Navigation Links
New study shows promise in using RNA nanotechnology to treat cancers and viral infections
Date:9/4/2012

LEXINGTON, Ky. (Sept. 4, 2012) A new study by University of Kentucky researchers shows promise for developing ultrastable RNA nanoparticles that may help treat cancer and viral infections by regulating cell function and binding to cancers without harming surrounding tissue.

The study, published in Nano Today, was carried out in the laboratory of Peixuan Guo, the William S. Farish Endowed Chair in Nanobiotechnology at the UK Markey Cancer Center, in collaboration with Dr. Mark Evers, director of the UK Markey Cancer Center.

The study uses RNA (ribonucleic acid) as a building block for the bottom-up fabrication of nanostructures. Using the RNA nanotechnology pioneered by Guo, the researchers constructed ultrastable X-shaped RNA nanoparticles using re-engineered RNA fragments to carry up to four therapeutic and diagnostic modules. Their RNA nanoparticles can include small interfering RNA for silencing genes, micro-RNA for regulating gene expression, aptamer for targeting cancer cells, or a ribozyme that can catalyze chemical reactions.

The study demonstrated that regulation of cellular functions progressively increased with the increasing number of functional modules in the nanoparticle.

"RNA nanotechnology is an emerging field, but the instability and degradation of RNA nanoparticles have made many scientists flinch away from the research in RNA nanotechnology," Guo said. "We have addressed these issues, and now it is possible to produce RNA nanoparticles that are highly stable both chemically and thermodynamically in the test tube or in the body with great potential as therapeutic reagents."

The RNA nanoparticles displayed several favorable attributes: polyvalent nature, which allows simultaneous delivery of multiple functional molecules for achieving synergistic effects; modular design, which enables controlled self-assembly with defined structure; thermodynamically stable, which keeps the RNA nanoparticle
'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Study identifies prime source of ocean methane
2. New Nature study illuminates 55 million years of the carbon cycle and climate history
3. GW professor receives grant to study the role of genes in drug addiction
4. Study shows hope of greater global food output, less environmental impact of agriculture
5. Controlling gait of horses may be possible, says key study from Texas A&M
6. New study evaluates noninvasive technology to determine heart disease
7. Zebrafish study explains why the circadian rhythm affects your health
8. University of Tennessee Team receives NSF support to study toxic water in China
9. Imaging study sheds new light on alcohol-related birth defects
10. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
11. Study shows long-term effects of radiation in pediatric cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New study shows promise in using RNA nanotechnology to treat cancers and viral infections
(Date:7/28/2014)... Biologically Inspired Engineering at Harvard University today announced ... by a newly formed private company to accelerate ... products. The announcement follows a worldwide ... (OTD) and the start-up Emulate Inc., relating to ... platform. , "This is a big win ...
(Date:7/27/2014)... largest prevalence studies to date, researchers from the U.K. ... the hepatitis C virus (HCV). Findings published in Hepatology, ... of Liver Diseases, indicate that genotype 1 is the ... of which one-third reside in East Asia. Genotype 3, ... most prevalent, followed by genotypes 2, 4, 6, and ...
(Date:7/27/2014)... single computer cannot always find the solution a user ... cluster of computers that analyze a massive data set ... history to present you with targeted ads, and how ... movie. But big data is about more than just ... are generating unprecedented quantities of information. That data may ...
Breaking Biology News(10 mins):Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 2Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 3Hepatitis C virus genotype 1 is most prevalent worldwide 2New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5
... San Diego have identified a potential red tide killer. ... accumulate rapidly in dense concentrations have been on the ... dollars in worldwide losses to fisheries and beach tourism ... referred to as harmful algal blooms, remain unpredictable in ...
... Using classroom, hands-on activities can help instructors to ... Despite its importance, the diversity in soil microbes ... natural resource classrooms composed primarily of undergraduates who ... the candy comes into play. , Stephanie ...
... at City of Hope and the California Department of ... detect botulinum neurotoxin. The toxin is one of the ... and is considered a major potential bioterrorism threat agent. ... the online journal PLoS ONE ( http://www.plosone.org/doi/pone.0002041 ). ...
Cached Biology News:Scripps Oceanography Research pegs ID of red tide killer 2Scripps Oceanography Research pegs ID of red tide killer 3The sweet world of soil microbiology 2Researchers develop new ultrasensitive assay to detect most poisonous substance known 2
(Date:7/28/2014)... 28, 2014  David Hardison, Ph.D., vice president ... , has been elected chairman of the board ... non-profit working to establish common protocols around the ... relates to electronic health records. ... collaborating with organizations across the research and health ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Appistry, ... services that bring the power of genomics to next-generation ... Appistry Pipeline Challenge . , Two Appistry ... of the National Center for Genome Resources, and Mr. ... and Clinics of Kansas City. Rounding out the panel ...
(Date:7/28/2014)... -- InterMune, Inc. (NASDAQ: ITMN ) today announced ... results at the close of the U.S. markets on ... will be hosted by InterMune at 4:30 p.m. Eastern ... others may participate in the conference call by dialing ... of the webcast and teleconference will be available on ...
(Date:7/28/2014)... The National Model Aviation Museum, located ... pleased to announce that it has been granted full ... United States Air Force. , The certification is the ... this spring with an on-site inspection by Sarah Sessions, ... The National Museum of the United States Air ...
Breaking Biology Technology:ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2InterMune to Release Second Quarter Financial Results on August 6 2AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2
... FRANCISCO, March 7, 2012  More than 1,100 leaders from ... Francisco for the two-day conference CALBIO2012: Driven by Patients ... patient access to new treatments through partnering and collaborative ... BIOCOM are organizing a statewide meeting for California,s life ...
... Palatin Technologies, Inc. (NYSE Amex: PTN ) ... ROTH OC Growth Stock Conference on Tuesday, March 13, 2012, ... at the Ritz Carlton Laguna Niguel in Dana Point, CA. ... Officer of Palatin Technologies, will provide an update on Palatin,s ...
...  Synthetic Biologics, Inc.  (NYSE Amex: SYN ), ... medicines for serious illnesses, announced today that Jeff Riley, ... ROTH Capital Partners 24th Annual Growth Stock Conference. The ... Ritz Carlton in Dana Point, CA. Mr. Riley will ...
Cached Biology Technology:First Statewide Biotech Meeting Focuses on Patient Access, Innovation 2Synthetic Biologics to Present at ROTH Annual Growth Stock Conference 2
MOUSE ANTI BOVINE TROPONIN I...
NORMAL DONOR DONKEY SERUM...
This BioSolution package is excellent for doing fluorescence thermal melt experiments on nucleic acids, studies involving biomolecular interactions, protein folding experiments, and more!...
acridine orange 10-nonyl bromide (nonyl acridine orange)...
Biology Products: