Navigation Links
New study reveals links between alcoholic liver disease and the circadian clock
Date:1/17/2014

to the development of cancer.

The liver plays many roles in the body, and includes control of metabolism, storage and release of energy molecules, and detoxification.

"Liver function changes daily in a rhythmic manner and is coordinated with cycles of feeding-fasting and to the energy demands of the body, such as activity and rest," Duffield said. "These daily rhythms are regulated by the circadian clock within those liver cells, and disturbances to the molecular clock mechanism or poor temporal coordination of the clock with the timing of eating, or the sleep-wake and rest-activity cycle, can lead to illness."

The study suggests that either the circadian clock is important in the actual development of the liver disease or that the development of steatosis disrupts the normal pattern of the clock mechanism. The researchers' findings also offer novel insights into how the disease might be manipulated for clinical purposes.

Interestingly, the mechanism by which chronic alcohol intake is thought to alter the control of fat metabolism in the liver is also a shared signal to the circadian clock mechanism, this being the ratio of production of reduced nicotinamide adenine dinucleotide, or NADH, to NAD+. The authors suggest that this may be a key to the shared disturbance to the two biological mechanisms of lipid metabolism and the circadian clock.

The study, Zhou et al., was published this week in the journal Nature: Scientific Reports.


'/>"/>

Contact: Giles Duffield
Giles.E.Duffield.2@nd.edu
574-631-1834
University of Notre Dame
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market announces that its Wocket® smart wallet will ... the Mark", scheduled to air on WABC Radio (am770) in ... . The broadcast air- time for the ... EST. NXT-ID, Inc.,s CEO Gino Pereira will be ...
(Date:6/16/2015)... CITY , June 16, 2015 /CNW Telbec/ ... their partnership centralized around the incorporation of handyem,s ... point-of-care diagnostic laboratory, the Mo-POD™. This unprecedented model ... BIO International Conference at the Pennsylvania ... from June 15 th to 18 ...
(Date:6/15/2015)... , June 15, 2015 A new ... Telstra reveals the majority of US consumers using mobile banking ... biometrics, such as fingerprint and voiceprint, instead of having to ... According to Telstra,s " Mobile Identity   -   The ... report, with smartphones now the primary channel used by Gen ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4
... Lohman, assistant professor of biology at The City College of ... a "biodiversity hotspot," could have more unique species of birds ... case, it could have important ramifications for conservation practices there. ... are endemic to this nation, which is made up of ...
... importance of the world,s natural assets is now firmly on ... showcasing the enormous economic value of forests, freshwater, soils and ... of their loss, was the conclusion of The Economics of ... leader, Pavan Sukhdev. "TEEB has documented not ...
... Entomological Foundation ( http://www.entfdn.org ), a non-profit organization whose ... educating young people about science through insects, has announced ... which are as follows: PROFESSIONAL AWARDS ... ManagementSponsored by Syngenta Crop Protection, this award is given ...
Cached Biology News:Philippines may have more unique bird species: CCNY biologist 2Philippines may have more unique bird species: CCNY biologist 3TEEB report puts world's natural assets on the global political radar 2TEEB report puts world's natural assets on the global political radar 3TEEB report puts world's natural assets on the global political radar 4TEEB report puts world's natural assets on the global political radar 5TEEB report puts world's natural assets on the global political radar 6Entomological Foundation names 2010 award winners 2Entomological Foundation names 2010 award winners 3Entomological Foundation names 2010 award winners 4Entomological Foundation names 2010 award winners 5Entomological Foundation names 2010 award winners 6Entomological Foundation names 2010 award winners 7Entomological Foundation names 2010 award winners 8Entomological Foundation names 2010 award winners 9Entomological Foundation names 2010 award winners 10
(Date:7/1/2015)... ... July 01, 2015 , ... The next-generation sequencing (NGS) clinical ... segments, including the molecular diagnostics industry. BCC Research reveals in its new report that ... lower test costs, and a growing need for better diagnostics as part of a ...
(Date:7/1/2015)... 2015   Neuraltus Pharmaceuticals, Inc. , a privately-held ... drugs to treat neurodegenerative diseases such as amyotrophic ... G. Miller , M.D., Director of the Forbes Norris ... Medical Center in San Francisco, has been awarded a ... to help fund a Phase 2 clinical study ...
(Date:7/1/2015)... July 1, 2015 Isagenix International, a leading ... three Gold, three Silver, and three Bronze Stevie® Awards ... in Chicago this month.The ... business awards program in the U.S. ... strength in developing leaders, cultivating talent, creating a unified ...
(Date:7/1/2015)... , July 1, 2015 ... technology will ... s evidence-based clinical s olutions suite   ... technical and medical information products and services, announced today the ... clinical decision support (CDS) technology company. InferMed,s Arezzo ...
Breaking Biology Technology:NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4
... John C. Lechleiter,Ph.D., president and CEO of Eli ... into the future of life sciences and a ... the sector are rewarded. He made,his remarks to ... leaders and academics, under the theme "Economic,Prosperity through ...
... from Adaptive Business Leaders (ABL) Organization Recognizes ... Transformative Advances in Healthcare, SUNNYVALE, Calif., April 30 ... in the field of radiosurgery,today announced that the company ... Business Leaders (ABL) Organization in the,"Innovations in Medical/Diagnostics Technology" ...
... Institute joins the SURGEX(TM) Team, BASKING ... wholly-owned subsidiary of Millennium Biotechnologies,Group, Inc. (OTC ... has,become the official sports nutrition drink of ... premier basketball training facility for,NBA stars and ...
Cached Biology Technology:Lilly CEO Urges Policy Prescriptions to Help Ensure Public and Private Biotech Investments Generate Dividends and U.S. Job Growth 2Lilly CEO Urges Policy Prescriptions to Help Ensure Public and Private Biotech Investments Generate Dividends and U.S. Job Growth 3Accuray Wins Innovations in Healthcare(SM) ABBY Award 2Accuray Wins Innovations in Healthcare(SM) ABBY Award 3Accuray Wins Innovations in Healthcare(SM) ABBY Award 4SURGEX(TM) Becomes the Official Sports Nutrition Drink of Former NBA Player Dee Brown and his Edge Basketball Training Facility 2SURGEX(TM) Becomes the Official Sports Nutrition Drink of Former NBA Player Dee Brown and his Edge Basketball Training Facility 3
... Precision-designed for Optimal Microdissection , CapSure ... the precise and rapid extraction of populations ... cytology samples with Laser Capture Microdissection., ... Downstream Molecular Analysis , All CapSure LCM ...
... Precision-designed for Optimal Microdissection , CapSure ... the precise and rapid extraction of populations ... cytology samples with Laser Capture Microdissection., ... Downstream Molecular Analysis , All CapSure LCM ...
... Chromo4 real-time PCR detector is an optical ... a DNA Engine or Dyad Disciple gradient-capable ... a compact scanning photonics shuttle that contains ... 500-535 nm, 555-585 nm, 620-650 nm) and ...
... highly sensitive laser confocal systems designed for ... scanners that meet your expectations, differentiating between ... optimizing the signal on the bottom as ... range for increased sensitivity. Results with VersArray ...
Biology Products: