Navigation Links
New strategy for stimulating neurogenesis may lead to drugs to improve cognition and mood
Date:4/3/2011

other strategies, may also be useful in treating some of the learning deficits seen in people with normal or pathological aging, such as Alzheimer's disease. In fact, there is already evidence that pattern separation declines during normal aging.

"This paper, as a consequence, may stimulate a whole area of research in humans to try to determine who in the population may have a pattern separation deficit, and whether it is restricted to the emotional domain, or is present even while performing tasks devoid of emotional salience. Once these studies are done in humans, it may be possible to treat these people with specifically targeted drugs or more personalized therapies," said Dr. Hen.

The researchers say that the genetic strategy used to stimulate neurogenesis in their experiments can be mimicked pharmacologically, potentially leading to the development of new drugs to reverse pattern separation deficits. One such class of drugs the investigators are currently testing BAX inhibitors works by blocking cell death.

"These drugs are basically doing the same thing that we did with our genetic manipulationnamely, increasing the survival of the young neurons which normally undergo a process of cell death that eliminates at least half of these neurons. Now instead of dying, the neurons will go on to survive," said Dr. Sahay.

Some BAX inhibitors have been developed for stroke research, where the goal has also been to prevent neurons from dying. The Columbia researchers plan to begin testing the BAX inhibitors in mice shortly. And if they produce cognitive benefits, the testing will be extended to clinical trials to determine if there's also a beneficial effect in humans.

"I think we're getting closer to harnessing neurogenesis to improve cognition and mood in humans. This research may also help explain a bit of a mystery in the field, which we still don't understand, regarding how the hippocampus can be involved with both cogni
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Economics and evolution help scientists identify new strategy to control antibiotic resistance
2. Study shows new treatment strategy effective for certain lung cancers
3. H1N1 pandemic points to vaccine strategy for multiple flu strains
4. Canadian marine biodiversity scientists forging strategy for sustainable ocean use
5. New insect birth control strategy zaps cotton pests
6. Frost & Sullivan Honours Fingerprint Cards AB with Product Line Strategy Award
7. A strategy to fix a broken heart
8. UM School of Medicine scientists develop new strategy that may improve cognition
9. Molecular discovery suggests new strategy to fight cancer drug resistance
10. Scientists call for a new strategy for polar ocean observation
11. Flus evolution strategy strikes perfect balance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... 2014Many Americans across racial and ethnic groups describe ... on their day-to-day life, more so than other ... speech (57% of African-Americans, 49% of non-Hispanic whites, ... asked which disease or ailment is the worst ... among African-Americans followed by AIDS/HIV. Hispanics and ...
(Date:9/18/2014)... from several disciplines will be celebrated tonight at the ... in improving the health of premature infants and in ... The researchers, whose work was supported by the National ... former Atomic Energy Commission, will be honored at a ... A bipartisan group of Members of Congress will be ...
(Date:9/18/2014)... comprise all spheres of our planet. Manifold interactions ... and perturbations that resulted in increases of the ... climate changes which influence the complex biogeochemical processes ... these feedback mechanisms has become an important new ... past three decades. , In parallel, a novel ...
Breaking Biology News(10 mins):Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 33rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Greenhouse gas research enters a new era 2
... majority of orchids are found in habitats where light ... is not surprising that many achlorophyllous (lacking chlorophyll), as ... symbionts to supply them with carbohydrates in order to ... of habitats and range in their photosynthetic capabilities. ...
... Research to be presented at the upcoming annual meeting of ... foremost society for research into all aspects of eating and ... increases our willingness to pay for food, while simultaneously decreasing ... ever wondered about why you are willing to pay more ...
... instructions for developing limbs and digits were present in ... crawled on to land, researchers have discovered. Genetic ... When a particular switch taken from fish DNA is ... in the developing limb region of embryos, University of ...
Cached Biology News:Orchids and fungi: An unexpected case of symbiosis 2Orchids and fungi: An unexpected case of symbiosis 3Orchids and fungi: An unexpected case of symbiosis 4Genetic switch for limbs and digits found in ancient fish 2Genetic switch for limbs and digits found in ancient fish 3
(Date:9/20/2014)... September 20, 2014 MediVet America ... perform a groundbreaking surgery at the specialized Wolvega Horse ... superficial digital flexor tendon was ruptured 90% and her ... injury is a death sentence for a horse. , ... stem cell treatments . This revolutionary regenerative option ...
(Date:9/19/2014)... 2014 Follow us on ... revolutionize the world has attracted diverse players including ... start-ups. The early years of nanotechnology development was ... to the high risks involved, which deterred private ... this evolving technology have been growing over the ...
(Date:9/19/2014)... SPRINGS, Florida , September 19, 2014 ... companies release latest developments, patents and results of studies ... GNSZ), Eli Lilly and Company (NYSE: LLY ... Celgene Corporation (NASDAQ: CELG ) and Arena ... GNSZ), a leader in developing prodrug therapeutics for the ...
(Date:9/19/2014)... -- The new , Healthcare and Life Sciences ... on PharmaBoardroom.com for free download , looks ... Spanish economy in 2009, and the austerity measures that followed, ... in times of trouble. "Despite the crisis, ... market, and the general conditions to invest are favorable to ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3
... ROCHESTER, N.Y., July 14 Bio-Optronics, Inc., a leader ... an intelligent, hosted software solution that can simultaneously handle the ... build the best staff schedules. , , ... process. , , Bio-Optronics ...
... VIENNA, Austria, July 14 Elan Corporation, plc (NYSE: ... presented information this week at the Alzheimer Association 2009 International Conference ... presentation about the growing burden of care and costs associated with ... sheds light on the impact of AD, which, as the population ...
... Kelly ... topic of "Capitalizing on Trends in Negotiation, Contracts, and Risk and Reward." Discussion ... providers such as clinical research organizations. , ... Washington, DC (PRWEB) July 14, 2009 -- ClearTrial ( www.cleartrial.com ...
Cached Biology Technology:NEW Momentum(TM) Physician and Staff Scheduling Software for Imaging Centers, OB/GYN, and Other Specialty Practices Improves Productivity and Equity in Scheduling 2Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 2Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 3Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 4Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 5Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 6Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 7ClearTrial Selected to Lead Executive Panel from Pharmaceutical and Service Provider Companies at ExL Conference 2ClearTrial Selected to Lead Executive Panel from Pharmaceutical and Service Provider Companies at ExL Conference 3
... DX's sensitivity of DNA detection has been improved. ... an agarose gel can be detected > 20 ... be purified by organic solvent extraction or with ... worked well.) DNA excised from agarose gel ...
... The RapidTrace SPE Workstation is a ... phase extraction platform. Utilizing 1ml or 3ml ... process up to 100 samples in less ... be loaded with 10 cartridges, and up ...
... form of cell suicide, which follows a ... of this process is a cascade of ... participate in a series of reactions that ... and result in the cleavage of protein ...
... manufactured for DNA purification from agarose gels ... light. The Purification of DNA from an ... work. The conventional method of visualizing DNA ... light damages DNA and significantly decreases cloning ...
Biology Products: