Navigation Links
New study shows how nanotechnology can help detect disease earlier
Date:5/22/2012

LEXINGTON, KY. (May 21, 2012) A new study led by University of Kentucky researchers shows a new way to precisely detect a single chemical at extremely low concentrations and high contamination.

The study, published online for ACS Nano, was carried out in the laboratory of Peixuan Guo, the William S. Farish Endowed Chair in Nanobiotechnology at the University of Kentucky Markey Cancer Center. The study shows that the phi29 DNA packaging nanomotor connector can be used to sense chemicals with reactive thioesters or maleimide using single channel conduction assays based on three observable fingerprints. This channel system could be further developed into very sensitive sensing devices.

The ability to detect a chemical at a low concentration and high contamination is especially important for environmental surveillance, homeland security, athlete drug monitoring, toxin/drug screening, and earlier disease diagnosis.

In the case of disease diagnosis, the production of an unusual metabolic product is a feature of disease, but in early stages, the concentration of this product is very low. Single molecule detection will facilitate the early detection of disease such as cancer, so as to facilitate earlier treatment.

"Sensitivity of detection is a major challenge in the diagnosis of many diseases," said Guo. "Our next step is to find one metabolic product of one disease and determine the reality in earlier disease diagnosis."

"The proof-of-principle studies described in this study will be extended in the future to engineer multiple probes within a single pore for concurrent detection of multiple targets at the single molecule level in real time," said Farzin Haque, research assistant professor at the UK College of Pharmacy, and first author on the paper.


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Page: 1

Related biology news :

1. University of Leicester study finds low agreeableness linked to a preference for aggressive dogs
2. Squid ink from Jurassic period identical to modern squid ink, U.Va. study shows
3. Richer parasite diversity leads to healthier frogs, says University of Colorado study
4. Mercury in dolphins: Study compares toxin levels in captive and wild sea mammals
5. New study by WHOI scientists provides baseline measurements of carbon in Arctic Ocean
6. Florida Tech biological sciences professor earns $257,000 NSF grant to study coral diseases
7. Good news for nanomedicine: Quantum dots appear safe in pioneering study on primates
8. NIH-led study finds genetic test results do not trigger increased use of health services
9. Nottingham researchers lead worlds largest study into pre-eclampsia
10. USF study: Common fungicide wreaks havoc on freshwater ecosystems
11. Study sheds new light on importance of human breast milk ingredient
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and ... rebranding initiative announced today. The bold new look is part of a transformation ... moves into a significant growth period. , It will also expand its service offering ...
(Date:10/10/2017)... firm Parks Associates announced today that Tom Kerber , ... Meeting , October 11 in Scottsdale, Arizona . Kerber ... smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: