Navigation Links
New study identifies unique mechanisms of antibiotic resistance
Date:3/26/2013

ns in order to survive."

Levy and his colleagues determined that the E. coli genetically mutated four separate times in order to resist carbapenems. Specifically, the isolate removed two membrane proteins in order to prevent antibiotics from getting into the cell. The bacteria also carried a mutation of the regulatory protein marR, which controls how bacteria react in the presence of antibiotics. The isolate further achieved resistance by increasing expression of a multidrug efflux pump. Moreover, the researchers discovered that the E. coli was expressing a new protein, called yedS, which helped the drug enter the cell, but whose expression was curtailed by the marR mutation. yedS is a normally inactive protein acquired by some E. coli that affects how the drug enters the bacterial cell. It is generally expressed in bacteria through a mutation.

According to the Centers for Disease Control and Prevention, CRE germs have increased from 1% to 4% in the United States over the last decade. Forty-two states report having identified at least one patient with one type of CRE. Approximately 18% of long-term acute care hospitals in the United States and 4% of short-stay hospitals reported at least one CRE infection in the first half of 2012.

The clinical isolate of E. coli studied by Levy and his colleagues came from the sputum of a patient at Peking Union Medical College Hospital in Beijing, China, where three of the study authors are on the faculty. Drug resistance is a particularly serious public health concern in China, antibiotics are overprescribed and used widely in the livestock and farming industries.

"The first quinolone-resistant strains of bacteria came out of China, where we see that the drugs of last resort begin being used, because the other drugs don't work after so much overuse," Levy said.


'/>"/>
Contact: Jennifer Kritz
Jennifer.Kritz@tufts.edu
617-636-3707
Tufts University, Health Sciences Campus
Source:Eurekalert

Page: 1 2

Related biology news :

1. Appetite genes are key to better diets for poultry, study shows
2. Study finds strong genetic component to childhood obesity
3. Einstein study reveals new approach for stopping herpes infections
4. New lung cancer study takes page from Googles playbook
5. Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
6. Scientists awarded £3M to study the way Northwest European seas absorb carbon
7. Additional research must be done to ensure safety of pit latrines, new study says
8. UF fossil bird study on extinction patterns could help todays conservation efforts
9. Do I know you? Memory patterns help us recall the social webs we weave, finds new Cornell study
10. Study explores long-term water quality trends in near-pristine streams
11. New study highlights strong anti-cancer properties of soybeans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... -- Automation is fundamentally transforming the travel experience and ... borders. Over the past decade, ePassports, biometric readers, ... to self process through border control via eGates ... increasing number of airports, seaports, and land borders ... Maxine Most , Principal at Acuity Market ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) ... Market in India 2015-2019" report to their ... in this market is the adoption of multimodal ... one characteristic of an individual for verification and ...
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need ... your password, site key or the answer to your secret ... teacher? Today, Hoyos Labs , a ... will finally put an end to the frustration that comes ... . 1U leverages a user,s smartphone to acquire his or ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... Mutations that help HIV hide from the immune system undermine ... researchers in the April 13 issue of the Journal ... March 23. When HIV infects a cell, a ... leukocyte antigen) alert killer T cells by displaying bits of ...
... the latest American Chemical Society (ACS) Weekly PressPac from ... ACS, 34 peer-reviewed journals and Chemical & Engineering News.,Please ... as the source for this information. PressPac Archive: ... # 1 FOR IMMEDIATE RELEASE, Solving the mystery of ...
... BOSTON, Mass. (April 12, 2009) In certain respects, ... True, they have lots of components, but they also ... of people are studied in aggregate (conservatives, liberals, atheists, ... But when looked at one person at a time, ...
Cached Biology News:HIV pays a price for invisibility 2American Chemical Society Weekly PressPac -- April 8, 2009 2American Chemical Society Weekly PressPac -- April 8, 2009 3American Chemical Society Weekly PressPac -- April 8, 2009 4American Chemical Society Weekly PressPac -- April 8, 2009 5American Chemical Society Weekly PressPac -- April 8, 2009 6American Chemical Society Weekly PressPac -- April 8, 2009 7American Chemical Society Weekly PressPac -- April 8, 2009 8American Chemical Society Weekly PressPac -- April 8, 2009 9American Chemical Society Weekly PressPac -- April 8, 2009 10American Chemical Society Weekly PressPac -- April 8, 2009 11For cancer cells, genetics alone is poor indicator for drug response 2For cancer cells, genetics alone is poor indicator for drug response 3
(Date:12/19/2014)... Boston, MA (PRWEB) December 18, 2014 ... software, announced the appointment of Siri Bryant as the ... the new Director of Core Implementations. These two new ... provide outstanding customer service by ensuring that iLab continues ... , “In the last four years, iLab has been ...
(Date:12/19/2014)... The empty capsules market is experiencing growth ... technological innovations in the empty capsules market. The ... growth of the empty capsules market. , Get ... of Report , The report will enrich both ... to gauge the pulse of the market which ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group finds ... biomaterial market will grow moderately through 2023 as the ... growing awareness of dental biomaterials all spur procedure volumes. ... as China and ... dental procedures within reach for a larger proportion of ...
(Date:12/19/2014)... 18, 2014   ISN has released its ... Indicators publication series. With data aggregated from ... in 2013 within its online contractor management platform, ISNetworld, ... performance indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
Breaking Biology Technology:iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... Jan. 27, 2011 Warner Chilcott plc (Nasdaq: ... financial guidance prior to the market opening on Tuesday, February ... press release, the Company will host a conference call for ... AM (Eastern Time) to review the guidance. To participate in ...
... (GaN) and zinc oxide (ZnO) are among the ... ubiquitous today in optoelectronic elements such as blue ... zinc oxide also finds many uses in optoelectronics ... though, nanostructures made of these materials have shown ...
... Jan. 26, 2011 Sangamo BioSciences, Inc. (Nasdaq: ... fourth quarter and full year 2010 financial results on Wednesday, ... will be followed by a conference call at 5:00 p.m. ... and webcast. During the conference call, the company will review ...
Cached Biology Technology:Nanowires exhibit giant piezoelectricity 2Nanowires exhibit giant piezoelectricity 3Sangamo BioSciences Announces Fourth Quarter and Full Year 2010 Conference Call and Webcast 2
... direct, simple approach to covalently ... surface of an EIA plate ... its integrity and availability for ... room temperature conditions Open ...
... and clarification reagent; Ideal for clarifying ... antibodies, proteins, nucleic acids, & proteoglycans; ... and improves downstream processing; Utilizes a ... adsorbent supplied as a suspension in ...
AC input: 230 V...
... is designed to stabilize the biomolecules ... storage. There are neither animal ... is a convenient 10 times solution ... superior to other traditional lyophilizing additives ...
Biology Products: