Pattern separation is not only important for learning; it may also be important for anxiety disorders, including post traumatic stress disorder (PTSD) and panic disorder. People with PTSD, say the researchers, have a more generalized fear response, so that when they are placed in a situation that reminds them of even one aspect of their trauma, they frequently have a full fear response.
"I think a good example of this is someone who has developed PTSD as a result of 9/11. For them, the simple sight of an airplane or high tower may be enough to reawaken the initial traumatic episode and bring back the full aversive memory. Sometimes these generalizations become so pervasive that people basically don't want to leave their home anymore because everything reminds them of the original event," said Dr. Hen.
The normal adaptive response, say the authors of the study, is to separate similar events or experiences. "Even though I may remember 9/11, when I see an airplane over NYC, I am able to recognize that it's a different situation and process it accordingly, while someone in the same situation with PTSD may re-experience the traumatic memory of 9/11 and have a panic attack. So this may be one reason why stimulating neurogenesis to improve pattern separation may contribute to treatment of some of these anxiety disorders," said Dr. Hen.
Enhancing pattern separation, by either the method the Columbia researchers used, or
|Contact: Karin Eskenazi|
Columbia University Medical Center