Navigation Links
New study discovers powerful function of single protein that controls neurotransmission
Date:5/13/2012

t half century that calcium is a key controller of neurotransmission," he says. "Any small change in calcium influx has a big impact on neurotransmission."

Protein Acts like a Shipping Label

But the number of calcium channels at the synapse is not static. Neurons constantly replace worn out channels, and to do this, they build the channels in the neuron's cell body and then package them up and ship them to the nerve terminal. In some cases, that is a very long journey -- as much as a few feet, such as the distance between the brain and the base of the spinal cord or the length of a leg.

In the study, researchers tagged fluorescent proteins onto a gene that encodes protein that makes a calcium channel and delivered it to neurons. They then watched the progress of the newly formed channels as they made their way, from day four to day seven, from the bodies of neurons to the synapse.

They also manipulated the levels of alpha 2 delta, a suspected calcium channel partner, and discovered that when the protein was increased, more calcium channels were moved to the synapse. Less alpha 2 delta reduced the flow. "We discovered that alpha 2 delta made the decision of how many calcium channels should be shipped the length of the neuron to the synapse," Dr. Ryan says. "It's like the channels couldn't be transported without an alpha 2 delta shipping label."

The research team found however that alpha 2 delta must work in at least two steps. When they impaired a piece of alpha 2 delta that resembles proteins that are involved in how cells bind to each other, they found that this broken alpha 2 delta could still help get calcium channels shipped down to synapses. But once there, they no longer helped drive neurotransmitter release. "This means that not only does alpha 2 delta help to get calcium channels shipped out, but it also implies that something at the synapse has to sign-off on receiving the calcium channels, putting them in
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Plastic trash altering ocean habitats, Scripps study shows
2. Study raises questions about use of anti-epilepsy drugs in newborns
3. First satellite tag study for manta rays reveals habits and hidden journeys of ocean giants
4. Successful stem cell differentiation requires DNA compaction, study finds
5. UGA study finds theres not always safety in numbers when it comes to extinction risk
6. New study published on fertility awareness among American university students
7. Study: Men who do load-bearing exercise in early 20s may be shielded from osteoporosis
8. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
9. Plant diversity is key to maintaining productive vegetation, U of M study shows
10. Study discovers genetic pathway impacting the spread of cancer cells
11. TGen leads new National Institutes of Health study of brain tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... of researchers at Louisiana Tech University has ... consumer-grade 3D printers and materials to fabricate ... and chemotherapeutic compounds for targeted drug delivery. ... and research faculty from Louisiana Tech,s biomedical ... create filament extruders that can make medical-quality ...
(Date:8/21/2014)... resulting in severe abdominal pain, vomiting and systemic inflammation. ... diagnosed with the disease resulting in 1000 deaths. There ... intravenous fluid and nutritional support. , Dr Jason ... the research, said "The major causes of pancreatitis include ... intake combined with a high fat diet. In fact, ...
(Date:8/20/2014)... Researchers at Huntsman Cancer Institute (HCI) at the University ... the gene that encodes BCR-ABL, the unregulated enzyme driving ... the American Cancer Society, nearly 6,000 new cases of ... in use, called tyrosine kinase inhibitors (TKIs), target BCR-ABL ... not cure CML but control it in a way ...
Breaking Biology News(10 mins):Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Insulin offers new hope for the treatment of acute pancreatitis 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... the Smithsonian Institution and the Hawaii Institute of Marine ... created the first frozen bank for Hawaiian corals in ... preserve their diversity in Hawaii. Mary Hagedorn, an adjunct ... the Smithsonian Conservation Biology Institute, leads the laboratory at ...
... underlay many cancers. Rui Martinho at the Instituto Gulbenkian ... in Ghent (Belgium) and Bergen (Norway) will use the ... identified in the test-tube, impact on the way cells ... the Association for International Cancer Research (AICR), will provide ...
... of an old antibiotic may help diabetics avoid a stroke ... researchers report. Minocycline, a drug already under study at ... blood vessels in the brain that increases their stroke risk ... Dr. Adviye Ergul, physiologist in the MCG Schools of Medicine ...
Cached Biology News:Smithsonian scientists help create first frozen repository for Hawaiian coral 2Understanding cancer using the fruit fly 2Antibiotic may reduce stroke risk and injury in diabetics 2
(Date:8/22/2014)... Texas (PRWEB) August 23, 2014 ... the current state of the Papain industry in ... overview of the industry, including definitions, applications and ... domestic market analysis are provided with a focus ... the market. A comparison between the international and ...
(Date:8/22/2014)... in the scientific journal PLoS One , ... effect of serotonin on sensitivity to pain using ... "Serotonin is a small molecule known to be ... from the control of sleep and appetite, to ... is also popularly thought to contribute to feelings ...
(Date:8/22/2014)... 2014 The Global and China Diabetes ... the current state of the Diabetes Drug industry in ... overview of the industry, including definitions, applications and industry ... analysis are provided with a focus on history, developments, ... between the international and Chinese situation is also offered. ...
(Date:8/22/2014)... Los Angeles (PRWEB) August 22, 2014 ... for age-defying products, is in the spotlight again. ... night cream and its NeriumFirmTM Body Contouring Cream ... presented by Backstage Creations during the 66th Primetime ... the patented NAE-8® extract, third-party clinical trials show ...
Breaking Biology Technology:Papain Industry Global & China Development Trend and Proposals Analysis Research Report Available at DeepResearchReports.com 2Papain Industry Global & China Development Trend and Proposals Analysis Research Report Available at DeepResearchReports.com 3From happiness to pain: Understanding serotonin's function 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 3Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3
... BioSciences, Inc. (OTC Bulletin Board: GNLK ... that it ranked number 33 on Technology Fast 500 ... growing technology, media, telecommunications, life sciences and clean technology ... the period 2006-2010. GeneLink,s chief executive ...
... Inc ., a late-stage epigenetics oncology company, announced today that members ... BIO Investor Forum , San Francisco, CA, October ... Target , Panel Discussion: HDACi and Their Progress in the Clinic, ... Healthcare Conference , New York, NY, November 16, 1:30 PM ET ...
... 24, 2011 Modern Plastics, one of the largest ... plastics, has become ISO 13485-2003 certified for the distribution ... Resin. "This is an extraordinary achievement ... service and quality," said Bing J. Carbone, President at ...
Cached Biology Technology:GeneLink BioSciences, Inc. Ranked Number 33 Fastest Growing Company in North America on Deloitte's 2011 Technology Fast 500™ 2GeneLink BioSciences, Inc. Ranked Number 33 Fastest Growing Company in North America on Deloitte's 2011 Technology Fast 500™ 3Syndax Pharmaceuticals to Present at Upcoming Fall Conferences 2
... Desselberger (1995) • This book is ... classical and molecular techniques currently used ... and analysis of virus-specific antibodies and ... presented covering immunoassays, blotting and hybridization ...
Bovine Serum...
Mus musculus junctophilin 2 (Jph2) Antigen: Recombinant Protein...
2.0 GHz Compaq Computer with 512 MB RAM, 32 MB AGP Graphics Card, 40 GB Hard Drive, 1 Serial Port & Open PCI Slot, Windows 2000 OS, MS Office, CD Read/Writer and 18 Flat Panel Monitor...
Biology Products: