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New study may explain how weight-loss surgery reverses type 2 diabetes
Date:3/24/2010

factors for cardiovascular disease in humans.

"In addition, results from the study also demonstrated that the ileal interposition surgery increases production of bile acids, which are involved in fat metabolism and can increase the production of GLP-1, the hormone that improves insulin secretion and insulin sensitivity," Havel said. "This could contribute to the delay in the onset of type 2 diabetes that we observed in the rats in this study."

He noted that further studies are needed to better understand how surgically induced improvements of metabolism can be achieved in order to discover new methods for preventing and treating type 2 diabetes. Havel, postdoctoral researcher Bethany Cummings and their colleagues have received funding from a National Institutes of Health Challenge Grant to continue to pursue research on the effects of bariatric surgical procedures in the UCD-T2DM model of diabetes.


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Contact: Patricia Bailey
pjbailey@ucdavis.edu
530-752-9843
University of California - Davis
Source:Eurekalert

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