Navigation Links
New study shows how nanotechnology can help detect disease earlier
Date:5/22/2012

LEXINGTON, KY. (May 21, 2012) A new study led by University of Kentucky researchers shows a new way to precisely detect a single chemical at extremely low concentrations and high contamination.

The study, published online for ACS Nano, was carried out in the laboratory of Peixuan Guo, the William S. Farish Endowed Chair in Nanobiotechnology at the University of Kentucky Markey Cancer Center. The study shows that the phi29 DNA packaging nanomotor connector can be used to sense chemicals with reactive thioesters or maleimide using single channel conduction assays based on three observable fingerprints. This channel system could be further developed into very sensitive sensing devices.

The ability to detect a chemical at a low concentration and high contamination is especially important for environmental surveillance, homeland security, athlete drug monitoring, toxin/drug screening, and earlier disease diagnosis.

In the case of disease diagnosis, the production of an unusual metabolic product is a feature of disease, but in early stages, the concentration of this product is very low. Single molecule detection will facilitate the early detection of disease such as cancer, so as to facilitate earlier treatment.

"Sensitivity of detection is a major challenge in the diagnosis of many diseases," said Guo. "Our next step is to find one metabolic product of one disease and determine the reality in earlier disease diagnosis."

"The proof-of-principle studies described in this study will be extended in the future to engineer multiple probes within a single pore for concurrent detection of multiple targets at the single molecule level in real time," said Farzin Haque, research assistant professor at the UK College of Pharmacy, and first author on the paper.


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Page: 1

Related biology news :

1. University of Leicester study finds low agreeableness linked to a preference for aggressive dogs
2. Squid ink from Jurassic period identical to modern squid ink, U.Va. study shows
3. Richer parasite diversity leads to healthier frogs, says University of Colorado study
4. Mercury in dolphins: Study compares toxin levels in captive and wild sea mammals
5. New study by WHOI scientists provides baseline measurements of carbon in Arctic Ocean
6. Florida Tech biological sciences professor earns $257,000 NSF grant to study coral diseases
7. Good news for nanomedicine: Quantum dots appear safe in pioneering study on primates
8. NIH-led study finds genetic test results do not trigger increased use of health services
9. Nottingham researchers lead worlds largest study into pre-eclampsia
10. USF study: Common fungicide wreaks havoc on freshwater ecosystems
11. Study sheds new light on importance of human breast milk ingredient
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2019)... ... January 31, 2019 , ... Pharmica Consulting announced ... operations executives and focusing on all facets of clinical trial planning and management. ... management, resource management, patient engagement, and more. , “We have attended the ...
(Date:2/2/2019)... ... February 01, 2019 , ... ... Clinical Testing Laboratories by A2LA, which establishes requirements for medical laboratories to demonstrate ... laboratory is already CLIA-licensed as well as College of American Pathologists (CAP)-accredited, a ...
(Date:1/25/2019)... ... January 24, 2019 , ... GrowthZone, Inc., ... Survey. The report indicates membership growth in some sectors and decreasing membership among ... received responses from over 500 association professionals across North America. , “This ...
Breaking Biology News(10 mins):
(Date:2/2/2019)... ... February 01, 2019 , ... ... the appointment of its new CEO, Julien Dert, being effective on February 1st, ... experience in finance and management, in which more than 12 years in the ...
(Date:1/30/2019)... ... January 29, 2019 , ... MabPlex ... (CDMO) serving the global biopharmaceutical and biotechnology industries with sites in China and ... by multiple global investors lead by China's State Development & Investment Corporation (SDIC) ...
(Date:1/30/2019)... N.C. (PRWEB) , ... January 29, 2019 , ... ... BioPharmaceutical, Inc. (AskBio), today announced the dosing of the first patient in a ... Disease is a serious disease associated with high morbidity and often leads to ...
(Date:1/30/2019)... ... January 29, 2019 , ... Could a computer detect ... a tricky math problem on an online tutoring program? Could it detect deep ... computer science assistant professor Erin Solovey is working to develop a ...
Breaking Biology Technology: