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New strategy to combat cystitis
Date:6/3/2011

ute of Structural and Molecular Biology, University of London, is investigating the mechanism responsible for the biosynthesis of these pili. For this purpose, they are using X-ray diffraction - the standard technique for determining the structure of proteins. Detailed knowledge about the structure of proteins is necessary to gain an insight into how they function.

Han Remaut and colleagues were the first to successfully image the assembly complex leading to pili biosynthesis. Furthermore, this is also the first snapshot of a protein transporter in action.

New antibiotics for the treatment of infections of the urinary tract

This detailed knowledge about the biosynthesis of type 1 pili from E. coli can form the basis for the development of medicines which block the formation of the pili. If bacteria can no longer cling to the epithelial cells of the bladder, they will no longer be able to cause an infection. The mechanism responsible for E.coli attaching to the bladder is also used by other bacteria. As a result, this research can also contribute to the fight against other infectious diseases such as food poisoning or traveler's diarrhea.


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Contact: Joris Gansemans
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

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