Navigation Links
New study reveals links between alcoholic liver disease and the circadian clock
Date:1/17/2014

Researchers from the University of Notre Dame and the Indiana University School of Medicine have revealed a putative role for the circadian clock in the liver in the development of alcohol-induced hepatic steatosis, or fatty liver disease.

Hepatic steatosis is the abnormal accumulation of fats in the cells of the liver, and is linked to disturbed control of fat metabolism. Alcohol-induced liver steatosis is produced by excessive alcohol consumption and is linked to hepatitis, or inflammation of the liver. It can be a precursor to an even more serious illness, liver cirrhosis, which includes scarring of the liver. Ten percent to 35 percent of chronic heavy drinkers develop alcoholic hepatitis, and it is the main cause of liver disease in Western countries.

The team, led by associate professors Giles Duffield, from Notre Dame's Department of Biological Sciences and Eck Institute for Global Health, and Suthat Liangpunsakul from the Indiana University School of Medicine's Department of Medicine, Division of Gastroenterology and Hepatology, is interested in the molecular genetic basis for the molecular clock and liver steatosis.

The study, using molecular biological approaches and long-term alcohol feeding of experimental mice, reveals that the development of liver steatosis produced by alcohol abuse is intertwined with disturbances of the normal operation of the 24-hour clock system located in the cells of the liver. Importantly, this change in the liver clock seems to occur independently from the master clock system located in the brain.

The circadian clock regulates 24-hour rhythms in biochemistry, physiology and behavior, and its normal operation and appropriate synchronization to the external world, especially the alternating cycle of day and night, is critical to maintaining a normal healthy state. Disturbances of the clock have been linked to mental health disorders, to metabolic disease including obesity and diabetes, and to the development of cancer.

The liver plays many roles in the body, and includes control of metabolism, storage and release of energy molecules, and detoxification.

"Liver function changes daily in a rhythmic manner and is coordinated with cycles of feeding-fasting and to the energy demands of the body, such as activity and rest," Duffield said. "These daily rhythms are regulated by the circadian clock within those liver cells, and disturbances to the molecular clock mechanism or poor temporal coordination of the clock with the timing of eating, or the sleep-wake and rest-activity cycle, can lead to illness."

The study suggests that either the circadian clock is important in the actual development of the liver disease or that the development of steatosis disrupts the normal pattern of the clock mechanism. The researchers' findings also offer novel insights into how the disease might be manipulated for clinical purposes.

Interestingly, the mechanism by which chronic alcohol intake is thought to alter the control of fat metabolism in the liver is also a shared signal to the circadian clock mechanism, this being the ratio of production of reduced nicotinamide adenine dinucleotide, or NADH, to NAD+. The authors suggest that this may be a key to the shared disturbance to the two biological mechanisms of lipid metabolism and the circadian clock.

The study, Zhou et al., was published this week in the journal Nature: Scientific Reports.


'/>"/>

Contact: Giles Duffield
Giles.E.Duffield.2@nd.edu
574-631-1834
University of Notre Dame
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... smart wallet ( www.wocketwallet.com ) announces the launch of a new video ... Las Vegas , where Joey appeared at the Wocket ... Vegas , where Joey appeared at the Wocket booth to meet ... filmed at the Consumer Electronics Show (CES2016) in Las Vegas ... greet fans. --> --> The ...
(Date:1/27/2016)... Ohio , Jan. 27, 2016  Rite Track, ... based in West Chester, Ohio ... award winning service staff, based in Austin, ... capacity and ability to provide modifications, installations and technical ... Dovalina , CEO of PLUS, commented, "PLUS has provided ...
(Date:1/25/2016)... , Jan. 25, 2016  Glencoe Software, the ... pharma and publication industries, will provide the data management ... Centre (NPSC). ... Phenotypic analysis measures ... whole organisms, allowing comparisons between states such as health ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... ... states, announced today the promotion of two long-standing principal investigators (PI) to the ... Medicine, Clinical Research and Development. , Dr. Laurence Chu, a Benchmark Research PI ...
(Date:2/10/2016)... ... February 10, 2016 , ... SonaCare Medical, ... and support program, Sonalink™ remote monitoring. The inaugural launch of this new technology ... 5th, connecting Dr. Samuel Peretsman to a HIFU technical expert at SonaCare Medical ...
(Date:2/10/2016)... FL (PRWEB) , ... February 10, 2016 , ... ... in regenerative medicine, has announced a new agreement with Singapore-based Global Stem Cells ... physicians from the Philippines, Thailand and Singapore in the latest adipose and bone ...
(Date:2/9/2016)... ... February 09, 2016 , ... With a presidential election in November and ... Conference will bring together over 500 top healthcare leaders for a night and day ... conference, organized by MBA students of the University of Pennsylvania’s Wharton School, will be ...
Breaking Biology Technology: