Navigation Links
New studies reveal downstream processes of ion channel inactivation
Date:3/2/2010

Two studies by researchers at The Johns Hopkins University School of Medicine reveal new details of the mechanisms of ion channel inactivation. The papers appear in the March issue of The Journal of General Physiology (www.jgp.org).

After opening, many ion channels spontaneously close by inactivation, a process distinct from that involved in opening. The inactivation of channels is important for a variety of biological processes, including the timing of action potentials and the control of calcium permeability, which affects many aspects of intracellular signaling. Although the events of Ca2+-dependent inactivation (CDI) and voltage-dependent inactivation (VDI) have been unveiled in the past decade, the downstream mechanisms remained unclear.

Tadross et al. studied both CDI and VDI in Cav1.3 channels and showed them to differ not only in their initiation mechanisms but also in their distinct molecular endpoints. For CDI, a clear pattern emerges: activation-enhancing mutations proportionately weaken inactivation, supporting the idea that CDI reduces channel permeability by allosteric hindrance of the activation gate. For VDI, the data implicate a "hinged lidshield" mechanism, similar to a hinged-lid process, with a previously unrecognized feature, a "shield" in Cav1.3 channels that is specialized to repel lid closure.

In a Commentary accompanying the papers, Jianmin Cui (Washington University, St. Louis) examines the mechanisms of inactivation and provides context for the importance of the new findings by Tadross et al.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Claims of sex-related differences in genetic association studies often not properly validated
2. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
3. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
4. Studies: Children obese due to a host of unhealthy pressures
5. Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
6. LSU professor studies army-ant-following birds
7. 2 carotid artery stenting studies show results comparable to AHA guidelines
8. NIH grants enable energy studies
9. New studies on schizophrenia, depression, trauma and autism highlight annual meeting
10. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
11. New studies suggest brain overgrowth in 1-year-olds linked to development of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... 2014: Globally, cardiovascular disease (CVD) claims 17 million lives ... an additional 9.4 million. 1 New research presented ... Congress in Montpellier, France on September 15, 2014, suggests ... role. , At the Milk and Dairy ... milk and risk for hypertension and CVD was examined ...
(Date:9/15/2014)... available in German . ... the fossil energy carrier natural gas offers a variety ... Nevertheless, a consequent market penetration is still pending because ... Scientists of the Helmholtz Centre for Environ-mental Research (UFZ) ... Members of the IEA Task 37 (Energy from Biogas) ...
(Date:9/12/2014)... , Sept. 12, 2014 Research and ... "Global IC Card Management System Industry Report 2014" ... IC Card Management System Industry Report 2014 is a ... the global IC card management system. The ... definitions, classifications, applications and industry chain structure. The IC ...
Breaking Biology News(10 mins):Dairy consumption linked to lower blood pressure and cardiovascular disease risk 2The biomethane market needs clear frame conditions for further growth 2The biomethane market needs clear frame conditions for further growth 3Global IC Card Management System Industry Report 2014 2
... LSU,s Sibel Bargu, along with her former graduate student Ana ... LSU,s School of the Coast & Environment, has discovered toxic ... the first time. The recent findings were published in the ... journals, the Proceedings of the National Academy of Sciences ...
... dioxide injected deep underground to help fight climate change could ... up levels of contaminants in the water tenfold or more ... scientists. Based on a year-long analysis of core samples ... contamination is real, but there are ways to avoid or ...
... 9, 2010 For Immediate Release Scientists from ... identified for the first time a novel mechanism that ... body,s natural 24-hour physiological cycle. These new findings could ... shift work, and sleep disturbances, but also for disorders ...
Cached Biology News:LSU oceanography researcher discovers toxic algae in open water 2LSU oceanography researcher discovers toxic algae in open water 3Leaking underground CO2 storage could contaminate drinking water 2Scripps Research scientists identify new mechanism regulating daily biological rhythms 2Scripps Research scientists identify new mechanism regulating daily biological rhythms 3
(Date:9/15/2014)... Paula, CA (PRWEB) September 15, 2014 ... long term implantable silicones for the medical device ... responsive silicone gel for the implantable medical device ... a unique crosslink technology delivering a silicone gel ... The Dual Matrix technology consists of two ...
(Date:9/15/2014)... Rome, GA (PRWEB) September 15, 2014 ... ( http://www.hydrodynamics.com ) announced today that it will ... Verdes Estates, CA ( http://www.proteaf.com ) for implementing ... in high value continuous processing. Continuous flow ... in the chemical, pharmaceutical and petrochemical markets for ...
(Date:9/12/2014)... a magnet using an electric field (magnetoelectric memory ... the next-generation technology for information processing and storage. ... effect, due to the coexistence of electric and ... of spontaneous electric and magnetic polarizations is rare ... of the MEM effect. This article briefly reviews ...
(Date:9/12/2014)... , September 12, 2014 On Thursday, ... 0.12%, the Dow Jones Industrial Average finished the day 0.12% ... up 0.09%. The gains were broad based as seven out ... 500 Health Care Sector Index ended the day at 741.83, ... last one month. Investor-Edge has initiated coverage on the following ...
Breaking Biology Technology:Applied Silicone Launches Silicone Gel System with Dual Matrix Technology 2Hydro Dynamics Partners with the Continuous Flow Chemistry Experts of Proteaf Technologies 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 3Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 4Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 5
... , , , For purification of up to 10 mg ultrapure plasmid , ... for efficient , purification of plasmid DNA , , ... benefits , , ... by 2x CsCl-gradient centrifugation , , ...
... , , , , , ... Svegliati, Michele Luchetti, and Armando Gabrielli , Laboratorio ... Scientifico, Ancona, Italy , , ... GC-rich sequences difficult to amplify by PCR. This article ...
... , , , QIAGEN introduces the ... automated, high-throughput DNA purification , from high-copy plasmids. ... for a lysate clearing step. Plasmid DNA purification is performed using ... procedure. The protocol , is faster and easier ...
Cached Biology Technology:Successful PCR amplification and subcloning of a GC-rich DNA fragment 2Successful PCR amplification and subcloning of a GC-rich DNA fragment 3Successful PCR amplification and subcloning of a GC-rich DNA fragment 4Successful PCR amplification and subcloning of a GC-rich DNA fragment 5DirectPrep 96 Miniprep System for cost-effective, high-throughput plasmid , DNA purification 2DirectPrep 96 Miniprep System for cost-effective, high-throughput plasmid , DNA purification 3DirectPrep 96 Miniprep System for cost-effective, high-throughput plasmid , DNA purification 4
...
Request Info...
... vectors carry the kanamycin resistance gene that ... Spontaneous generation of multiple insertion events can ... of Geneticin Reagent. Pichia transformants are selected ... level of resistance to Geneticin Reagent. The ...
... Synthetic peptide derived from the C-terminal ... Math-2. Specificity: Specific for the ... (positive controls: human U251 A172 IMR-32 ... rat brain homogenates)Storage: Store at -20C ...
Biology Products: