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New study helps to explain why breast cancer often spreads to the lung
Date:4/24/2014

d growth into metastatic tumors," explains Allan, an associate professor in the Departments of Oncology, and Anatomy and Cell Biology at Western's Schulich School of Medicine & Dentistry. "A lot of research has been done on the cancer cells because they're easy to study, but not a lot has gone into understanding the 'soil factor.' We've uncovered some specific proteins that are produced in the lung that seem to interact with cancer stem cells, making the lungs a congenial place for cancer cells to grow."

The research was funded by the Canadian Breast Cancer Foundation- Ontario Region. Looking forward, the translation of this knowledge to the clinic could have important future implications for improved treatment of breast cancer. The results of this study will also lay the groundwork for future clinical studies aimed at investigating whether increased breast CSCs in the primary tumor may pre-dispose some patients to lung metastasis, and if so, whether directed monitoring (i.e. by imaging or ex vivo analysis) may be beneficial for early detection and successful treatment.


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Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

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