Since ALS is a progressive, fatal disease characterized by the loss of motor neurons, motor neuron preservation is critical. According to the researchers, the combination treatment of BMT and GCSF had a greater impact via significant neuroprotective and neuroregenerative effects than when compared to BMT alone.
GCSF was administered to not only provide a neuroprotective effect, but also to stimulate the proliferation of bone marrow cells," said Dr. Abe.
Contact: Prof. Koji Abe, Department of Neurology,
Graduate School of M, dentistry and Pharmaceutical Sciences,
Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Tel: 81-86-235-7365 Fax: 81-86-235-7368 Email: firstname.lastname@example.org
Citation: Ohta, Y.; Nagai, M.; Miyazaki, K.; Tanaka, N.; Kawai, H.; Mimoto, T.; Morimoto, N.; Kurata, T.; Ikeda, Y.; Matsuura T.; Abe, K. Neuroprotective and Angiogenic Effects of Bone Marrow Transplantation Combined With Granulocyte Colony-Stimulating Factor in a Mouse Model of Amyotrophic Lateral Sclerosis. Cell Med. 2(2):69-83; 2011
|Contact: David Eve|
Cell Transplantation Center of Excellence for Aging and Brain Repair