Navigation Links
New study shows that fetal cells to treat Parkinson's disease may not function long term
Date:4/6/2008

Neurons grafted into the brain of a patient with Parkinsons disease fourteen years ago have developed Lewy body pathology, the defining pathology for the disease, according to research by Jeffrey H. Kordower, PhD, and associates and published in the April 6 issue of Nature Medicine.

The finding suggest that Parkinsons disease is an ongoing process that can affect cells grafted into the brain in the same way the disease affects host dopamine neurons in the substantia nigra of the brain, according to Kordower, who is the lead author of the study and a neuroscientist at Rush University Medical Center.

These findings give us a bit of pause for the value of cell replacement strategy for Parkinsons disease, said Kordower. We still need to vigorously investigate this approach among the full armament of surgically-delivered Parkinsons disease therapies. While it is not clear to us whether the same fate would befall stem cell grafts, the next generation of cell replacement procedures, this study does suggest that grafted cells can be affected by the disease process.

The collaborative research study described in the article involves Rush, Mt. Sinai School of Medicine, New York, and the University of South Florida, Tampa, In it, individuals with Parkinsons disease received fetal cell transplants to reverse the loss in the brain of striatal dopamine.

The individual described in this article was a woman with a 22-year history of Parkinsons disease who underwent transplantation in 1993. After transplantation she experienced improvements in disease symptoms as measured by the Unified Parkinson Disease Rating Scale (UPDRS) and required substantially lower doses of antiparkinsonian medications. Her UPDRS scores remained improved into1997, but by 2004, she experienced progressive worsening of Parkinsons disease symptoms. She died in 2007 and her brain and that of two other patients in the study were comprehensively processed and analyzed. She h
'/>"/>

Contact: Mary Ann Schultz
mary_ann_schultz@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Yale study shows how rare genes have big impact on blood pressure
2. NASA launches airborne study of arctic atmosphere, air pollution
3. Some migratory birds cant find success in urban areas, study finds
4. Study finds concerns with biofuels
5. Veterinary college researcher studying brain tumors in people and animals
6. Statistics are insufficient for study of proteins signal system
7. Bear spray a viable alternative to guns for deterring bears, BYU study shows
8. Multi-institutional study identifies new form of inherited risk of cancer
9. Exposure to low levels of radon appears to reduce the risk of lung cancer, new study finds
10. Study finds pitching mound height affects throwing motion, injury risk
11. First study hints at insights to come from genes unique to humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that Huawei has selected ... solution for its stylish smartwatch. Huawei chose the ... reliability, low power and highly responsive human interface ... Huawei designers also required a classic round watch ...
(Date:7/23/2015)... Mass., July 23, 2015 Aware, Inc. (NASDAQ: ... today reported financial results for its second quarter ended June ... of 2015 was $4.5 million, a decrease of 33% compared ... income in the second quarter of 2015 was $0.3 million, ... or $0.04 per diluted share, in the same period a ...
(Date:7/21/2015)... July 21, 2015 Today, ZTE announced its ... as well as expected revenues in 2015 that relate to sales ... revenue guidance of approximately 2,200 MSEK for 2015. Jörgen ... leading smartphone manufacturer in China and we ... 02 5 for Axon , ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... like weather stripping, are what separates the inside from ... prevents water from seeping in, for example, or heat ... White of the National Institute of Standards and Technology ... fail. Current methods test sealants statically, by placing ...
... of costly in vitro fertilization (IVF) but with no help ... multiple embryos in an attempt to ensure that the IVF ... twin and triplet births and prematurity. But having insurance coverage ... to a new study by researchers at Yale School of ...
... available in Spanish . Making DNA sequences ... hair to the point that they take on the form of ... and is one of the lines of research in which CIC ... scientific articles and are shortly to apply for a patent. The ...
Cached Biology News:Inexpensive new instruments test building sealants under real-world conditions 2Fewer multiple births in states with insurance coverage for infertility 2DNA stretching -- A new technique being carried out at CIC microGUNE to detect illnesses 2
(Date:7/30/2015)... -- According to a new market research ... PKPD, Trial Design, Toxicity Prediction, In-house, Contract Service), by ... End Users - Global Forecast to 2020", published by ... 2,107.99 million by 2020 from USD 1,034.93 million in ... Browse more than 75 market ...
(Date:7/30/2015)... July 30, 2015  With over 60,000 customers across the globe, ISN improves the ... hiring organizations with more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 ... Headquartered in Dallas, TX , ...
(Date:7/30/2015)... ... ... As part of its 2015 growth plan and as a follow up to the recently ... Whitehouse Laboratories is pleased to announce that it has begun construction on a new Microbiological ... will be strictly dedicated to basic USP 51, USP 61, and USP 62 testing specific ...
(Date:7/29/2015)... According to a new market research report, ... , published by Mordor Intelligence, the Global market is expected ... 2020, with North America being the ... global market size. The Global market for Stem Cells is ... period of (2015-2020).      (Logo: http://photos.prnewswire.com/prnh/20150428/740799) , ...
Breaking Biology Technology:Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3
... e-mail to suggest that I was largely misunderstood when I ... stated, the idea of getting independence from technology is as ... Im chalking that up to hyperbolic use of a metaphor.) ... That genie just wont go back in the bottle ...
... Software, Inc. announced today that several healthcare organizations ... company's API LaborWorkx product. , ,Founded in 1982, API ... with customers ranging in size from 500 employees to ... software include: , , St. Alexius Medical Center -- ...
... to resist the use of e-mail on vacation or the weekend? ... respondents check email while on vacation. Most people check their email ... more than one mail address and a quarter of the respondents, ... e-mail. , ,Original air date: Saturday, July 9, 2005 , ...
Cached Biology Technology:Lamenting the loss of leisure 2Lamenting the loss of leisure 3
... The tubing prep station, 100-120 V, is ... with DNA-coated gold particles to create the source ... helium discharge with the Helios gene gun. The ... O-rings, tubing prep unit, 12 foot Nalgene nitrogen ...
... Hybridization Wash Pack provides optimized blocking ... Preparation Quality Clarifier: Ready-to-use wash solutions ... SigmaScreen(tm) APS Coated Slides for Microarrays ... Hybridization Blocking Buffer: 1L • Microarray ...
Mouse monoclonal antibody raised against a partial recombinant NR4A2. NCBI Entrez Gene ID = NR4A2...
... imaging system for detection of very low ... size. Equipped with an extreme sensitive camera ... or plants in tumor research, infectious disease ... blots. NightOWL is the only imager with ...
Biology Products: