Navigation Links
New study discovers powerful function of single protein that controls neurotransmission
Date:5/13/2012

t half century that calcium is a key controller of neurotransmission," he says. "Any small change in calcium influx has a big impact on neurotransmission."

Protein Acts like a Shipping Label

But the number of calcium channels at the synapse is not static. Neurons constantly replace worn out channels, and to do this, they build the channels in the neuron's cell body and then package them up and ship them to the nerve terminal. In some cases, that is a very long journey -- as much as a few feet, such as the distance between the brain and the base of the spinal cord or the length of a leg.

In the study, researchers tagged fluorescent proteins onto a gene that encodes protein that makes a calcium channel and delivered it to neurons. They then watched the progress of the newly formed channels as they made their way, from day four to day seven, from the bodies of neurons to the synapse.

They also manipulated the levels of alpha 2 delta, a suspected calcium channel partner, and discovered that when the protein was increased, more calcium channels were moved to the synapse. Less alpha 2 delta reduced the flow. "We discovered that alpha 2 delta made the decision of how many calcium channels should be shipped the length of the neuron to the synapse," Dr. Ryan says. "It's like the channels couldn't be transported without an alpha 2 delta shipping label."

The research team found however that alpha 2 delta must work in at least two steps. When they impaired a piece of alpha 2 delta that resembles proteins that are involved in how cells bind to each other, they found that this broken alpha 2 delta could still help get calcium channels shipped down to synapses. But once there, they no longer helped drive neurotransmitter release. "This means that not only does alpha 2 delta help to get calcium channels shipped out, but it also implies that something at the synapse has to sign-off on receiving the calcium channels, putting them in
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Plastic trash altering ocean habitats, Scripps study shows
2. Study raises questions about use of anti-epilepsy drugs in newborns
3. First satellite tag study for manta rays reveals habits and hidden journeys of ocean giants
4. Successful stem cell differentiation requires DNA compaction, study finds
5. UGA study finds theres not always safety in numbers when it comes to extinction risk
6. New study published on fertility awareness among American university students
7. Study: Men who do load-bearing exercise in early 20s may be shielded from osteoporosis
8. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
9. Plant diversity is key to maintaining productive vegetation, U of M study shows
10. Study discovers genetic pathway impacting the spread of cancer cells
11. TGen leads new National Institutes of Health study of brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... , June 27, 2014  Pomerantz LLP has ... Inc. ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain ... United States District Court, Middle District of ... behalf of a class consisting of all persons ... securities between December 17, 2013 and May 22, ...
(Date:7/10/2014)... Conn. , July 2, 2014 NXT-ID, Inc., (OTCQB: ... reports that CEO Mr. Gino Pereira was interviewed ... show in Tampa Florida . Mr. Pereira ... host Cedric Harris and how the Wocket™ aims ... alternative.  Cedric Harris tells Gino ...
(Date:7/10/2014)... Fingerprint Cards, (FPC,s) new ... (DW). An Asian OEM has selected FPC1021 for a flagship ... August 2014.   FPC is proud to announce ... planned date for start of mass production in August 2014. ... 5M, for delivery in the first half of July. The ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... a looming water crisis, driven by climate change, growing ... of this issue, the National Science Foundation has selected ... Engineering Research Center (ERC) to address this challenge by ... initial grant is $18.5 million spread over five years, ...
... Scientists at the U.S. Department of Energy,s (DOE) Brookhaven ... the metabolic processes in rapeseed plants - particularly those ... Their goal is to find ways to optimize the ... renewable resources for fuel and industrial chemicals. The ...
... ,(Phoenix ... awarded Robert Garfield, PhD, a researcher at St. Joseph,s Hospital and Medical ... to prevent post-partum hemorrhage. The grant was one of 88 awarded ... help lower the barriers for testing innovative ideas in global health. Phase ...
Cached Biology News:Re-inventing America's urban water infrastructure 2Re-inventing America's urban water infrastructure 3Re-inventing America's urban water infrastructure 4Modeling plant metabolism to optimize oil production 2Modeling plant metabolism to optimize oil production 3
(Date:7/10/2014)... July 10, 2014 Research and Markets ... the "International Photonic Integrated Circuit (Monolithic Integration, ... 2019" report to their offering. ... concept of photonic integration traces its roots in ... promise of photonic integration went unexplored and unfulfilled ...
(Date:7/10/2014)... April 15, 2014 -- According to the International ... nuclear security comes from terrorists acquiring sufficient quantities ... construct a crude nuclear explosive device. The IAEA ... trafficking have involved gram-level quantities, which can be ... According to a new study appearing this week ...
(Date:7/10/2014)... June 17, 2014 Using microscopic polymer light ... gases, researchers at MIT,s Quantum Photonics Laboratory have ... in the parts-per-billion range. Optical sensors are ideal ... high signal-to-noise ratio, compact, lightweight nature, and immunity ... sensors had been developed before, the MIT team ...
(Date:7/10/2014)... psychiatric disorders has been extremely challenging because there are ... insufficient to cause disease. Now investigators reporting in the ... Cell Stem Cell describe a strategy that may ... other risk factors or environmental exposures to affect the ... genetic variant that may predispose individuals to schizophrenia. ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2
... 11 Idenix Pharmaceuticals, Inc., (Nasdaq: IDIX ... results for the fourth quarter of 2008 on Tuesday, ... conjunction with the issuance of the press release, Idenix ... ET on Tuesday, February 17, 2009 to discuss the ...
... XTL,Biopharmaceuticals Ltd. (Nasdaq: XTLB ; TASE: ... Shweiger have been appointed to XTL,s Board of,Directors, effective ... assuming,the role of Co-Chief Executive Officer, with no remuneration, ... Ron Bentsur, Co-Chief Executive Officer ...
... Victhom Human Bionics Inc., "Victhom" (TSX: VHB), announced today ... and treatment of a physiological disorder that most likely ... seizure. , Victhom has recently filed a patent application ... sudden unexpected death in epilepsy (SUDEP) using its neuromodulation ...
Cached Biology Technology:XTL Biopharmaceuticals Announces Appointment of David Grossman and Boaz Shweiger to Board of Directors 2XTL Biopharmaceuticals Announces Appointment of David Grossman and Boaz Shweiger to Board of Directors 3Victhom announces the filing of a patent application to address sudden unexplained death in epilepsy (SUDEP) 2Victhom announces the filing of a patent application to address sudden unexplained death in epilepsy (SUDEP) 3
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSES 1,HIF-1 responsive RTP801...
4-Hydroxy-3-iodo-5-nitrophenylacetyl hapten is conjugated to BSA protein through lysine by amide bonds....
Biology Products: