Navigation Links
New study suggests possible genetic links between environmental toxins and multiple myeloma
Date:8/13/2009

North Hollywood, CA August 13, 2009 - The International Myeloma Foundation (IMF)supporting research and providing education, advocacy and support for myeloma patients, families, researchers and physicianstoday said newly published data may provide a possible genetic link between environmental toxins and bone disease in multiple myeloma. Myeloma, also called multiple myeloma, is a cancer of cells in the bone marrow that affect production of blood cells and can damage bone. Once considered a "rare disease of the elderly," it is increasingly being diagnosed in patients under 45 years old, including some of the early responders to the 9/11 World Trade Center site. Now a study published this week may help explain why.

The study from researchers with the IMF gene bank, Bank on a Cure, identified several changes in DNA sequences called SNPs (single nucleotide polymorphisms) that are associated with a risk of bone disease in myeloma. Further analyses showed that many of these DNA changes may be involved with the way the human body responds to certain environmental toxins, providing a possible link between myeloma and the environment. The findings were published in the latest issue of the journal Leukemia*.

Brian G.M. Durie, M.D., lead author of the study and Chairman of the IMF said: "This is a hypothesis-generating study. While the functional role of many SNPs is still uncertain, this study is supportive of the notion that genetic factors affecting toxin breakdown may be related to the development of myeloma. This gives us an important starting point for further studies."

The findings may help explain a widely reported study this week in the Journal of Occupational and Environmental Medicine, that found more cases of myeloma among younger responders to the 9/11 World Trade Center site than would normally be expected. The findings are also supportive of a study published earlier this year that suggests a link between certain pesticide exposures in agricultural workers and a precursor to multiple myeloma. Previous studies have also shown an increased risk for myeloma among firefighters, and the IMF has issued guidelines for firefighters for the prevention and treatment of this disease.

"Multiple myeloma is not a familiar cancer to patients or even to many doctors, but taken together, these studies say it should not be overlooked," said Susie Novis, President and Co-founder of the IMF. "While multiple myeloma cannot be cured, it can be treated with new, targeted therapies including REVLIMID, VELCADE and THALOMID. These studies tell us it is critically important for medical practitioners to know the possible risk factors for myeloma along with the early warning signs so they will be alerted to test for it."

Myeloma affects an estimated 750,000 people worldwide, and in industrialized countries it is being diagnosed in growing numbers and in increasingly younger people.


'/>"/>

Contact: Jennifer Anderson
212-918-4642
BioCom Partners
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... RALEIGH, N.C. and GENEVA, Dec, 20, 2016 ... performance biometric data sensor technology, and STMicroelectronics ... across the spectrum of electronics applications, announced today ... scalable development kit for biometric wearables that includes ... integrated with Valencell,s Benchmark™ biometric sensor ...
(Date:12/16/2016)... NEW YORK , Dec. 16, 2016 The global ... reach USD 12.14 billion by 2021 from USD 5.31 billion in ... ... market is mainly driven by technological advancements in medical devices, launch ... devices, rising preference for wireless connectivity among healthcare providers, and increasing ...
(Date:12/15/2016)... , Dec. 15, 2016 Advancements ... experience, health wellness and wellbeing (HWW), and ... in three new passenger vehicles begin to ... gesture recognition, heart beat monitoring, brain wave ... facial monitoring, and pulse detection. These will ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... , ... January 11, 2017 , ... ... society for optics and photonics , are commending the U.S. Congress and President ... signing Friday by the President of the American Innovation and Competitiveness Act (AICA). ...
(Date:1/11/2017)... ... January 11, 2017 , ... While the most acute effects ... becoming increasingly clear that the evolution and transmission dynamics of resistance gene dissemination ... study of clinical resistance, has vastly underestimated these reservoirs of resistance genes. ...
(Date:1/11/2017)... Philadelphia, PA (PRWEB) , ... January 11, 2017 ... ... seasoned entrepreneur can make all the difference when navigating the challenges young businesses ... can tap into the extensive expertise and experience of Geoff DiMasi, Founder and ...
(Date:1/11/2017)... ... January 11, 2017 , ... Advanced Polymer Monitoring ... team. Bernhard Bartylla will lead European initiatives for APMT’s product lines serving polymer ... and ARGEN to European manufacturers and researchers. Bernhard brings significant experience in our ...
Breaking Biology Technology: