Contact: Dr. Sung-Rae Cho, Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, Korea 120-752
Tel: +82 2 2228-3715 Fax: +82 2 363-2795 Email: firstname.lastname@example.org
Citation: Seo, J. H.; Jang, I. K.; Kim, H.; Yang, M. S.; Lee, J. E.; Kim, H. E.; Eom, Y-W.; Lee, D-H.; Yu, J. H.; Kim, J. Y.; Kim, H. O.; Cho, S-R. Early immunomodulation by intravenously transplanted mesenchymal stem cells promotes functional recovery in spinal cord injured rats. Cell Med. 2(2):55-67; 2011.
Bone marrow cell transplantation coupled with stimulating factor offers neuroprotective and angiogenic effects in ALS animal models
In this the first report showing the effects of bone marrow cell transplantation (BMT) combined with granulocyte colony-stimulating factor (GCSF) in mouse models of ALS, researchers from Okayama University, Japan demonstrated that the co-treatment potentially confers neuroprotective and angiogenic (blood vessel growth) effects on the test mice.
"Combined treatment with BMT and GCSF delayed disease progression and prolonged the survival of G93A mice while BMT or GCSF treatment alone did not," said corresponding author professor Koji Abe of the Department of Neurology in the Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences. "In addition, the mice treated with BMT and GCSF also showed a reduction in motor neuron loss, induced neuronal precursor cell proliferation, and th
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Cell Transplantation Center of Excellence for Aging and Brain Repair