Navigation Links
New study shows how nanotechnology can help detect disease earlier
Date:5/22/2012

LEXINGTON, KY. (May 21, 2012) A new study led by University of Kentucky researchers shows a new way to precisely detect a single chemical at extremely low concentrations and high contamination.

The study, published online for ACS Nano, was carried out in the laboratory of Peixuan Guo, the William S. Farish Endowed Chair in Nanobiotechnology at the University of Kentucky Markey Cancer Center. The study shows that the phi29 DNA packaging nanomotor connector can be used to sense chemicals with reactive thioesters or maleimide using single channel conduction assays based on three observable fingerprints. This channel system could be further developed into very sensitive sensing devices.

The ability to detect a chemical at a low concentration and high contamination is especially important for environmental surveillance, homeland security, athlete drug monitoring, toxin/drug screening, and earlier disease diagnosis.

In the case of disease diagnosis, the production of an unusual metabolic product is a feature of disease, but in early stages, the concentration of this product is very low. Single molecule detection will facilitate the early detection of disease such as cancer, so as to facilitate earlier treatment.

"Sensitivity of detection is a major challenge in the diagnosis of many diseases," said Guo. "Our next step is to find one metabolic product of one disease and determine the reality in earlier disease diagnosis."

"The proof-of-principle studies described in this study will be extended in the future to engineer multiple probes within a single pore for concurrent detection of multiple targets at the single molecule level in real time," said Farzin Haque, research assistant professor at the UK College of Pharmacy, and first author on the paper.


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Page: 1

Related biology news :

1. University of Leicester study finds low agreeableness linked to a preference for aggressive dogs
2. Squid ink from Jurassic period identical to modern squid ink, U.Va. study shows
3. Richer parasite diversity leads to healthier frogs, says University of Colorado study
4. Mercury in dolphins: Study compares toxin levels in captive and wild sea mammals
5. New study by WHOI scientists provides baseline measurements of carbon in Arctic Ocean
6. Florida Tech biological sciences professor earns $257,000 NSF grant to study coral diseases
7. Good news for nanomedicine: Quantum dots appear safe in pioneering study on primates
8. NIH-led study finds genetic test results do not trigger increased use of health services
9. Nottingham researchers lead worlds largest study into pre-eclampsia
10. USF study: Common fungicide wreaks havoc on freshwater ecosystems
11. Study sheds new light on importance of human breast milk ingredient
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Tenn., July 11, 2014--Researchers at the Department of ... R&D 100 awards, presented by R&D Magazine in ... , "These awards recognize the tremendous value of ... Moniz. "Research and development at the National Labs ... challenges and pursue the scientific and technological innovations ...
(Date:7/11/2014)... German . ... refraction of X-rays through a specimen instead of attenuation ... are often of much higher quality than those based ... Franz Pfeiffer are particularly interested in developing new approaches ... phase-contrast imaging. One main goal is to make this ...
(Date:7/11/2014)... develop relationships with other group members to reduce aggression ... baboons the strategy for grooming activities shows a certain ... in the scientific journal Biology Letters . , ... not practiced without ulterior motives. To be groomed has ... while grooming another individual can provide access to infants, ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4New simple setup for X-ray phase contrast 2Baboons groom early in the day to get benefits later 2
... can complicate treatment after many surgical procedures. In ... found in many healthcare settings, can be a ... the April issue of the American Journal of ... of 12 patients after refractive surgery. , These ...
... to weigh less than children who sleep less, and ... overweight five years later. That’s one of the major ... 2007 issue of the journal Child Development. , Conducted ... 2,281 children from a nationally representative survey called the ...
... $22.5 million research program at Iowa State University ... The grant is part of ConocoPhillips' plan to ... produce viable solutions to diversify America's energy sources. ... million grant in 2007 to support Iowa State ...
Cached Biology News:Drug-resistant bacterial infections serious complication after corrective eye surgery 2Children who sleep more weigh less 2ConocoPhillips establishes $22.5M biofuels research program at Iowa State 2ConocoPhillips establishes $22.5M biofuels research program at Iowa State 3
(Date:7/10/2014)... Toronto, Canada (PRWEB) July 10, 2014 ... often present in very low abundance and are ... quite challenging and time-consuming. , Join presenters Dr. ... Laboratories, and Dr. John Anders, Head of Quality ... mass spectrometer-based approach that can speed detection and ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Robert Harman, ... Veterinary Medicine company, is proud to announce the relaunch of ... launching with a new series called “ What are Stem ... give an honest and straightforward foundation in the basics of ... educated decision on the right type of treatment when considering ...
(Date:7/10/2014)... On July 9 Prime Minister ... Russia,s first national "Industry" award ... is developing a unique project called MabNext . ... number of innovative drugs based on monoclonal antibodies for ... place at the International Exhibition "Innoprom 2014" in Ekaterinburg. ...
(Date:7/10/2014)... 2014 -- According to the International Atomic Energy ... comes from terrorists acquiring sufficient quantities of plutonium ... crude nuclear explosive device. The IAEA also notes ... involved gram-level quantities, which can be challenging to ... a new study appearing this week in the ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Sensitive detection method may help impede illicit nuclear trafficking 2
... WASHINGTON , May 20 Today, world-renowned ... and his team at the J. Craig Venter Institute (JCVI) ... self-replicating cell.  The news holds groundbreaking potential for solutions to ... pharmaceuticals and vaccines; cleaning up pollution; creating new energy sources; ...
... ... University of California campuses -- San Francisco and Berkeley -- to jointly launch the first ... patient care. , ... 20, 2010 -- Former Intel Corp. chief executive Andy Grove has pledged $1.5 million to ...
... SAN FRANCISCO and WASHINGTON , ... Inc., a clinical-stage cancer biotherapeutics company, today reported positive ... the intravenous (IV) administration of JX-594 to patients with ... delivery to solid tumors, cancer-targeted replication and gene expression, ...
Cached Biology Technology:Science Channel Announces the Debut of Exclusive Look Into Dr. J. Craig Venter's Creation of Synthetic Life 2Science Channel Announces the Debut of Exclusive Look Into Dr. J. Craig Venter's Creation of Synthetic Life 3Grove Gift Launches Translational Medicine Program at UCSF & UC Berkeley 2Grove Gift Launches Translational Medicine Program at UCSF & UC Berkeley 3Grove Gift Launches Translational Medicine Program at UCSF & UC Berkeley 4Jennerex Reports Positive Phase 1 Results for JX-594 Administered Intravenously 2Jennerex Reports Positive Phase 1 Results for JX-594 Administered Intravenously 3Jennerex Reports Positive Phase 1 Results for JX-594 Administered Intravenously 4
... plus assay system offers the ... Designed for batch-processing systems, Long ... density microplates such as 384-well ... Convenient storage conditions ( 2 ...
... kit consists of universal lysis buffer, PCR ... for 100 25 l volume PCR reactions. ... Gram negative or positive rod and coccus ... Bacillus Cereus, Staphylococcus Aureus, Streptococcus Agalactiae, and ...
... The SilverQuest Silver Staining Kit ... silver staining sensitivity with minimal protein ... The mass spectrometry problems associated with ... the SilverQuest kit because the reagents ...
...
Biology Products: