Navigation Links
New study reveals for first time how BRCA1 mutations cause breast cancer
Date:12/9/2007

NEW YORK An international team of researchers led by Columbia University Medical Centers Herbert Irving Comprehensive Cancer Center and Swedens Lund University has, for the first time, revealed how mutations in the BRCA1 gene lead to breast cancer. Findings show that one way BRCA1 mutations cause cancer is by knocking out a powerful tumor suppressor gene known as PTEN.

The new study will be published online on the Nature Genetics website on Dec. 9, 2007: http://www.nature.com/ng. It will appear in the January print issue of this journal. The study was led by Ramon Parsons, M.D., Ph.D., the Avon Foundation Professor of Medicine and Pathology at Columbia University College of Physicians and Surgeons and ke Borg, Ph.D., professor of oncology at Lund University. The papers first author was Lao Saal, Ph.D. (now finishing his medical degree at Columbia University College of Physicians and Surgeons).

These findings are exciting because ever since the link was established between BRCA1 and breast cancer more than 10 years ago, we have been frustrated by our lack of understanding about how mutations in this gene cause breast cancer. We have been stymied by our limited resources to treat these cancers, which are associated with very poor prognoses. Now that we know that PTEN is involved, we finally have a target for therapy for these cancers, said Dr. Parsons, the studys corresponding author. Dr. Parsons is director of the Avon Foundation Breast Cancer Research Laboratory and director of the Breast Cancer Program of the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork-Presbyterian Hospital.

In 1997, Dr. Parsons led one of the two teams that independently discovered the PTEN, one of the most important tumor suppressor genes altered in breast cancer, as well as in brain and prostate cancers. PTEN is now recognized to be mutated in about 30 percent of all cancer
'/>"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
(Date:5/14/2015)... May 14, 2015  Verificient Technologies, Inc., ... and online remote proctoring, announced a new ... company and creator of the Canvas Learning ... two companies will benefit from the seamless ... As a fully integrated multifactor biometrics ...
(Date:5/11/2015)... Ohio , May 11, 2015  Through a well-rounded ... Ohio had a strong showing at AUVSI,s Unmanned ... These representatives of Ohio,s UAS industry ... and abroad from all points along the UAS ecosystem. ... Development Coalition,s (DDC) Vice President for Aerospace Rich Knoll ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
... Fla. If worms could talk, they might tell ... with that telltale come slither look. But worms send ... chemical code researchers are now cracking, according to a ... Nature . Scientists from the University of ...
... fire is currently burning through a study area where projections ... used data and analysis from the Gotchen Late-Successional Reserve (LSR) ... where the Cold Springs fire is now active. The Gotchen ... in Washington, and covers about 15,000 acres of the Mount ...
... a domestic renewable fuel source could generate enough electricity ... America,s entire consumption needs and lead to a significant ... research published today, Thursday, 24 July, in the Institute ... journal paper, ,Cow Power: The Energy and Emissions Benefits ...
Cached Biology News:Mate or hibernate? That's the question worm pheromones answer 2Mate or hibernate? That's the question worm pheromones answer 3Landscape study may offer solutions for fire managers 2Cow power could generate electricity for millions 2
(Date:6/2/2015)... today celebrated the North American launch of an innovative ... the size of a city block in New York ... the public, and special appearances by industry leaders and ... best total engine protection by addressing three prominent causes ... "With the launch of Shell V-Power NiTRO+ ...
(Date:6/2/2015)... MIAMI (PRWEB) June 02, 2015 Global ... Latin America distributor for Bioquark, Inc.’s biologic products for the ... is the latest in Global Stem Cells Group’s ambitious expansion ... region’s growing demand for access to regenerative medicine and stem ... on the development of biologics that have the ability to ...
(Date:6/2/2015)... YORK , Jun. 02, 2015 Tauriga ... a diversified life sciences company with interests in ... proprietary synthetic biology platform technology, today announced that ... Typenex Co-Investment, LLC ("Typenex") in exchange for a ... 16, 2015, the Company and Typenex entered into ...
(Date:6/2/2015)... , June 02, 2015 Research and ... Jain PharmaBiotech,s new report "Biomarkers - Technologies, ... This report follows the broad definition of ... objectively measured and evaluated as an indicator of ... pharmacological responses to a therapeutic intervention. Tests based ...
Breaking Biology Technology:New Shell V-Power NiTRO+ Premium Gasoline Introduces Breakthrough Formulation for BEST TOTAL Engine Protection 2New Shell V-Power NiTRO+ Premium Gasoline Introduces Breakthrough Formulation for BEST TOTAL Engine Protection 3New Shell V-Power NiTRO+ Premium Gasoline Introduces Breakthrough Formulation for BEST TOTAL Engine Protection 4Adimarket Named Latin American Distributor for Bioquark Biologic Products for the Regeneration and Repair of Human Organs and Tissue with Stem Cells 2Adimarket Named Latin American Distributor for Bioquark Biologic Products for the Regeneration and Repair of Human Organs and Tissue with Stem Cells 3Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 2Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 3Tauriga Sciences, Inc. Extinguishes All Further Obligations to Typenex Co-Investment LLC with One-Time Cash Payment of $230,000 USD 4Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 2Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 3
... , THOUSAND OAKS, Calif., Sept. 14 Amgen (Nasdaq: ... Merrill Lynch Global Healthcare Conference on Thursday, Sept. 17, 2009, in ... will present at the conference. Live audio of the presentation will ... Web site, www.amgen.com, under Investors. , , ...
... , BOTHELL, Wash., Sept. ... a leading developer, manufacturer, and marketer of biopreservation tools ... will distribute the Company,s proprietary HypoThermosol and CryoStor biopreservation ... agreement. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20090814/BIOLIFELOGO ...
... SUNNYVALE, Calif., Sept. 14 Pharmacyclics, Inc. (Nasdaq: ... commercializing innovative small molecule drugs for the treatment of immune ... financial results for the fourth quarter and fiscal year ended ... September 17, 2009 at 1:30 p.m. PDT (4:30 p.m. EDT). ...
Cached Biology Technology:BioLife Solutions Announces HypoThermosol(R) and CryoStor(TM) Distribution Agreement With Sigma-Aldrich 2BioLife Solutions Announces HypoThermosol(R) and CryoStor(TM) Distribution Agreement With Sigma-Aldrich 3Pharmacyclics Announces Date of Fourth Quarter and Fiscal Year End 2009 Conference Call 2
... This CLS number is a ... match Cornings product number. If showing ... the old Sigma-Aldrich number (Z71,517-4) or ... Material: cap polystyrene (expanded surface, easy ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Material: ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,704-5) ... assistance. ...
... The pYD1 Yeast Display Vector is ... proteins on the surface of Saccharomyces cerevisiae. ... ability to interact with known or putative ... receptor which consists of two domains, Aga1 ...
Biology Products: