Navigation Links
New study shows soy protein lowers non-HDL cholesterol significantly more than milk protein
Date:1/18/2011

Soy protein's ability to lower total and LDL (low-density lipoprotein or "the bad") cholesterol has been extensively studied, but the mechanism whereby soy protein lowers cholesterol remains unresolved. A new study published in the Journal of Clinical Lipidology last month shows that soy protein lowers total cholesterol and non-HDL (non-high-density lipoprotein) cholesterol significantly more than milk protein in patients with moderately high cholesterol levels.

"Non-HDL cholesterol has been shown to be a somewhat stronger predictor of cardiovascular disease and mortality risk than LDL cholesterol in population studies," said Elaine Krul, co-author of the study and nutrition discovery lead at Solae. "The fact that soy protein significantly decreased non-HDL cholesterol levels compared to milk protein in this study is very promising."

This randomized, controlled, parallel arm trial evaluated the effects of an insoluble fraction of soy protein, compared to total milk proteins with high calcium content, on the fasting lipid profile. It also assessed the potential contributions of increased excretion of bile acids and neutral sterols to their lipid-altering effects.

"The results of this study also showed that soy protein lowered non-HDL through a mechanism that does not involve increased bile acid excretion, but some yet to be determined mechanism," said Kevin Maki, lead author of the study. "Nonetheless, these results are supportive of the heart health claim for soy protein."

The Food and Drug Administration (FDA) heart health claim for soy protein established in 1999 states that "25 grams of soy protein a day, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease." Currently, 11 other countries have approved health claims for soy protein's potential to lower blood cholesterol and lower the risk of coronary heart disease.

Solae's soy protein that was used in this study was a relatively insoluble fraction of soy protein isolate that had been shown to lower plasma cholesterol and increase fecal bile acid excretion in animals. The levels of isoflavones in the soy protein were lower than the average commercial soy protein isolate further supporting the notion that isoflavones do not play a role in the cholesterol lowering. The milk protein supplemented group also showed a modest cholesterol lowering.

Subjects for this study included men and women 18 to 79 years of age with elevated cholesterol, defined as fasting LDL-cholesterol concentrations of at least 100 mg/dL and less than 200 mg/dL while receiving no lipid altering therapy. Once recruited, participants were asked to follow a Therapeutic Lifestyle Changes diet throughout the study. Subjects that still met the inclusion criteria were then screened for their ability to lower their cholesterol in response to a bile acid binding drug, colesevelam. A majority of subjects responded and were then randomized to the test protein groups.


'/>"/>

Contact: Jennifer Starkey
jstarkey@solae.com
314-659-3145
Solae, LLC
Source:Eurekalert

Related biology news :

1. Big city life may make residents lean toward green, study says
2. Columbia University uses technological innovation to study bone structure
3. Study finds fisheries management makes coral reefs grow faster
4. UCSF study identifies chemicals in pregnant women
5. Texas A&M study finds courtship affects gene expression in flies
6. Study identifies new genetic signatures of breast cancer drug resistance
7. Study estimates land available for biofuel crops
8. Researchers brave icy waters to study Arctic food web
9. Lake Erie hypoxic zone doesnt affect all fish the same, study finds
10. College students lack scientific literacy, study finds
11. Study finds energy limits global economic growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... LONDON , April 26, 2016 /PRNewswire/ ... Systems, a product subsidiary of Infosys (NYSE: ... partnership to integrate the Onegini mobile security platform ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration ... security to access and transact across channels. Using ...
(Date:4/15/2016)... April 15, 2016  A new partnership announced ... accurate underwriting decisions in a fraction of the ... priced and high-value life insurance policies to consumers ... With Force Diagnostics, rapid testing (A1C, Cotinine ... readings (blood pressure, weight, pulse, BMI, and activity ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
Breaking Biology Technology: