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New study finds way to stop excessive bone growth following trauma or surgery
Date:9/23/2009

or cells can form cartilage tissue. The Jefferson scientists, using a pharmacological agent, an alpha agonist, kept the receptors active, stifling the initiation of the disease in its tracks.

"The agonist we used in this case is an experimental drug that is not on the market yet, but is being tested in Phase II human trials for another disease. We tested whether the drug could work to prevent HO, thereby looking for another application for the drug," said Pacifici.

HO treatments for the general population exist now, but are not always effective and can produce side effects. Low-dose irradiation, postoperative nonsteroidal anti-inflammatory drugs or a combination of both are the current routine treatments for HO. When these treatments fail and patients require surgical removal of HO lesions, some complications can arise, including instigation of a new round of HO formation. These treatments are currently not used in wounded soldiers because they could have additional complications. For example, low-dose irradiation could reduce the healing capacity of tissues. Since the alpha agonist should not interfere with these processes, it could prove to be a suitable treatment without the significant side effects.

Because current HO treatments cannot be used, HO remains a potentially serious problem due to the high incidence among military personnel. Also without treatment, HO can progress and spread becoming much more serious over time. Hopefully, if clinical trials are done and prove successful this treatment could be used as a cure for not only HO but for other HO-related diseases including Fibrodysplasia Ossificans Progressive (FOP), an inheritable and severe form of HO.

"We aren't there yet but we are definitely excited," concluded Pacifici.


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Contact: Rick Cushman
richard.cushman@jefferson.edu
215-955-2240
Thomas Jefferson University
Source:Eurekalert

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