Navigation Links
New study finds uncontrollable stress worsens symptoms of endometriosis
Date:4/7/2008

SAN DIEGO, CA Endometriosis is a poorly understood condition that incapacitates and affects the productivity and lifestyle of millions of women around the world. In the US, it affects approximately six million women and adolescents at a cost of some $1.6 billion per year. It is a chronic painful disease which occurs when endometrial tissue grows as lesions outside the uterus, mainly in the area of the ovaries and fallopian tubes, but can also affect the intestinal tract. The condition results in chronic pelvic pain, painful menstrual periods and pain during intercourse.

Many patients report suffering from high levels of stress due to the impact that painful symptoms have on all aspects of their life, including work, family and personal relationships. For example, the physical pain they experience during intercourse can disrupt a healthy sexual relationship, thus causing anguish and discord which leads to further stress.

Circumstantial evidence suggests that a variety of stress management techniques can help women handle stressful situations related to the disease. However, it is not yet known whether stress affects the prevalence or progression of the disease.

A new study investigating the relationship between stress and the painful symptoms of the disease is currently underway. It offers, for the first time, evidence of the negative consequences of stress in the progression of endometriosis, most likely through an effect on the immune system.

Presentation at the 121st Annual Meeting of the American Physiological Society

The study was conducted by an interdisciplinary team of investigators with expertise in endometriosis, animal physiology and behavior. Marielly Cuevas, Olga I. Santiago, Kenira J. Thompson and Caroline B. Appleyard, Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, Puerto Rico, and Idhaliz Flores of the Department of Microbiology. Dr. Appleyard and her graduate student, Marielly Cuevas, will present the teams findings, entitled The Pathophysiology of Intestinal Endometriosis is Exacerbated by Uncontrollable Stress during the 121st annual meeting of The American Physiological Society (APS; www.the-APS.org/press), part of the Experimental Biology 2008 scientific conference.

The Study

Seven female rats were induced with endometriosis. Of the total, half were subjected to stressful swim tests for ten consecutive days, a chronic and stressful situation the animals could not control. The endo-stress group (n=3) was subjected to the swim trials. The endo-control rats (n=4) had endometriosis but did not swim. The sham-stress group (n=3) did not have the disease nor did they swim.

Sixty days after the induction of the endometriosis the rats were sacrificed and examined for the presence of endometriotic vesicles (small structures inside cells used to transport liquids such as proteins), and damage to the adjacent organs (including the colon and small intestine). The presence of the enzyme myeloperoxidase (MPO), which is linked to inflammation, was also assayed.

Results

The researchers found that:

  • none of the sham-stress animals developed vesicles.

  • the endo-control group developed a total vesicle length that averaged 6.570.96mm per animal.

  • the endo-stress group developed a total vesicle length that averaged 11.265.27mm per animal.

  • the endo-control rats had higher colonic damage scores than sham-stressed animals, which was increased further by stress.

  • the endo-stress rats had the shortest colon length, the highest levels of MPO, the greatest number of colonic mast cells, and an increase in peritoneal fluid immune cell infiltration, all indicative of activation of inflammatory mechanisms.

Conclusion

According to the senior researcher for the study, Dr. Appleyard, These findings contribute to our understanding of how stress may affect the severity of endometriosis. We think there is likely a connection with the immune system because of the observed levels of mast cells in the colon and the increased levels of inflammatory cells in the peritoneum of the affected rats, since this has also been observed in patients with endometriosis. Appleyard continued, The results offer a jumping off point to help identify stress-management interventions that will help those women who are affected by the disease.


'/>"/>

Contact: Donna Krupa
DKrupa@the-aps.org
619-525-6202
American Physiological Society
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/30/2017)... -- Trends, opportunities and forecast in this market to ... AFIS, iris recognition, facial recognition, hand geometry, vein recognition, ... industry (government and law enforcement, commercial and retail, health ... and by region ( North America , ... , and the Rest of the World) ...
(Date:3/28/2017)... March 28, 2017 The report ... (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), ... - Global Forecast to 2022", published by MarketsandMarkets, the ... and is projected to reach USD 75.64 Billion by ... 2022. The base year considered for the study is ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... , ... August 23, 2017 , ... NDA Partners Chairman ... Director of the Office of Device Evaluation at the FDA’s Center for Devices and ... joined the firm as an Expert Consultant. , Prior to his FDA experience, Dr. ...
(Date:8/22/2017)... ... August 22, 2017 , ... Cutting ... distribution of highly differentiated spinal implant technologies, announced today the appointment of Luke ... of spinal device industry experience to directing Cutting Edge Spine’s national sales force, ...
(Date:8/22/2017)... ... August 22, 2017 , ... KBioBox ... patented KBioBox technology, the extended GUIDE-Seq ananlysis. KBioBox has adapted their core technology ... be provide scientists with easy to understand reports, extended indel analysis, and translocation ...
(Date:8/21/2017)... ... 2017 , ... MacArthur Sotheby’s International Realty, a luxury real ... the first Delos Wellness Signature™ residence in Hawaii is on the market for ... listing agent Kelly Allen, R(S) of Carvill Sotheby’s International Realty located on Oahu, ...
Breaking Biology Technology: