Navigation Links
New study links excessive amounts of vitamin D to onset of atrial fibrillation
Date:11/16/2011

SALT LAKE CITY While previous studies have linked vitamin D deficiency to an increased risk for cardiovascular disease, new research at the Intermountain Medical Center Heart Institute shows that too much vitamin D can lead to the onset of a dangerous heart condition known as atrial fibrillation.

Researchers at Intermountain Medical Center, the flagship facility for the Intermountain Healthcare system, studied more than 132,000 patients and found the risk of developing atrial fibrillation was two and a half times greater in those with excess levels of vitamin D compared to patients with normal levels.

Results of the study will be presented on Wednesday, Nov. 16, at the American Heart Association Scientific Sessions in Orlando, Fla.

Atrial fibrillation is a condition in which the heart's upper chambers quiver instead of beating rhythmically, which can cause blood to pool and clot. Atrial fibrillation has been linked to an increased risk of stroke, heart failure, heart attack, dementia and even Alzheimer's disease.

T. Jared Bunch, MD, a heart rhythm specialist at the Intermountain Medical Center Heart Institute and lead investigator on the study, says the findings are significant because so many Americans use vitamin supplements to promote their health.

"There are both benefits and harm to taking vitamin supplements of all kinds," says Dr. Bunch. "Our goal is to determine a safe dose and usage range so patients can understand what amount is healthy, and what amount may be toxic."

To determine if there is a correlation between too much vitamin D and increased heart risk, Dr. Bunch and his colleagues examined blood tests from 132,000 patients in the Intermountain Healthcare database at Intermountain Medical Center.

Patients did not have any known history of atrial fibrillation, and all had previously received a vitamin D assessment as part of their routine care. Patients were then placed into categories to compare levels of vitamin D: low (less than 20 nanograms per decilter), low/normal (21-40 ng/dl), normal (41-80 ng/dl), high/normal (81-100 ng/dl), and excess (more than 100).

Patients with vitamin D levels in the normal range were compared with other groups to assess their risk of developing atrial fibrillation. In patients with low, low-normal, normal and high-normal levels of vitamin D there was no increased risk of atrial fibrillation. However, in those with excess levels of vitamin D there was a significant increased risk of atrial fibrillation. Atrial fibrillation risk was two and a half times greater in patients with excess levels of vitamin D compared to those with normal levels.

The Institute of Medicine currently advises that healthy adults should be able to take as much as 4000 IU (international units) of vitamin D daily. But the reality is that doctors don't yet know how much vitamin D causes toxicity, which is why Dr. Bunch says communication between a patient and their healthcare provider is critical.

Vitamin D, which is synthesized by the body with exposure to sun, is used to regulate calcium and phosphate concentrations in the blood and is essential for growth and development, cellular health, and bone remodeling, a process where mature bone tissue is removed from the skeleton and new bone tissue is formed.

In regions where sun exposure may be limited, supplemental vitamin D may be required to maintain normal blood levels. The exact amount of vitamin D to achieve normal levels is unknown and usage varies in different regions and communities, which can cause problems, say the researchers.

Dr. Bunch stresses that patients need to tell their doctors about all of the vitamins and supplements they take, as well as all medications, in order to ensure they get the best care possible. He says this research also suggests that checking blood levels of vitamin D in patients that develop atrial fibrillation may help uncover the cause of the abnormal heart rhythm disorder.

"Patients don't think of vitamins and supplements as drugs," says Dr. Bunch. "But any vitamin or supplement that is touted as 'healing' or 'natural' is a drug and will have effects that are both beneficial and harmful. Just like any therapy, vitamins need to be taken for the right reasons and at the right doses."

More than two millions Americans suffer from atrial fibrillation. The risk of developing atrial fibrillation increases as people age. About five percent of people over the age of 80 will develop the heart disorder during their lifetime.


'/>"/>

Contact: Jennifer Barrett
jennifer.barett@imail.org
801-408-2182
Intermountain Medical Center
Source:Eurekalert

Related biology news :

1. Study IDs new genetic links to impulsivity, alcohol problems in men
2. Forests cooler or warmer than open areas depending on latitude, study finds
3. Harm not those strangers that pollinate, study warns
4. MSU researcher sent to Siberia to study global change
5. Trees adapt to poor levels of sunlight to effectively process carbon, study shows
6. New study finds that even the cleanest wastewater contributes to more super bacteria
7. New technique enables study of challenging proteins
8. Rising air pollution worsens drought, flooding, UMD-led study shows
9. Study evaluates risk factors for chronic TMJD
10. Groundbreaking study quantifies health costs of climate-change related disasters in the US
11. Wood biofuel could be a competitive industry by 2020: UBC study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... advised by its major shareholders, Clean Technology Fund I, ... United States based venture capital funds which ... Biorem (on a fully diluted, as converted basis), that ... of their entire equity holdings in Biorem to TUS ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... will join the faculty of the University of North Carolina Kenan-Flagler Business ... strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial ... Cary 5000 and the 6000i models are higher end machines that use the more ... the spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
Breaking Biology Technology: