Navigation Links
New study reveals for first time how BRCA1 mutations cause breast cancer
Date:12/9/2007

s, making it the second most mutated gene in cancer after p53. Knocking out PTEN sends a strong pro-growth signal on tumor cells. This is unlike the BRCA1 mutation, which only predisposes the cells to accumulate genetic damage and sends an indirect signal for cell growth. Once a cell loses PTEN, it has a growth advantage over its neighbors and starts on the road to cancer, said Dr. Parsons.

PTEN mutations promote runaway tumor cell growth by increasing the activity of a series of different proteins in the cell known as the PTEN/PI3K pathway. Shutting down any one of those proteins could potentially stop growth of the cancer. Investigational therapies to shut down proteins in the PTEN pathway are currently in Phase I clinical trials.

How the BRCA1 Mutation Mechanism Was Pinpointed

Dr. Parsons and his research team made the connection between BRCA1 and PTEN using techniques to search for physical chromosome breaks within the PTEN gene a technique that had never before been used. Previous searches for PTEN mutations in BRCA1 tumors had looked for conventional mutations and failed to turn up any abnormalities.

The researchers scanned 34 biopsies taken from women with BRCA1 tumors. The PTEN gene had been split in two, but inadequately repaired in about one-third of the cancers. In some cases, entire sections of the gene were missing; in others, one-half of the gene was reattached to other regions on the chromosome.

These types of large chromosomal mistakes stem directly from the tumors lack of BRCA1, a gene that is normally involved in the repair of such damage. In breast cancers from women with normal BRCA1, such large mutations in PTEN were rarely detected.

Finding May Affect 50% of BRCA1 Breast Cancers & Lead to New Treatments

Dr. Parsons estimates that about 50 percent of BRCA1 breast cancers will be found to harbor mutated PTEN once a complete analysis of chromosomal mutations is done.
'/>"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... puts into doubt the long-standing belief that a deficiency ... plays a central role in depression. In the ... mice lacking the ability to make serotonin in their ... wisdom) did not show depression-like symptoms. , Donald ... Medical Center and Wayne State University School of Medicine ...
(Date:8/27/2014)... against trans-fats have largely succeeded in sidelining the ... sugar for its potential contributions to Americans, health ... over the best way to assuage the nation,s ... Chemical & Engineering News (C&EN), the ... , In the article, Stephen Ritter, a senior ...
(Date:8/27/2014)... shown that piglets can be weaned later with no ... of the study at the University,s Roseworthy campus, published ... an important finding for pig producers. It allows improvements ... , "Sows don,t usually start their oestrous cycles again ... have been weaned," says Ms Alice Weaver, PhD candidate ...
Breaking Biology News(10 mins):New study throws into question long-held belief about depression 2Piglet weaning age no bar to litter frequency 2
... This press release is available in French , ... STOCKHOLM (24 AUGUST 2012) As food prices ... the "super drought" in the US, a new study finds that ... and climate risks in sub-Saharan Africa and South Asia. The International ...
... 2012) A nanoparticle developed at Rice University and ... may bring great benefits to the emergency treatment of ... polyethylene glycol-hydrophilic carbon clusters (PEG-HCC), already being tested to ... studies, injections of PEG-HCC during initial treatment after an ...
... a phenomenon never seen before in plants while studying molecular ... In research published online in Proceedings of the National ... team found that one member of a family of proteins ... involved in forming wood, which includes a substance called lignin ...
Cached Biology News:Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 2Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 3Farmer-led irrigation schemes could alter food security in sub-Saharan Africa, South Asia 4Nanoparticles reboot blood flow in brain 2Nanoparticles reboot blood flow in brain 3
(Date:8/27/2014)... SEATTLE , Aug. 27, 2014  ARCH ... venture firms investing in the development of seed ... its eighth venture fund closed with more than ... exceeded its $250 million subscription target by more ... Fund VIII shows the strength and potential of ...
(Date:8/27/2014)... 27, 2014 According to the 2013 ... reshape the look and feel of markets for raw ... higher-quality ingredients will push for more branded, science-backed products.” ... experienced strong market growth in the last decade as ... food and cosmetics to fit a more ‘wellness’ lifestyle ...
(Date:8/26/2014)...  NeuroSigma, Inc., a Los Angeles ... today announced that it has filed a registration statement ... Commission relating to a proposed initial public offering of ... offered and the price range for the proposed offering ... will act as the book-running manager for the proposed ...
(Date:8/26/2014)... has just been added to the growing case ... the next big thing in the high-tech world ... An international collaboration of researchers led by a ... Lawrence Berkeley National Laboratory (Berkeley Lab) has reported ... in photo-excited MX2 materials. The recorded charge transfer ...
Breaking Biology Technology:Latest ARCH Venture Partners Fund Closes Above $400 Million 2Latest ARCH Venture Partners Fund Closes Above $400 Million 3Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Competition for graphene 2
... , SAN FRANCISCO , ... a leader in Integrated Voice Response (IVR)/Integrated Web Response (IWR) ... allows users to design and deploy clinical trial Integrated Response ... of clinical trials. This time and cost savings stems from ...
... , , , , ... /PRNewswire-Asia-FirstCall/ -- Tianyin,Pharmaceutical Co., Inc., (NYSE Amex: TPI ), ... Western Pharmaceuticals,based in Chengdu, China , today announced that ... of Pricing Mechanism of Medicine,and Medical Services by the Chinese ...
... ... Divergence and National Corn Growers Association continues collaboration. , ... (PRWEB) February 9, 2010 -- Divergence, Inc. announced ... totaling $500,000, along with renewed funding from the National Corn Growers Association (NCGA), to ...
Cached Biology Technology:endpoint Saves Money and Time for Medical Research Teams Through PULSE 2endpoint Saves Money and Time for Medical Research Teams Through PULSE 3Tianyin Pharmaceutical Co., Inc. Expects to Benefit from the Recently Published Guide to Pricing Reform for Medicine and Medical Services 2Tianyin Pharmaceutical Co., Inc. Expects to Benefit from the Recently Published Guide to Pricing Reform for Medicine and Medical Services 3New Funding Validates Importance of Divergence's Work on Nematodes 2New Funding Validates Importance of Divergence's Work on Nematodes 3
Fluorescence Preserving Media, 100 mL...
Antibodies were affinity purified using epitopes specific to XLF immobilized on solid support....
...
... Clone/PAD: 3B8A10. Immunogen: ... the C-terminal region of ... Specific for the human ... Human (positive control: 293 ...
Biology Products: