Navigation Links
New study identifies novel role for PEA-15 protein in cancer growth
Date:11/21/2011

HONOLULUA new study from the University of Hawaii Cancer Center reveals that PEA-15, a protein previously shown to slow ovarian tumor growth and metastasis, can alternatively enhance tumor formation in kidney cells carrying a mutation in a cancer-promoting gene called H-Ras.

The H-Ras oncogene is mutated in many human malignancies, and previous reports have shown the ability of H-Ras to contribute to the development, proliferation and metastasis of these tumors. Conversely, PEA-15 had been reported to inhibit tumor cell proliferation and metastasis by opposing H-Ras signals. In ovarian and breast cancer, PEA-15 is proposed to have promising therapeutic potential and in ovarian cancer PEA-15 has shown promise as a marker of prolonged patient survival.

This new study is the first finding of a pro-cancer effect of PEA-15 on proliferation and as such suggests caution in pursuing the use of PEA-15 as an anti-cancer therapeutic. The study results were published online today in the journal Oncogene.

"Our findings reveal a surprising mechanism by which PEA-15 can enhance H-Ras driven transformation of cells, rather than stop it," said Joe W. Ramos, Ph.D., associate professor at the University of Hawaii Cancer Center and co-director of its Cancer Biology Program. "We showed that in a common scenario in which a cell contains a Ras mutation, PEA-15 can accelerate the rate of tumor formation both in vitro and in vivo," he added.

In contrast to reports suggesting a tumor-suppressor function of PEA-15, Ramos said the discovery confirms that PEA 15 expression can also trigger tumor growth. "What we now know is that PEA-15 can either enhance or impair the formation of tumors depending on the signaling pathways active in a specific tumor cell."

"As with most cancers, an interplay of factors determines the fate of a patient," noted Florian Sulzmaier, a researcher at the UH Cancer Center and first author of the newly published
'/>"/>

Contact: Kellie Tormey
ktormey@cc.hawaii.edu
808-564-5814
University of Hawaii Cancer Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Dallas research widens study of brains role in tinnitus
2. Study of flower petals shows evolution at the cellular level
3. Study explains how heart attack can lead to heart rupture
4. Study details links between climate, groundwater availability - will help states prepare for drought
5. Long-term study shows acid pollution in rain decreased with emissions
6. New study links excessive amounts of vitamin D to onset of atrial fibrillation
7. Study IDs new genetic links to impulsivity, alcohol problems in men
8. Forests cooler or warmer than open areas depending on latitude, study finds
9. Harm not those strangers that pollinate, study warns
10. MSU researcher sent to Siberia to study global change
11. Trees adapt to poor levels of sunlight to effectively process carbon, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Scientists at The New York Stem Cell ... to creating a viable cell replacement therapy for ... , For the first time, NYSCF scientists generated ... samples of patients with primary progressive multiple sclerosis ... induce these stem cells into becoming oligodendrocytes, the ...
(Date:7/24/2014)... 2014) Scientists at The New York Stem ... closer to creating a viable cell replacement therapy ... , For the first time, NYSCF scientists ... skin samples of patients with primary progressive multiple ... to induce these stem cells into becoming oligodendrocytes, ...
(Date:7/24/2014)... factors that characterize sustainable university and college programs ... physics teachers. Specifically, one or more faculty members ... combination with institutional motivation and commitment can ensure ... and Math (STEM) teacher shortages are especially acute ... for institutions seeking to increase the number of ...
Breaking Biology News(10 mins):NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2Creating sustainable STEM teacher preparation programs 2
... his research team at the Centre for Stem Cell Research ... ( http://dev.biologists.org/ ) a new and safer way of ... give rise to every tissue of the body. Rapid developments ... way for stem cell scientists to convert specialised cells, such ...
... Just the mention of this iconic spring and early ... drinks and sweet desserts. Researchers interested in learning more ... of strawberries, a strong influence on consumer preferences, is ... texture, and appearance. The goals of a recent ...
... most often as a healthy, convenient food, are also ... plants are highly prized by many as one of ... ambiance in gardens and pool environments. A research ... journal HortTechnology detailed a study of 33 ...
Cached Biology News:Researchers piggyback to safer reprogrammed stem cells 2Analysis of fresh strawberries reveals consumer preferences 2
(Date:7/24/2014)... , July 24, 2014 Research ... "Global Cell Culture Market 2014-2018" report to ... Cell culture is the in vitro growth ... as research, cell studies, and biopharmaceutical production. Cell culture ... production. Cell culture instruments and cell culture consumables are ...
(Date:7/24/2014)... California (PRWEB) July 24, 2014 ... to advances in modeling lithium-ion battery storage capacity. ... benefit from a theoretical model created at ... University that predicts how carbon components will ... energy storage emphasizes the urgent need for higher-performance ...
(Date:7/24/2014)... 24, 2014  CorMedix Inc. (NYSE MKT: CRMD), ... therapeutic products for the prevention and treatment of ... notice on July 18, 2014 from the NYSE ... the CorMedix plan to regain compliance with continued ... the NYSE-MKT is continuing the Company,s listing and ...
(Date:7/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Sulphate basic information, including its definition, classification, ... This research covers the international market analysis, including ... analysis covering macroeconomic environment & economic situation analysis, ...
Breaking Biology Technology:Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2Getting More Life out of Lithium-ion Batteries 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... Valencia (UV) has confirmed that the substance used to hermetically ... was pine resin. The scientists also studied the metallic fragments ... used for iron-working. In 2005, a group of archaeologists ... at Lixus, an ancient settlement founded by the Phoenicians near ...
... CRANBURY, N.J. , Feb. 5 Amicus Therapeutics ... has elected John F. Crowley as Chairman of the ... (CEO), effective immediately.  Mr. Crowley will succeed Donald J. Hayden, ... Board. , "The Board,s decision to elect Mr. Crowley as Chairman ...
... Stuart Lindsay, Arizona State University Regents, professor and director ... has just released the first comprehensive guide to a ... grain of sand. Introduction to Nanoscience (published by ... an emerging discipline which has in recent years, produced ...
Cached Biology Technology:Chemical analyses uncover secrets of an ancient amphora 2Amicus Therapeutics Board of Directors Names Chief Executive Officer John F. Crowley Chairman of the Board 2Big book explores a small world: Stuart Lindsay's guide to nanoscience 2Big book explores a small world: Stuart Lindsay's guide to nanoscience 3