Navigation Links
New stroke therapy successful in rats
Date:1/12/2010

Irvine, Calif., Jan. 12, 2010 People with impaired mobility after a stroke soon may have a therapy that restores limb function long after the injury, if a supplemental protein works as well in humans as it does in paralyzed rats.

Two new studies by UC Irvine biologists have found that a protein naturally occurring in humans restores motor function in rats after a stroke. Administered directly to the brain, the protein restores 99 percent of lost movement; if it's given through the nose, 70 percent of lost movement is regained. Untreated rats improve by only 30 percent.

"No drugs exist that will help a stroke after a few days. If you have a stroke, you don't have many treatment options," said James Fallon, psychiatry & human behavior professor and senior co-author of the studies. "Now we have evidence there may be therapies that can repair damage to a significant degree long after the stroke. It's a completely unexpected and remarkable finding, and it's worth trying in humans."

The studies, carried out by UCI postdoctoral researcher Magda Guerra-Crespo, chronicle the success of a small protein called transforming growth factor alpha, which plays critical tissue-forming and developmental roles in humans from just after conception through birth and into old age.

"TGF alpha has been studied for two decades in other organ systems but never before has been shown to reverse the symptoms of a stroke," Guerra-Crespo said. No lasting side effects were observed.

In the first study, published in the journal Neuroscience, scientists sought to learn whether TGF alpha administered directly to the brain could help rats with stroke-induced loss of limb function, typically on one side as is seen in humans.

When put inside a cylinder, healthy rats will jump up with both front legs, but stroke-impaired rats will use just one leg, favoring the injured side. When given a choice of directions to walk, impaired rats will move tow
'/>"/>

Contact: Jennifer Fitzenberger
jfitzen@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study reveals how one form of natural vitamin E protects brain after stroke
2. Observation about how nervous system learns and encodes motion could improve stroke recovery
3. New understanding about mechanism for cell death after stroke leads to possible therapy
4. Top interventional radiologists, neurointerventionists explore stroke care through CLOTS
5. Beta-blockers and stroke -- new insights into their use for older people
6. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
7. Single gene defect can cause stroke, other artery diseases
8. Stem cells replace stroke-damaged tissue in rats
9. Penn research team tests bedside monitoring of brain blood flow and metabolism in stroke victims
10. Predicting risk of stroke from ones genetic blueprint
11. Researchers identify a cell type that limits stroke damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Profile Solutions, Inc. (OTC: PSIQ), a leading ... pleased to announce that Dr Gerry Bedore ... of its scientific advisory board. ... leader in technology-enhanced learning models. He was a co-founder ... studies and books focused on online student success and ...
(Date:4/17/2015)... April 17, 2015 ... and technological advancement to drive biometric systems market ... 2020   According to a recently ... Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... register growth at CAGR of over 22% through ...
(Date:4/13/2015)... April 13, 2015  higi, a leading cloud-based consumer ... more fully engage with their communities around health and ... protected and secure API.  ... most accessible, affordable, and convenient vehicle to receive validated ... The API will allow higi,s trusted ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... conducted at Georgia State University suggest that a "fight" between ... kicked off by another type of bacteria, may be linked ... that the "fight" continues after the instigator bacteria have been ... biology at the GSU Center for Inflammation, Immunity and Infection. ...
... first time a surprising and unexpected plasticity in the ... made in early development. Scientists found that ... gene that controls cell fate by regulating other genes, ... progenitor cells in blood forming tissues to become something ...
... bones from what is known as osteoporosis, which may lead ... of the bones results from an imbalance between the normal ... laying down of new bone, an ongoing process for both ... poorly understood reasons, after menopause the resorption of old bone ...
Cached Biology News:Embryonic blood vessels that make blood stem cells can also make beating heart muscles 2Embryonic blood vessels that make blood stem cells can also make beating heart muscles 3Mechanisms for a beneficial effect of moderate alcohol consumption on osteoporosis in women 2
(Date:4/27/2015)... 2015 Dr. Robert Hanzlik, whose groundbreaking ... carries implications for advancing the creation of safer pharmaceuticals, ... National University , the second-largest private, nonprofit university in ... a professor at the University of Kansas School of ... starts at 5 p.m. and takes place at National ...
(Date:4/27/2015)... NORTH BRUNSWICK, New Jersey , ... Pharmaceuticals, société de découverte médicamenteuse spécialisée ... d,agents antibiotiques destinés à soigner les ... annoncé aujourd,hui la présentation de données ... clinique majeur, le TXA709, dans la ...
(Date:4/27/2015)... April 27, 2015 SynGen Inc., a company ... systems that harvest stem and progenitor cells from umbilical ... announced today that it has added three new members ... Cord Blood Business Units focus on product commercialization. ... as its Vice President and Chief Financial Officer.  Chuck ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 DryLet, ... use in applications such as animal waste reduction, ... oil reduction in wastewater treatment plants and restaurant ... exhibitor at the Texas Commission on Environmental Quality ... in Austin, Texas. , The company will highlight ...
Breaking Biology Technology:Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 3TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 2TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 3TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 4TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 5TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 6SynGen Inc. Expands Its Management Team 2DryLet to Showcase Multiple Products at Texas Commission on Environmental Quality Trade Fair and Conference May 5-6 in Austin, Texas 2
... France, January 10 Essilor,of America, Essilor International,s ... the United States with the acquisition,of Interstate Optical ... Interstate,s two laboratories in Mansfield, Ohio and,Indianapolis, Indiana ... has full-year sales of US$26 million and 210 ...
... Sobol Shapiro LLP,( http://www.hbsslaw.com/cellcyte.htm ) today announced ... (OTC Bulletin Board: CCYG) for potential,violations of ... CellCyte,s shares plunged 55 percent,after news reports ... educational and professional credentials., CellCyte,s stock ...
... Jan. 9 Omeros Corporation announced today that,it has ... relating to the proposed initial public offering of shares ... to be sold in the offering,will be offered by ... sole book-running manager. Pacific Growth Equities, LLC will be ...
Cached Biology Technology:Hagens Berman Sobol Shapiro Investigating CellCyte 2Omeros Corporation Files Registration Statement for Proposed Initial Public Offering 2
ID clarifier: platform...
The sealed ice cooling unit is used to absorb heat that is generated during transfers performed in the Criterion blotter....
... The four-bay DNA Engine Tetrad ... of interchangeable Alpha units (sample-holder, heat-pump ... numbers of vessels. A Pentium-class computer ... displays current block, sample, and lid ...
The SVT3-2 diverter valve is a 3-port, 2-position valve for use with the BioLogic DuoFlow system....
Biology Products: