Navigation Links
New study examines immunity in emerging species of a major mosquito carrer of malaria
Date:12/20/2010

In notable back-to-back papers appearing in the prestigioous journal Science in October, teams of researchers, one led by Nora Besansky, a professor of biological sciences and a member of the Eck Institute for Global Health at the University of Notre Dame, provided evidence that Anopheles gambiae, which is one of the major mosquito carriers of the malaria parasite in Sub-Saharan Africa, is evolving into two separate species with different traits.

Another significant study appearing in this week's edition of the Proceedings of the National Academy of Sciences (PNAS) and also led by Besansky suggests that the mosquitoes' immune response to malaria parasites, mediated by a gene called "TEP1," is one of the traits that differ between the two forms of Anopheles gambiae.

Both papers have major implications for malaria controls efforts and could eventually lead to new malaria prevention efforts.

The Science papers described a painstaking genomic analysis by Besansky and an international consortium of scientists that revealed that the two varieties of Anopheles gambiae, called M and S, which Besansky describes as physically indistinguishable, are evolving into two distinct species.

In the new PNAS study, the researchers performed genome-wide comparisons of M and S to pinpoint the genetic differences that could help explain how they are adapting to different larval habitats. One of the genomic regions with the most pronounced differences between M and S contained the TEP1 gene.

The researchers report that they found a distinct resistance allele (one of two or more forms of the DNA sequence of a particular gene) of TEP1 circulating only in M mosquitoes despite the fact that M and S mosquitoes live side-by-side in many parts of Africa. The authors demonstrated that this allele confers resistance to human malaria parasites. The patterns of genetic and geographic variation in the TEP1 gene suggest that this resistance allele a
'/>"/>

Contact: Nora Besansky
beasansky.1@nd.edu
574-631-9321
University of Notre Dame
Source:Eurekalert

Page: 1 2

Related biology news :

1. New study focuses on nitrogen in waterways as cause of nitrous oxide in the atmosphere
2. SU biologist partners with National Park Service to study bison grazing in Yellowstone
3. Despite damage, membrane protein structure can be seen using new X-ray technology, study reveals
4. CSHL study finds that 2 non-coding RNAs trigger formation of a nuclear subcompartment
5. Consortium studying mathematical modeling of influenza infection
6. Study shows garlic could protect against hip osteoarthritis
7. New study suggests almonds may help reduce risk of type 2 diabetes and heart disease
8. Study shows caffeine negatively affects children
9. New study about Arctic sea-ice, greenhouse gases and polar bear habitat
10. Opportunity leads to promiscuity among squirrels, study finds
11. UC Davis study: Wild salmon decline was not caused by sea lice from farm salmon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... business incubator, received a $1.4 million federal grant to ... staunch bleeding during brain surgery. , Surgeons can spray ... bio-polymer solutions in the gel will cohere and control ... The gel can shorten an intracranial surgery by 30- ... the patient,s skull to be open and less anesthesia, ...
(Date:7/10/2014)... State University have developed a small, portable and ... over the world better understand the radiation around them, ... poses a health risk. , The device was developed ... incident in Fukushima, Japan, in 2011, when many regional ... being exposed to and whether their homes, food, environment ...
(Date:7/10/2014)... Cancer Research Centre (CNIO) Macromolecular Crystallography Group has ... called BuD to DNA in order to redirect ... researcher who led the study, says the discovery: ... instructions contained in the genome to treat genetic ... is published in the journal Acta Crystallographica, ...
Breaking Biology News(10 mins):A start-up at NJIT develops bleeding-control gel for brain surgery 2Sophisticated radiation detector designed for broad public use 2Sophisticated radiation detector designed for broad public use 3CNIO scientists develop technology to redirect proteins towards specific areas of the genome 2
... Singapore unravel the inner workings of cells, invent a ... broadband communications for multimedia gaming and IPTV, and explore ... some of the winning works of this years National ... three National Science Awards (NSA), two National Technology Awards ...
... received an offer to establish its first foreign institute in ... proposed the sum of $86.9 million for the next 10 ... State of Florida will contribute funds to complete the financing, ... will take place. The County,s decision paved the ...
... YORK (Sept. 10, 2007) -- It,s well known that ... health problems from cancer to heart disease. Now a ... York City looks at how they do their dirty ... arteries. The evidence points to nicotine, the addictive chemical ...
Cached Biology News:Singapore National Science and Technology Awards 2Singapore National Science and Technology Awards 3Singapore National Science and Technology Awards 4Singapore National Science and Technology Awards 5Palm Beach County wants to establish a Max Planck Institute in Florida 2Nicotine may accelerate atherosclerosis, may be as dangerous as tar 2Nicotine may accelerate atherosclerosis, may be as dangerous as tar 3
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... research solutions, today announced that Lupin Limited, one of ... Freeslate’s CM Protégé PharmD System for high ... Mumbai, India, is focused on a wide range of ...
(Date:1/14/2014)... CA (PRWEB) January 14, 2014 Histogen, ... the products of cells grown under simulated embryonic conditions, ... license agreement with Suneva Medical, Inc. for physician-dispensed aesthetic ... , This agreement is an amendment to ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo announced ... from the National Institutes of Health (NIH) to help ... effective treatments to patients on a faster timeline. Organovo ... Sciences (NCATS) and the National Eye Institute (NEI) to ...
(Date:1/14/2014)... 2014   Kinaxis ®, provider of RapidResponse ®, a ... operations planning ( S&OP ) service, is proud to be ... will be held at the Hilton San Diego Bayfront, January ... Elisabeth Kaszas , Director of Supply Chain at Amgen, ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Sigma-Aldrich(TM) (Nasdaq:,SIAL), a life science company dedicated ... world,s researchers, and Oxford,BioMedica (LSE: OXB), a leading ... key order confirming the strength and validity of,intellectual ... in,the research field to Sigma-Aldrich. The ruling was ...
... antibody uses novel approach to "de-cloak" cancers -, ... Inc., (TSX:,ARI), a biotechnology company discovering and developing ... new findings have been,presented from its Trop-2 and ... Trop-2 and CD59 abstracts at the AACR press,conference ...
... Novocell, Inc., a leading stem cell,engineering company, today ... Vice President, Clinical & Regulatory Affairs of,Amylin Pharmaceuticals, ... Kolterman joined Amylin in 1992 and has served ... until present and as Senior,Vice President, Regulatory Affairs ...
Cached Biology Technology:Sigma-Aldrich and Oxford BioMedica Win Key Ruling in Open Biosystems Patent Infringement Dispute 2Sigma-Aldrich and Oxford BioMedica Win Key Ruling in Open Biosystems Patent Infringement Dispute 3Arius announces new findings in Trop-2 and CD59 CANCER antibody programs 2Arius announces new findings in Trop-2 and CD59 CANCER antibody programs 3Novocell Appoints Orville G. Kolterman, M.D. to Board of Directors 2
This buffer is Specifically formulated to be used with Endogen's Poly-HRP Streptavidin...
... Analyst Software has been optimized for the ... allow the software to quickly and accurately ... well of an ELISA plate or each ... Software has been customized to incorporate standard ...
... An easy-to-use solution that enables fully automated ... 400 Hybridization Station has been designed to ... the throughput necessary to perform a wide ... performed in the range 485C; denaturations of ...
The Piezo Power MicroDissection (PPMD) system is designed for rapid isolation of single cells or small cell areas...
Biology Products: