Researchers at the RIKEN SPring-8 Center in Harima, Japan have clarified the crystal structure of quinol dependent nitric oxide reductase (qNOR), a bacterial enzyme that offers clues on the origins of our earliest oxygen-breathing ancestors. In addition to their importance to fundamental science, the findings provide key insights into the production of nitrogen oxide, an ozone-depleting and greenhouse gas hundreds of times more potent than carbon dioxide.
As the central process by which cells capture and store the chemical energy they need to survive, cellular respiration is essential to all life on this planet. While most of us are familiar with one form of respiration, whereby oxygen is used to transform nutrients into molecules of adenosine triphosphate (ATP) for use as energy ("aerobic respiration"), many of the world's organisms breathe in a different way. At the bottom of the ocean and in other places with no oxygen, organisms get their energy instead using substances such as nitrate or sulfur to synthesize ATP, much the way organisms did many billions of years ago ("anaerobic respiration").
While less well-known, this latter type of cellular respiration is no less important, fuelling the production of most of the world's nitrous oxide (N2O), an ozone depleting and greenhouse gas 310 times more potent than carbon dioxide. As the enzyme responsible for catalyzing the reactions underlying anaerobic respiration, nitric oxide reductase (NOR) has attracted increasing attention in environmental circles. The mystery of NOR's catalyzing mechanism, however which accounts for a staggering 70% of the planet's N2O production remains largely unsolved.
With their latest research, the team sought an answer to this mystery in the origin of an evolutionary innovation known as the "proton pump". To accelerate ATP-synthesis, aerobic organisms harness the potential of an electrochemical concentration gradient across the cell, created by "pumping"
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| Contact: RIKEN Global Relations Office gro-pr@riken.jp RIKEN Source:Eurekalert |
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