Navigation Links
New study identifies unique mechanisms of antibiotic resistance
Date:3/26/2013

BOSTON (March 26, 2013) As public health authorities across the globe grapple with the growing problem of antibiotic resistance, Tufts University School of Medicine microbiologists and colleagues have identified the unique resistance mechanisms of a clinical isolate of E. coli resistant to carbapenems. Carbapenems are a class of antibiotics used as a last resort for the treatment of disease-causing bacteria, including E. coli and Klebsiella pneumonia, which can cause serious illness and even death. Infections involving resistant strains fail to respond to antibiotic treatments, which can lead to prolonged illness and greater risk of death, as well as significant public health challenges due to increased transmission of infection. The study, published in the April issue of Antimicrobial Agents and Chemotherapy, demonstrates the lengths to which bacteria will go to become resistant to antibiotics.

Resistance to carbapenems usually emerges through the acquisition of an enzyme, carbapenemase, which destroys the antibiotic intended to treat infection. Resistance may also block entry of the drug into the E-coli bacteria. The current research, led by corresponding author Stuart Levy, M.D., Professor of Molecular Biology & Microbiology and of Medicine and Director of the Center for Adaptation Genetics & Drug Resistance at Tufts University School of Medicine, sought to determine what made this particular clinical isolate of E. coli resistant to carbapenem in the absence of carbapenemase.

"The Centers for Disease Control and Prevention has documented a significant increase in Carbapenem-resistant Enterobacteriaceae (CRE) so-called 'super bugs' that have been found to fight off even the most potent treatments," Levy said. "We knew that bacteria could resist carbapenems, but we had never before seen E. coli adapt so extensively to defeat an antibiotic. Our research shows just how far bacteria will go with mutatio
'/>"/>

Contact: Jennifer Kritz
Jennifer.Kritz@tufts.edu
617-636-3707
Tufts University, Health Sciences Campus
Source:Eurekalert

Page: 1 2

Related biology news :

1. Appetite genes are key to better diets for poultry, study shows
2. Study finds strong genetic component to childhood obesity
3. Einstein study reveals new approach for stopping herpes infections
4. New lung cancer study takes page from Googles playbook
5. Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
6. Scientists awarded £3M to study the way Northwest European seas absorb carbon
7. Additional research must be done to ensure safety of pit latrines, new study says
8. UF fossil bird study on extinction patterns could help todays conservation efforts
9. Do I know you? Memory patterns help us recall the social webs we weave, finds new Cornell study
10. Study explores long-term water quality trends in near-pristine streams
11. New study highlights strong anti-cancer properties of soybeans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... at the Department of Energy,s Oak Ridge National ... by R&D Magazine in recognition of the year,s ... the tremendous value of our National Labs," said ... at the National Labs continues to help our ... scientific and technological innovations necessary to remain globally ...
(Date:7/11/2014)... Bone and Mineral Research awarded Michael F. Holick, PhD, ... the 2014 Louis V. Avioli Award. Holick, a professor ... known for revolutionizing the understanding of vitamin D and ... honors a member of the American Society for Bone ... and mineral basic research. It is named for ASBMR,s ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... Scientists propose developing an environmentally-friendly fungal spray that would ... a critical growth stage. This spray will contain ... and will have no side-effects on non-target organisms and ... therefore provide a quick, safe and effective means for ...
... the Technion Israel Institute of Technology, the ... have recently identified genes responsible for the positive ... drug Copaxone®. These findings may contribute to the ... Copaxone® was the first original Israeli drug ...
... -- A new book by researchers at the ... the mouse demonstrates a surprising similarity between mice and humans. ... by a team from the Hebrew University Bone Laboratory consisting ... Hajbi-Yonissi and Dr. Yankel Gabet. Also participating in the writing ...
Cached Biology News:New hope for horse lovers as effective control for killer ragwort is proposed 2Israeli scientists identify: Genes that affect responses of multiple sclerosis patients to copaxone 2Of mice and men: similarities between skeletons of both 2
(Date:7/11/2014)... 2014 Research and Markets  has announced ... - Global Industry Analysis, Size, Share, Growth, Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection ... DNA or RNA) into cells. This technology helps the ... and protein metabolism by affecting the nuclear genes. The ...
(Date:7/11/2014)... July 11, 2014  Researchers have pioneered a ... The new technology, called Virtual Finger, allows scientists ... like neurons and synapses using the flat surface ... makes 3D imaging studies orders of magnitude more ... unprecedented level across many areas of experimental biology. ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Deep ... Century Medicine Forum on ‘Commercialising Longevity Research’ and ... entrepreneurs to the London Bioscience Innovation Center for ... Foundation and Aging Analytics Ltd. The meeting highlighted ... in translational research for age-related disease, as well ...
(Date:7/10/2014)... Poway, CA (PRWEB) July 10, 2014 Robert ... Regenerative Veterinary Medicine company, is proud to announce the relaunch ... Pets, launching with a new series called “ What are ... to give an honest and straightforward foundation in the basics ... an educated decision on the right type of treatment when ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... 19 /PRNewswire-FirstCall/ - ARIUS Research Inc., (TSX:,ARI), a ... of,antibody therapeutics, today announced that David Young, MD, ... at the Chinese Global,Financial Forum. Dr. Young will ... will be available prior to and following his ...
... ... WEST HAVEN, Conn., Oct. 19 Dr. Heather Coyle ... Haven have,developed a new method for preparing certain skeletal remains ... the,research the group is doing for the Smithsonian Institution. Obtaining ...
... Therapeutics Inc., a,Nutritional Therapeutics Innovation Company, today announced ... Wakeman as President. "Pilot has always had ... and dietary supplement areas with over 60 issued ... potential to rapidly move our,world class technologies and ...
Cached Biology Technology:ARIUS to present at Chinese Global Financial Forum 2800-Year-Old Mummies Aid Current Cold Cases: 2Pilot Therapeutics Announces New Executive Team with Extensive Experience Creating New Health and Nutrition Businesses 2
... exciting product for cell-based kinetic assays and ... use of expensive HTS equipment, which lead ... assay development stage. The NOVOstar offers the ... well as any other assay suitable for ...
... measures mitochondria intactness and detects events ... Features and Benefits: Fast, ... isolated mitochondria and for assaying mitochondria ... reagents required for the detection of ...
... save space and organize gloves, ... other garb. They are the ... small parts used in labs, ... Open-slot design for easy cleaning. ...
... handy dispensers save space and ... hats, and other garb. They ... bins for small parts used ... Clear acrylic. Many other sizes ...
Biology Products: