Navigation Links
New studies show spinal cord injury and ALS respond to cell transplantation

Tampa, Fla. (July. 18 , 2012) Two studies published in a recent issue of Cell Medicine [2(2)] report on the therapeutic efficacy of stem cell transplantation in animal models of amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI). Cell Medicine is freely available on-line at

Mensenchymal stem cell transplantation in spinal cord injured rats promotes functional recovery

Transplantation of mesenchymal stem cells (MSCs), multipotent stem cells with the ability to differentiate into a variety of cell types with renewal capacities, has been found to enhance laboratory animal function after induced spinal cord injury. However, the biological mechanism of the functional enhancement has not been clearly defined.

In an attempt to gain a clearer picture of the mechanism, a team of Korean researchers transplanted MSCs derived from human umbilical cord blood into the tail veins of laboratory rats immediately after spinal cord injury. The intravenous route was selected because the researchers felt that injection into the damaged site could further traumatize the injured spinal cord, although intravenously injected MSCs risk being eliminated by the host immune system.

"We found that MSCs express immunomodulatory effects during the acute phase following SCI," said study corresponding author Dr. Sung-Rae Cho of the Yonsei University College of Medicine in Seoul, Korea. "In our study, MSCs suppressed activated micoglia and inflammatory cytokines, increased anti-inflammatory cytokines and, consequently, promoted functional recovery in SCI rats." They reported "modest but significant improvement" in a number of functional test scores in the rats subjected to transplantation when compared with control group animals not subjected to cell transplantation. The researchers suggested that their study not only confirmed the established link between microglial activation and inflammatory cytokines, but also demonstrated that functional recovery might be attributed to immunomodulatory effects rather than cell replacement. They also recommended that autologous (self-donated) MSCs, rather than human-derived MSCs, should be used in subsequent studies to "suppress undesirable immune response."

Contact: Dr. Sung-Rae Cho, Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, Korea 120-752
Tel: +82 2 2228-3715 Fax: +82 2 363-2795 Email:

Citation: Seo, J. H.; Jang, I. K.; Kim, H.; Yang, M. S.; Lee, J. E.; Kim, H. E.; Eom, Y-W.; Lee, D-H.; Yu, J. H.; Kim, J. Y.; Kim, H. O.; Cho, S-R. Early immunomodulation by intravenously transplanted mesenchymal stem cells promotes functional recovery in spinal cord injured rats. Cell Med. 2(2):55-67; 2011.

Bone marrow cell transplantation coupled with stimulating factor offers neuroprotective and angiogenic effects in ALS animal models

In this the first report showing the effects of bone marrow cell transplantation (BMT) combined with granulocyte colony-stimulating factor (GCSF) in mouse models of ALS, researchers from Okayama University, Japan demonstrated that the co-treatment potentially confers neuroprotective and angiogenic (blood vessel growth) effects on the test mice.

"Combined treatment with BMT and GCSF delayed disease progression and prolonged the survival of G93A mice while BMT or GCSF treatment alone did not," said corresponding author professor Koji Abe of the Department of Neurology in the Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences. "In addition, the mice treated with BMT and GCSF also showed a reduction in motor neuron loss, induced neuronal precursor cell proliferation, and the increased expression of several neurotrophic factors."

Since ALS is a progressive, fatal disease characterized by the loss of motor neurons, motor neuron preservation is critical. According to the researchers, the combination treatment of BMT and GCSF had a greater impact via significant neuroprotective and neuroregenerative effects than when compared to BMT alone.

GCSF was administered to not only provide a neuroprotective effect, but also to stimulate the proliferation of bone marrow cells," said Dr. Abe.

Contact: Prof. Koji Abe, Department of Neurology,
Graduate School of M, dentistry and Pharmaceutical Sciences,
Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Tel: 81-86-235-7365 Fax: 81-86-235-7368 Email:

Citation: Ohta, Y.; Nagai, M.; Miyazaki, K.; Tanaka, N.; Kawai, H.; Mimoto, T.; Morimoto, N.; Kurata, T.; Ikeda, Y.; Matsuura T.; Abe, K. Neuroprotective and Angiogenic Effects of Bone Marrow Transplantation Combined With Granulocyte Colony-Stimulating Factor in a Mouse Model of Amyotrophic Lateral Sclerosis. Cell Med. 2(2):69-83; 2011


Contact: David Eve
Cell Transplantation Center of Excellence for Aging and Brain Repair

Related biology news :

1. FirstMark Scientific Board of Advisors Meet to Discuss New Clinical Studies for PREvent
2. Preclinical studies use specialized ultrasound to detect presence of cancer
3. GSA Bulletin presents studies in Antarctica, Italy, Mexico, Algeria, Mongolia, and more
4. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
5. Miniature Sandia sensors may advance climate studies
6. Improving equine health: Research studies vaccinations to protect newborn foals
7. Autism Speaks awards $1.1 million to fund high priority studies
8. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
9. Studies reveal structure of EV71, a virus causing childhood illnesses
10. Neuroprotective dietary supplements for chronic spinal cord injury
11. Neural stem cell transplants for spinal cord injury maximized by combined, complimentary therapies
Post Your Comments:
(Date:9/30/2015)... , Sept. 30, 2015  The U.S. Court ... issued another key ruling in favor of Crossmatch ... Korean fingerprint scanner company Suprema and its U.S. partner ... 1930, a trade provision that declares it unlawful to ... by infringing two of Crossmatch,s patents, the 5,900,993 patent ...
(Date:9/28/2015)... YORK , Sept. 28, 2015 /PRNewswire/ ... announced today that its expedited traveler service ... innovative platform transforms travel, bringing a frictionless ... its members. "CLEAR offers our ... enhances customer service," said Jim Smith ...
(Date:9/28/2015)... , Sept. 28, 2015 Synaptics Inc. (NASDAQ: ... solutions, today announced that Lenovo has selected Synaptics , ... FS4202, for its latest smartphone, the Vibe P1. The ... to unlock the device and provide swift access to ... The feature-rich Natural ID FS4202 sensor solution utilizes AES256-bit ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... JACKSONVILLE, Florida , October 13, 2015 ... company specializing in the development of innovative peptide and ... & metastatic disease, will be a featured presenting company ... at the Wyndham Grand Hotel in ... --> TapImmune, Inc. (TPIV), a clinical-stage immunotherapy ...
(Date:10/13/2015)... ... October 13, 2015 , ... Clinovo recently appointed Jeff Parr ... company’s fast growing clinical data solutions business. , Jeff Parr has spent the past ... sizes, including Avery Dennison, Thermo Fisher, and Ab Sciex to name a few. ...
(Date:10/13/2015)... the United States , Canada ... of all new cases of kidney cancer.   --> ... and Europe .  PRCC represents about 14% of ... China MediTech Limited ("Chi-Med") (AIM: HCM) today announces that Hutchison MediPharma ... have completed enrolment in a global Phase II study of savolitinib ...
(Date:10/12/2015)... , Oct. 12, 2015 This report ... which include cell type, products, applications, end-user markets and ... REPORT HIGHLIGHTS The global cell expansion market generated ... expected to reach revenues of $9.7 billion in 2015 ... growth rate (CAGR) of 17.8% from 2015 to 2020. ...
Breaking Biology Technology: