Navigation Links
New study spotlights National Institutes of Health grant outcomes for clinical research
Date:7/25/2008

Although the need to translate basic science discoveries into the clinical arena is widely acknowledged, a new study by researchers at the Medical College of Wisconsin, in Milwaukee, and National Institutes of Health (NIH) identified reasons why clinical science grant applications receive less positive peer reviews than basic science grant applications to the NIH. The findings were published in the July issue of The American Journal of Medicine.

In collaboration with Michael R. Martin, Ph.D., and Teresa Lindqusit, MS, at NIH's Center for Scientific Review CSR), Dr. Theodore Kotchen, associate dean for clinical research and professor of medicine at the Medical College, studied 92,922 grant applications submitted to NIH between October 2000 and May 2004. Of that number, 67.5 percent were considered basic science applications and 32.5 percent were considered clinical applications. Dr. Kotchen is special advisor on clinical research to the NIH's CSR.

They found that investigators conducting clinical research were less likely to submit a continuing, competitive renewal grant application than investigators conducting basic research (20.0% vs. 28.3%). However, renewal applications generally receive more favorable reviews than new applications. The study concluded that approximately one-half of the observed differences in peer review outcomes for clinical versus basic research applications can be attributed to the lower rate of resubmission by clinical applicants.

Another reason for differences in review outcomes was related to applicants failing to adequately address human subject concerns in their applications. Human subject concerns, which the NIH defines as any potential or actual unacceptable risk or inadequate protection against risks to human subjects, were identified in 15% of clinical grant applications.

"Applications cited for having human subject concerns do not necessarily mean that the science is less meritori
'/>"/>

Contact: Toranj Marphetia
toranj@mcw.edu
414-456-4744
Medical College of Wisconsin
Source:Eurekalert

Page: 1 2

Related biology news :

1. Antimicrobial sutures reduce infections in brain shunt surgery, study finds
2. Plasma DNA level is a reliable marker of recurrent esophageal cancer, study finds
3. Landscape study may offer solutions for fire managers
4. Study: Typhoons bury tons of carbon in the oceans
5. Study shows parasites outweigh predators
6. Rutgers biologist to study worms in Amazon, glaciers
7. Study suggests past climate changes may have promoted the formation of new species in the Amazon
8. Sugar study is sweetener for stem cell science
9. MSU researcher uses grant to study little-known but largely useful microbes
10. Scripps study sets high economic value on threatened Mexican mangroves
11. Study reveals air pollution is causing widespread and serious impacts to ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Ill. Scientists have scoured cow rumens and termite ... cell walls for the production of next-generation biofuels, but ... in the human lower intestine, researchers report. , Their ... the National Academy of Sciences , is the first ... microbes in the human gut can digest fiber, breaking ...
(Date:9/23/2014)... essential in the development of animals and plants. The ... information be translated in a reliable manner to give ... French-flag model of stripe formation is a classic paradigm ... colours of the French flag, is caused by a ... middle or low concentrations of the morphogen a "blue", ...
(Date:9/23/2014)... Sept. 23, 2014 Research and Markets ... Market Forecast and Opportunities, 2019" report to their ... used for enhancing security and protection in private as ... . The country,s government is focusing on using biometric ... and other national IDs that are of crucial importance ...
Breaking Biology News(10 mins):Search for better biofuels microbes leads to the human gut 2Search for better biofuels microbes leads to the human gut 3Recreating the stripe patterns found in animals by engineering synthetic gene networks 2India Biometrics Market Forecast and Opportunities, 2019 2India Biometrics Market Forecast and Opportunities, 2019 3
... discovered the critical sequence of events by which insulin ... The study, appearing in the May 9 Journal of ... Institute of Child Health and Human Development and the ... , “This finding provides useful information for understanding disorders ...
... lipid membrane. The membrane is studded with many hundreds ... into and out of the cell. Such membrane proteins ... and make the nervous system work. Scientists at Stockholm ... membrane proteins in the enteric bacterium Escherichia coli. Their ...
... to migrate to the appropriate locations in the brain and ... in an intricate network. Growth cones, structures in the tips ... right direction, guided by a complex set of signals from ... axons to extend and grow in a particular direction; others ...
Cached Biology News:NIH Researchers Discover How Insulin Allows Entry of Glucose Into Cells 2Cerebral navigation: How do nerve fibers know what direction to grow in? 2
(Date:9/23/2014)... September 23, 2014 Proove Biosciences ... will be presenting research on the association between specific ... U.S. Psychiatric and Mental Health Congress’ 27th ... conference focuses on the theme of ‘Embracing Change.’ Mental ... a changing landscape. From the challenges presented by the ...
(Date:9/23/2014)... Manassas, VA (PRWEB) September 23, 2014 ... organization, is pleased to announce two important appointments to ... as Executive Vice President of Strategy and Technology and ... Director for the Standards Resource Center. Both roles are ... Raymond H. Cypess, President and CEO at ATCC described ...
(Date:9/23/2014)... and ANNAPOLIS JUNCTION, MD (PRWEB) September 23, 2014 ... research leader in personalized medicine, presented industry leading research ... misuse this past weekend at the American Academy ... The meeting took place in Phoenix, Arizona at the ... study on the linkage between gender and genetic predisposition ...
(Date:9/23/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced three ... to $5 million. The orders are all odour control projects ... continue to see new orders coming in," said Peter ... has climbed to over $11 million." About ... company that designs, manufactures and distributes a comprehensive line of ...
Breaking Biology Technology:Proove Biosciences Will Be Exhibiting New Genetic Research at the 27th Annual US Psych Congress Scientific Program 2Proove Biosciences Will Be Exhibiting New Genetic Research at the 27th Annual US Psych Congress Scientific Program 3ATCC Announces New Appointments to its Leadership Team 2ATCC Announces New Appointments to its Leadership Team 3Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 2Proove Biosciences Will Be Exhibiting I.M.P.L.O.R.E Study at the American Academy of Pain Management 25th Annual Meeting 3
... Pennsylvania and REHOVOT Israel, January 16, Rosetta ... today unveiled initial data relating to the ... which is,based on a simple blood draw, ... year. The,company,s scientists and collaborators have identified ...
... Varian, Inc.,(NasdaqGS: VARI) today announced a plan to ... to close certain facilities. , ... economic environment,we are taking proactive steps to reduce our ... while continuing to invest in new product,development and maintaining ...
... cells, vastly improved medical imaging techniques and lighter ... potential applications envisioned for organic electronics. ... Elisabetta Collini of University of Toronto,s Department of ... to new insights into the way molecules absorb ...
Cached Biology Technology:Rosetta Genomics and Collaborators Unveil Colon Cancer Screening Diagnostic; Identified Candidate MicroRNA Biomarkers in Serum 2Rosetta Genomics and Collaborators Unveil Colon Cancer Screening Diagnostic; Identified Candidate MicroRNA Biomarkers in Serum 3Rosetta Genomics and Collaborators Unveil Colon Cancer Screening Diagnostic; Identified Candidate MicroRNA Biomarkers in Serum 4Varian, Inc. Announces Cost Reduction Plan 2U of T chemistry discovery brings organic solar cells a step closer 2
... Tray (3 per pack), 1. ... blot processing.Automated staining of Coomassie Blue ... nucleic acid analysis.Prepares blots for high ... control of protocol, solution, volume, and ...
... 1 g. High quality kits ... preparation that give consistent and ... and tissues.Clean up samples from ... Accurately quantitate protein for first-dimension ...
GOAT ANTI CARICA PAPAYA PAPAIN...
PAb to Hu-IFN-Alpha/Beta R2 [(IFNAR2) CD118], Rabbit Serum, neutralizing Binds to but does not neutralize human interferon alpha/beta receptor...
Biology Products: