and the University of British Columbia in Canada.

Boosts the innate immune response

For a number of years, a group of researchers led by Associate Professor Henrik Franzyk at the Faculty of Health and Medical Sciences have worked on the optimization of a unique class of antibacterial substances. All plants, animals and humans produce the important antimicrobial peptides that form part of the innate immune system
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Contact: Rasmus Jahnsen
rasmus.jahnsen@sund.ku.dk
45-26-27-88-04
University of Copenhagen
Source:Eurekalert

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