Navigation Links
New study into bladder regeneration heralds organ replacement treatment
Date:11/19/2010

Researchers in the United States have developed a medical model for regenerating bladders using stem cells harvested from a patient's own bone marrow. The research, published in STEM CELLS, is especially relevant for paediatric patients suffering from abnormally developed bladders, but also represents another step towards new organ replacement therapies.

The research, led by Dr Arun Sharma and Earl Cheng from the Feinberg School of Medicine at Northwestern University and Children's Memorial Research Center, focused on bone marrow mesenchymal stem cells (MSCs) taken from the patient. Previously studies into the regenerative capacity of cells in bladders have focused on animal models, but these have translated poorly in clinical settings.

"Advances in the use of bone marrow stem cells taken from the patient opens up new opportunities for exploring organ replacement therapies, especially for bladder regeneration", said senior author Sharma. "Several findings from our study have demonstrated the plasticity of stem cells derived from bone marrow which make them ideal for this type of work."

The team discovered that bone marrow mesenchymal stem cells (MSCs) have phenotypic and physiological similarities with bladder smooth muscle cells (bSMCs) implying that MSCs can serve as an alternative cell source for potentially damaged bSMCs.

"For our research we developed a primate-based model, using the baboon bladder in conjunction with bone marrow MSCs to attempt partial bladder regeneration," said Sharma. "We found that the mesenchymal stem cells utilized throughout the study retained the ability to populate a surgically grafted area while remaining active 10 weeks after surgery."

The transplanted bone marrow cells also retained the ability to express key smooth muscle cell markers, attributes that are required for the continual expansion and contractile cycles of a functional bladder.

Currently information about the ce
'/>"/>

Contact: Peggy Murphy
pmjopnes@childrensmemorial.org
773-755-6341
Children's Memorial Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Businessman-philanthropist assists TGen-VARI study of rare cancer
2. Study shows importance of exercise for those at special risk for Alzheimers
3. Study eyes fluoxetine in recreational waters
4. Human health effects of e-waste focus of international research study
5. Hearing loss study reveals role of bone hardness in tissue function
6. Study rewrites the evolutionary history of C4 grasses
7. Clemson researcher will study plutonium underground for Energy Department
8. Study shows brass devices in plumbing systems can create serious lead-in-water problems
9. Study shows young, unsupervised children most at risk for dog bites
10. Chimerix Antiviral CMX001 Inhibits JC Virus Replication in Preclinical Study; Late-Breaker Presented at Antiviral Congress 2010
11. New ocean acidification study shows added danger to already struggling coral reefs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... identified areas of the Earth that are high priorities ... Europe is particularly vulnerable, as it has the lowest ... of any continent in ,refugia, areas of biological ... remain relatively constant during times of great environmental change. ... in Scandinavia and Scotland. , The biggest refugia ...
(Date:7/28/2014)... 2014) Rice University researchers are using magnetic beads ... that can be used as microscale models for polymer ... polymers, introduced as theory in the 1950s, can be ... should be of interest to materials scientists who study ... by Rice chemical and biomolecular engineer Sibani Lisa Biswal ...
(Date:7/28/2014)... , July 28, 2014 Research and ... "Biometrics Market in Latin America 2014-2018" report to ... Biometrics measure and analyze biological data. These ... irises, eye retinas, voice patterns, and hand measurements from ... more stored templates. The main purpose of a biometrics ...
Breaking Biology News(10 mins):Study finds Europe's habitat and wildlife is vulnerable to climate change 2Seeing is bead-lieving 2Biometrics Market in Latin America 2014-2018 2
... LANSING, Mich. A Michigan State University researcher ... Prize for the design of a low-cost, energy-efficient ... commercial spaces. Norbert Mϋller, assistant professor in ... John Barrie, of the Appropriate Technology Collaborative in ...
... (EPSCoR) has received $20 million in new funding from ... Regents for Higher Education. The combined $4 million ... years and enables Oklahoma EPSCoR to support research under ... Cellulosic Bioenergy." , Specifically, the funding supports a ...
... in order to survive? The answer changes depending on climate, ... new leaf sprouts. Stanford researchers have found that the ... word stoma, meaning mouth) is controlled by a specific signaling ... stomata development. The findings are described in a paper published ...
Cached Biology News:'Cool' idea for efficient climate control wins recognition 2Oklahoma EPSCoR receives $20 million for biofuels research 2Key link in how plants adapt to climate discovered by Stanford researchers 2
(Date:7/28/2014)... 2014 The Workgroup for Electronic Data ... use of health IT to create efficiencies in healthcare ... (HPID) Workgroup has developed an issue brief titled, ... Payer?” The HPID Workgroup, a part of WEDI’s Strategic ... for Medicare and Medicaid Services (CMS) to identify common ...
(Date:7/28/2014)... -- Research and Markets has announced the ... report to their offering. ... covers the designing and engineering of completely new biological ... of natural biological systems that provide improved and desirable ... extreme genetic engineering because it not only alters existing ...
(Date:7/28/2014)... 2014 Immunomic Therapeutics, Inc. (ITI) has ... develop potential treatments for glioblastoma multiforme (GBM), the most ... their patented vaccine platform, LAMP-vax. , The agreements, ... on the work of John H. Sampson, MD, PhD, ... Robert Tisch Brain Tumor Center at Duke University Medical ...
(Date:7/28/2014)... California (PRWEB) July 28, 2014 The ... 604.40 billion by 2020, according to a new study ... with the rising demand for effective vaccines and drugs ... with unmet medical needs is expected to drive market ... need to enhance agricultural productivity via the use of ...
Breaking Biology Technology:WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2Global Synthetic Biology Market 2014-2018 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4
... Sciences Holdings, Inc. (OTC Bulletin Board: ... development and commercialization of novel drugs in the therapeutic ... that it has submitted a full proposal to the ... BAA-NIAID-DMID-NIHAI2010097 Development Of Therapeutics For Biodefense .  It ...
... imaging system, scientists have tracked a group of near-infrared ... the body and out again, providing a description of ... could be used in developing therapeutic agents to treat ... of the health effects of air pollution. ...
... 2010 Financial Results ... ... --> ... // Results are keyed by longUrl, so we need to grab the first one. for (var r in data.results) ...
Cached Biology Technology:Advanced Life Sciences Submits Full Proposal to NIAID for Development of Intravenous Formulation of Restanza as a Biodefense Countermeasure 2Advanced Life Sciences Submits Full Proposal to NIAID for Development of Intravenous Formulation of Restanza as a Biodefense Countermeasure 3Advanced Life Sciences Submits Full Proposal to NIAID for Development of Intravenous Formulation of Restanza as a Biodefense Countermeasure 4Scientist chronicle nanoparticles' journey from the lungs into the body 2Scientist chronicle nanoparticles' journey from the lungs into the body 3Oncothyreon Reports Third Quarter 2010 Financial Results 2Oncothyreon Reports Third Quarter 2010 Financial Results 3Oncothyreon Reports Third Quarter 2010 Financial Results 4Oncothyreon Reports Third Quarter 2010 Financial Results 5Oncothyreon Reports Third Quarter 2010 Financial Results 6Oncothyreon Reports Third Quarter 2010 Financial Results 7Oncothyreon Reports Third Quarter 2010 Financial Results 8Oncothyreon Reports Third Quarter 2010 Financial Results 9Oncothyreon Reports Third Quarter 2010 Financial Results 10Oncothyreon Reports Third Quarter 2010 Financial Results 11
...
... Johnstone and M.W. Turner (1997). • ... methods used in the production of ... in immunoassays, the standardisation of antibodies ... including amplification systems, enzyme immunoassays for ...
... The 1-D PAGE ... Kit for Targeted Protein ... SDS PolyAcrylamide Gel Electrophoresis ... chemistry, and cleavable-linker technology ...
Thermal Printer Paper for Monolight(tm) Luminometer 1 each...
Biology Products: